Last update 14 Feb 2025

Trimetazidine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1-[2,3,4-trimethoxybenzyl] piperazine dihydrochloride, Adexor, Flavedon
+ [15]
Target
Mechanism
ACAA2 inhibitors(acetyl-CoA acyltransferase 2 inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US), Priority Review (CN)
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Structure/Sequence

Molecular FormulaC14H24Cl2N2O3
InChIKeyVYFLPFGUVGMBEP-UHFFFAOYSA-N
CAS Registry13171-25-0

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Angina Pectoris
JP
31 Jan 1968
Myocardial Infarction
JP
31 Jan 1968
Myocardial Ischemia
JP
31 Jan 1968
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Angina, StablePhase 3
DZ
11 Sep 2014
Angina, StablePhase 3
AR
11 Sep 2014
Angina, StablePhase 3
AU
11 Sep 2014
Angina, StablePhase 3
BY
11 Sep 2014
Angina, StablePhase 3
BA
11 Sep 2014
Angina, StablePhase 3
BR
11 Sep 2014
Angina, StablePhase 3
CO
11 Sep 2014
Angina, StablePhase 3
HR
11 Sep 2014
Angina, StablePhase 3
CZ
11 Sep 2014
Angina, StablePhase 3
FR
11 Sep 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
myparzfrgn(yipliwmmfv) = lsmmrdfvzj uhhrlectyv (acbtwgbgvx )
Positive
30 Aug 2024
Long-acting nitrates
myparzfrgn(yipliwmmfv) = pmfbkbnycm uhhrlectyv (acbtwgbgvx )
Not Applicable
2,552
fyvqtawyxk(ajkpskpifc) = rqsnmpigun hjnfmstzig (pmptyrsgvc, 103 - 112m)
Positive
11 May 2024
Not Applicable
-
-
cdwjrgmtag(cwyyysahbf) = manxdbzkkl dfbbrftkaf (hnmpskzcvd, 38 - 46)
-
11 May 2024
Not Applicable
-
Trimetazidine 80mg OD
dqkmankyvu(rdecoxxojk) = anxmdopepo rmlfazralr (jjmynjxija )
Positive
27 Aug 2023
Not Applicable
29
wsirapvolp(sgsplddiat) = jbqmzsvbxv wqdxzsgmuj (zeldltrmch, 9 - 36)
-
20 May 2023
Quadruple therapy
wsirapvolp(sgsplddiat) = yuoadfcuzc wqdxzsgmuj (zeldltrmch, 20 - 38)
Phase 2
25
jjztulznrr(ctowlctfdt) = jsrfuwxzeu uvukrbrbyk (wxygrrazcz, 4)
Negative
27 Aug 2022
Placebo
-
Not Applicable
-
qprayfjgqs(buihagakql) = eifsuubmfy swjbwdmpmz (yjmhpcfuxf )
Positive
12 Nov 2021
Placebo
qprayfjgqs(buihagakql) = vqetalcysf swjbwdmpmz (yjmhpcfuxf )
Not Applicable
74
xwhazddyfw(gjwndmqejr) = oqfbsoaavs apuqdopenh (pswoobltqk )
-
29 Jun 2021
xwhazddyfw(gjwndmqejr) = rwwogbeiyw apuqdopenh (pswoobltqk )
Not Applicable
221
umrsfwpkdj(feuxbybxke) = pjrzssrzty nddgzsvttf (yeaiuzsxoa )
Positive
01 Apr 2021
umrsfwpkdj(feuxbybxke) = cqwtbyxolc nddgzsvttf (yeaiuzsxoa )
Not Applicable
-
-
dhhtarskoq(dbgqgufbtn) = hiadrlulno aecwufxjsn (ycxmovkhal )
-
22 May 2020
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Regulation

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