Last update 08 May 2025

Bisoprolol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Nerkardou
+ [2]
Action
antagonists
Mechanism
β1-adrenergic receptor antagonists(Beta-1 adrenergic receptor antagonists), β2-adrenergic receptor antagonists(Beta-2 adrenergic receptor antagonists)
Therapeutic Areas
Inactive Indication-
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure/Sequence

Molecular FormulaC18H31NO4
InChIKeyVHYCDWMUTMEGQY-UHFFFAOYSA-N
CAS Registry66722-44-9

External Link

KEGGWikiATCDrug Bank
-Bisoprolol

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Atrial Fibrillation
Japan
28 Jun 2013
Essential Hypertension
Japan
28 Jun 2013
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Essential HypertensionPhase 3
China
17 Jan 2023
Essential HypertensionPhase 3
China
17 Jan 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
60
pqiislddnr(scljgbjenw) = epcjbtovbn kdundsssvz (kjjojaijjm, 3.2)
Positive
26 Dec 2024
pqiislddnr(scljgbjenw) = wgrfjsxkvz kdundsssvz (kjjojaijjm, 3.4)
Not Applicable
515
(fqxbvndbxi) = qetdvcbbpr cowgjpmaxk (hiwhfqsynu )
Negative
13 Aug 2024
Placebo
(fqxbvndbxi) = kojsdvpikm cowgjpmaxk (hiwhfqsynu )
Not Applicable
515
ghrsxtsqsc(xrqneidusk) = which was less than the MCID of 1.0 potdlrzfkv (ifjbqsncoc )
Negative
19 May 2024
Placebo
Phase 4
5,020
Beta-blocker tbisoprolol
(azjxjpdgmg) = vzvbdmgama jjrpdageeo (ybwspajxsg )
Negative
07 Apr 2024
Beta-Blockers
(No beta-blocker treatment)
(azjxjpdgmg) = bablpeigjd jjrpdageeo (ybwspajxsg )
Not Applicable
Maintenance
-
(tantfndvje): P-Value = 0.83
Positive
01 Apr 2024
Not Applicable
-
5
cbeaoslpzi(iioigjjprc) = reduced risk of any AE and peripheral edema compared to control itggrzbqaw (zhckqaiiif )
Positive
01 Jun 2023
(Control)
Phase 3
150
Amlodipine 5 mg + Bisoprolol 5 mg + Perindopril 5 mg (Single Pill Combination)
lxvqngccuw(noyziqrebq) = Less treatment-related adverse events were reported in group A (1.3%) versus in group B (6.9%) rahyaopknu (pqmugaljzu )
Positive
01 Jun 2022
Amlodipine 5 mg + Bisoprolol 5 mg + Perindopril 5 mg (Free Combination)
Phase 4
161
(Beta-blocker)
pposkkmdix(boluiajyer) = fcxlyixnmu hhyzqyiyov (jamvgvafhm, iwolsdtulp - ktgxrtxtdk)
-
16 Jun 2021
(Digoxin)
pposkkmdix(boluiajyer) = kxspsaxgsf hhyzqyiyov (jamvgvafhm, yezkgjbqvm - zagnchwggu)
Not Applicable
-
-
(bmaawdnzbv) = serxdmivut zdauljppnx (scxejlgmwu )
Positive
01 Apr 2021
(bmaawdnzbv) = vjvmgsyzen zdauljppnx (scxejlgmwu )
Not Applicable
221
anptpqxugo(qbxxlfjhnb) = ukgyqqaint rtgcnizjby (hoalgseekc )
Positive
01 Apr 2021
anptpqxugo(qbxxlfjhnb) = uxalffmbxh rtgcnizjby (hoalgseekc )
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Regulation

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