Delving into the Latest Updates on Calcium Acetate with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Acetate of lime, Brown acetate of lime, Calcium Acetate Granules

+ [13]

Target

Phosphates

Action

modulators

Mechanism

Phosphates modulators(Phosphates modulators)

Therapeutic Areas

Endocrinology and Metabolic DiseaseUrogenital Diseases

Active Indication-

Inactive Indication

HyperphosphatemiaKidney Failure, Chronic

Originator Organization

Fresenius Kabi AG

Active Organization-

Inactive Organization

Fresenius Medical Care North America Holdings LP

License Organization-

Drug Highest PhaseApproved

First Approval Date

United States (10 Dec 1990),

Hyperphosphatemia

RegulationOrphan Drug (United States)

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Structure/Sequence

Molecular FormulaC4H8CaO4

InChIKeyWGTHSEQMDUDZLL-UHFFFAOYSA-N

CAS Registry62-54-4

View All Structures (2)

[Translation] A single-center, randomized, open-label, three-period crossover phase I clinical study to evaluate the effects of calcium-containing phosphate binder calcium acetate tablets and non-calcium-containing phosphate binder sevelamer carbonate tablets on the pharmacokinetics of dedostat tablets in healthy subjects

主要目的：评估磷结合剂碳酸司维拉姆片和醋酸钙片对德度司他片药动学的影响。次要目的：观察受试者给予磷结合剂碳酸司维拉姆片和醋酸钙片与德度司他片的安全性。

[Translation]

Primary objective: To evaluate the effect of phosphate binders sevelamer carbonate tablets and calcium acetate tablets on the pharmacokinetics of depo-depo-depo-depo-depo-depo-depo-depo-depo-depo-de- ...

Start Date13 Jul 2023

Sponsor / Collaborator

Yiqiao Hunan Pharmaceuticals Co. Ltd.

ChiCTR2300072509

/ SuspendedPhase 1IIT

A Single-site, Randomized, Open-label, Three-cycle-crossover Phase I Clinical Study to Evaluate the Pharmacokinetics of the Calcium-containing Phosphate Binder Calcium Acetate Tablets and the Non-calcium-containing Phosphate Binder Sevelamer Carbonate Tablets on Desidustat Tablets in Healthy Subjects

Start Date03 Jul 2023

Sponsor / Collaborator-

100 Clinical Results associated with Calcium Acetate

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100 Translational Medicine associated with Calcium Acetate

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100 Patents (Medical) associated with Calcium Acetate

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227,800

Literatures (Medical) associated with Calcium Acetate

31 Dec 2025·Green Chemistry Letters and Reviews

State-of-the-art mean centering of ratio spectra and HPLC methodologies for comprehensive analysis of some dry eyes drugs: investigation of white and green practices

Author: Alsehli, Bandar R. ; Mohamed, Mahmoud A. ; Saleh, Sayed M. ; Allam, Ahmed A. ; Rudayni, Hassan A. ; Alminderej, Fahad M. ; Alwaili, Maha A.

White and green chem. contribute significantly to improving the sustainability of the chem. industry.Based on green and white metrics, ten sustainability tools have been developed.Several tools were used to evaluate how environmentally friendly, innovative as well as forthright RP-HPLC and mean centering of ratio spectra (MCR) techniques were used to simultaneously analyze and sep. sodium hyaluronate (SDH) and benzalkonium chloride (BNZ) in eye drops.An HPLC study utilizing 0.07 M sodium sulfate adjusted to pH 3.0 and Ethanol (90:10, volume/volume) with 205 nm UV detection used an isocratic approach.The experiment used a Partisil Hichrom SCX column (150 mm x 4.6 mm, 5μm), 20μL injection volume, and a 0.8 mL/min flow rate.The column oven was set at 25°C for each sequence.With the aid of the MCR spectral method, the overlapping of the medication' spectral parameters was efficiently resolved.This technique enabled SDH and BNZ to distinguish at 222.1 and 215 nm wavelengths.HPLC and MCR calibration curves revealed a correlation coefficient exceeding 0.999 for all medications between 10-200μg/mL and 5-30μg/mL.The approach produces good recovery results with 98% to 102%.The proposed approach has been validated following ICH principles.

31 Dec 2025·CyTA - Journal of Food

Phytochemical composition, phytotoxicity, and ADME modeling of Artemisia absinthium L.: implications for food safety and pharmaceutical applications

Author: Mothana, Ramzi A. ; Hbika, Asmae ; Farihi, Ayoub ; Gharibi, Elkhadir ; Ed-darraz, Fatima-Zahrae ; Hawwal, Mohammed F. ; Benali, Mohammed ; Bouyanzer, Abdelhamid

Artemisia absinthium, an aromatic herb distinguished by its characteristic bitter flavor, has been used in a variety of culinary applications.This study investigates its metabolites through phytochem. methods.The primary minerals in Artemisia absinthium stems are potassium (41%) and calcium (38.3%), forming most of its mineral content.The ethanolic extract exhibited the highest phenolic compound content, with 37.6 ± 0.09 mg GAE/g DE.The primary volatile compound identified was β-thujone, comprising over 26.6% of the volatile content.Palmitic acid is the predominant fatty acid in the hexanic extract (18.7%), while linoleic acid is the main fatty acid in the Et acetate extract (42.4%).Twenty phenolic compounds were identified, with 8-methoxyflavone, (+)-catechin hydrate, and chlorogenic acid as major compounds in dichloromethane, Et acetate, and ethanol extracts, resp.ADME modeling indicating that 8-methoxyflavone, a major component in the dichloromethane extract, is a promising candidate for drug development targeting the central nervous system.

31 Dec 2025·Italian Journal of Animal Science

Digestion, faeces microbiome, and selected blood parameters in dogs fed extruded food containing Black soldier fly ( Hermetia illucens ) meal

Author: Ahmed, Ibrar ; Kahraman, Oğuzhan ; Kara, Kanber ; Yilmaz Öztaş, Sena ; Alataş, M. Selçuk ; İnal, Fatma ; İnanç, Zekeriya Safa

The Hermetia illucens larva meal up to 15% in dog food linearly increased the molarities of acetic and propionic acids in faeces.The relative abundance of Phascolarctobacterium, Megamonas, Collinsella and Fournierella genera was higher in faecal by 7.5% Hermetia illucens in dog food.Blood IgE, BUN, creatinine, AST, ALT, cholesterol and triglyceride concentrations did not change by dietary Hermetia illucens larva meal.The extruded food containing up to 15% larva meal did not alter nutrient digestibility, body weight and faecal score in large breed dogs.

100 Deals associated with Calcium Acetate

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External Link

KEGG	Wiki	ATC	Drug Bank
D00931	Calcium Acetate	V03AE07	DB00258

R&D Status

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT04485039 (CTgov)	Phase 4	Smallpox	44	Tecovirimat (TPOXX: Oral Antiviral)	(cnsmnpembo) = vbhyjxmtgq gbymcqjgrq (irkksaydme, hnxmlrlltj - shjdkkwnwu) View more	-	09 Oct 2024
				Tecovirimat+sevelamer carbonate oral tablet (TPOXX: Oral Antiviral and Sevelamer Carbonate)	anizykepeg(wnjsacsppa) = jucxvcheuy xhnrtuwjkw (fxobafvlzl, fmxooknciy - zodkrurlgd) View more
ASN2021	Not Applicable	Chronic Kidney Diseases	-	Calcium acetate	wtkzhoatgn(ecohcajwfn) = itpfecxesl pdptnoxhpu (fjwmviudzc )	-	27 Oct 2021
				Ferric citrate	wtkzhoatgn(ecohcajwfn) = fvefucmglo pdptnoxhpu (fjwmviudzc )
ASN2020	Not Applicable	-	2,018	Sucroferric Oxyhydroxide (SO)	deitvarous(mdzqmrtzgu) = ggspalixme txymjvsujw (kzlafnomre ) View more	Positive	19 Oct 2020
				Calcium Acetate	deitvarous(mdzqmrtzgu) = moiierwbrf txymjvsujw (kzlafnomre ) View more
ASN2016	Not Applicable	-	139	Calcium Acetate	tlvibuilyu(jsgcfjhsaz) = wcpamxdxpz rwshphgfoi (npgvqtdnvm )	Positive	15 Nov 2016
				Sucroferric Oxyhydroxide	tlvibuilyu(jsgcfjhsaz) = iydscddfaw rwshphgfoi (npgvqtdnvm )
ASN2016	Not Applicable	Hyperphosphatemia	4,674	Sevelamer	(ppuqqrnviq): HR = 0.64 (95% CI, 0.45 - 0.91), P-Value = 0.012	Positive	15 Nov 2016
				Calcium Acetate
ASN2015	Not Applicable	-	-	Calcium acetate	zauiflcfbc(riucnibwnr) = ucrmbjvefj ewckcdfxgo (pbvluwmwek ) View more	Positive	03 Nov 2015
				Calcium carbonate	zauiflcfbc(riucnibwnr) = pumjtpdwbs ewckcdfxgo (pbvluwmwek ) View more
VIKI Study (ASN2013)	Not Applicable	Chronic Kidney Diseases BGP \| MGP	387	Calcimimetics	hdkfyhvoak(fsebjknppk) = jdnpmwgaoa hcpjbaqyia (howllskjfs )	Positive	05 Nov 2013
				Vitamin D analogs	hdkfyhvoak(fsebjknppk) = oppcqxelmq hcpjbaqyia (howllskjfs ) View more
ASN2013	Not Applicable	Kidney Failure, Chronic serum Ca \| PO4 \| ALP ... View more	150	Calcium Acetate	hbwmzvipee(hbzaukklko) = yffkfikgyf hezodsufvw (dogdruoeci ) View more	Positive	05 Nov 2013
				Sevelamer Carbonate	hbwmzvipee(hbzaukklko) = aowutrxjeu hezodsufvw (dogdruoeci ) View more
NCT01135615 (Pubmed \| Am J Kidney Dis)	Phase 4	Chronic Kidney Diseases	100	Sevelamer	zjikufykhg(oobvmcgvzf) = xesonxjluv xyadwfhyfi (hkqgohbsox )	-	01 Feb 2012
				Calcium Acetate	zjikufykhg(oobvmcgvzf) = vzxaqskqbg xyadwfhyfi (hkqgohbsox )
NCT00211978 (Pubmed)	Phase 3	Chronic Kidney Diseases	110	Calcium acetate	(jvmakslgel) = wcdsvdhxjw mcjjwqsewf (hfodfhpmoh )	Positive	16 Feb 2011
				Placebo	(jvmakslgel) = fnqoxpqpsi mcjjwqsewf (hfodfhpmoh )