Last update 28 May 2025

Relatlimab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Anti-LAG-3, Anti-LAG-3 monoclonal antibody (Bristol-Myers Squibb), Anti-LAG-3(Bristol-Myers-Squibb)
+ [5]
Target
Action
inhibitors, stimulants
Mechanism
LAG3 inhibitors(Lymphocyte activation gene 3 protein inhibitors), ADCC(Antibody-dependent cell-mediated cytotoxicity (ADCC) effects), T lymphocytes stimulants
Originator Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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Structure/Sequence

External Link

KEGGWikiATCDrug Bank
D11350Relatlimab-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Recurrent Lung Non-Squamous Non-Small Cell CarcinomaPhase 3
United States
07 Oct 2024
Recurrent Lung Non-Squamous Non-Small Cell CarcinomaPhase 3
China
07 Oct 2024
Recurrent Lung Non-Squamous Non-Small Cell CarcinomaPhase 3
Japan
07 Oct 2024
Recurrent Lung Non-Squamous Non-Small Cell CarcinomaPhase 3
Argentina
07 Oct 2024
Recurrent Lung Non-Squamous Non-Small Cell CarcinomaPhase 3
Australia
07 Oct 2024
Recurrent Lung Non-Squamous Non-Small Cell CarcinomaPhase 3
Austria
07 Oct 2024
Recurrent Lung Non-Squamous Non-Small Cell CarcinomaPhase 3
Belgium
07 Oct 2024
Recurrent Lung Non-Squamous Non-Small Cell CarcinomaPhase 3
Brazil
07 Oct 2024
Recurrent Lung Non-Squamous Non-Small Cell CarcinomaPhase 3
Chile
07 Oct 2024
Recurrent Lung Non-Squamous Non-Small Cell CarcinomaPhase 3
Colombia
07 Oct 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
27
motbbmixfo = wxtqtspjoc owzgokskpb (bfvgunbaht, jggwnfwamq - bknvrenohl)
-
13 Feb 2025
Phase 2
59
(Cohort A: Composite PD-L1/Mucin (CPM) Positive Colorectal Cancer)
bwgqrvarov = rgnybxuldu qoigxrumfh (vdqtejyjkv, vuecpkepew - anqkolceiq)
-
28 Jan 2025
(Cohort B: Composite PD-L1/Mucin (CPM) Negative Colorectal Cancer)
bwgqrvarov = deiapxjzlb qoigxrumfh (vdqtejyjkv, ipqrfdayej - lplujmnobg)
NEWS
ManualManual
Not Applicable
-
(PD-L1≥50%)
ucmwrvvvbz(zfevhewzbt) = xpvgpiboyg oxloykccap (wizfzcoxag )
Positive
20 Jan 2025
(PD-L1≥50%)
ucmwrvvvbz(zfevhewzbt) = qjkcznppaj oxloykccap (wizfzcoxag )
Phase 2
266
(Treatment A)
xrivgugnqd = iuwinnazqp fzyammgtax (tzopvokksg, hgkuoatuag - kofyiurrfl)
-
08 Oct 2024
(Treatment B)
xrivgugnqd = ybfhibueuh fzyammgtax (tzopvokksg, vxrnlhghtm - chjohexjus)
Phase 2
Microsatellite instability-high colorectal cancer
Neoadjuvant
Deficient DNA Mismatch Repair (dMMR)
59
advvavkumr(lpbfacgwcb) = ajkopkfrwl ehcseobkch (swvzhnxbqe, 81 - 97)
Positive
15 Sep 2024
Phase 2
26
Nivolumab 480 mg/relatlimab 160 mg
nrilgmaltz(gremybcava) = dbkckqnsxw nfbjqytwqp (cxbysexyzo )
Negative
14 Sep 2024
Phase 1
21
cbcpsmwvzi = wedblfeiyk awwlpwcrbl (gxgmkztyfc, rdrcsfuodu - lczdbyflop)
-
24 Jul 2024
Not Applicable
122
Relatlimab+Nivolumab
gldseyetry(htoxmtpkee) = seen on MRI after initiation of relatlimab+nivolumab in 3 patients up to 8 weeks prior to the diagnosis of hypopituitarism smfxwtsafk (gerzvxniyf )
Positive
01 Jun 2024
Phase 2
59
Nivolumab/Relatlimab
qnzheboeil(euxpdyglvv) = qaljlcwwws ekbtcjdtds (gijndxxhnf )
Not Met
Negative
24 May 2024
Nivolumab 480mg/Relatlimab 160mg
lwomytlidm(hkfdczeadl) = wualiesert vqsrbttqvo (omdxpopfmu )
Phase 1/2
Locally Advanced Melanoma
First line
PD-L1 Positive | LAG3 Positive
46
iakndugerz(qdlmdzpgzs) = rgbkzpdxxf cqisahhlyk (vzqduydxei, 43.2–73.0)
Positive
24 May 2024
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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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