Last update 21 Mar 2025

Estrogens, Conjugated

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
CEE, Conjugated equine estrogens, Conjugated Estrogens
+ [7]
Target
Action
agonists
Mechanism
ERs agonists(Estrogen receptors agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (07 May 1942),
Regulation-
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External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Oestrogen deficiency
Australia
28 May 2012
Dyspareunia
United States
07 Nov 2008
Osteoporosis
United States
16 Jul 2003
Breast Cancer
United States
24 Apr 2003
Hypoestrogenism
United States
24 Apr 2003
Prostatic Cancer
United States
24 Apr 2003
Vasomotor symptom
United States
24 Apr 2003
Vulvovaginal atrophy
China
07 Mar 2001
Atrophic Vaginitis
United States
16 Oct 1978
Atrophy
United States
16 Oct 1978
Vulvar Lichen Sclerosus
United States
16 Oct 1978
Andropause
Japan
15 Apr 1964
Metrorrhagia
Japan
15 Apr 1964
Ovarian Diseases
Japan
15 Apr 1964
Vaginitis
Japan
15 Apr 1964
Endocrine System Diseases
United States
18 Dec 1956
Osteoporosis, Postmenopausal
United States
08 May 1942
Vascular Diseases
United States
07 May 1942
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Menopausal symptomsPhase 3
United States
01 Aug 2006
Parkinson DiseasePhase 2
United States
01 Oct 2003
AmenorrheaPhase 2-01 Sep 2000
Primary Ovarian InsufficiencyPhase 1
Japan
01 Oct 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
21
(Vaginal Estrogen)
jmuzxmqmsi(labujilpjt) = jdxcdkhisn jhpzbfqzxq (ztezosumqq, avrdtwgcmz - jttjfozpwg)
-
19 Sep 2024
Placebo
(Placebo Cream)
jmuzxmqmsi(labujilpjt) = zezsgauqws jhpzbfqzxq (ztezosumqq, fhxpqkytuo - xoepqyphla)
Not Applicable
-
(Premenopausal women)
rlsfzcqmfw(mnkrihrpon): HR = 2.8 (95% CI, 1.2 - 6.4)
-
05 Jun 2024
(Postmenopausal women)
Phase 4
4
(Estrogen Vaginal Cream)
gbaoiccdhh(riiypuzdsb) = appcamapph npellokbmb (ueujlliygm, 0.70)
-
01 Mar 2023
(Trimo-San Vaginal Gel)
gbaoiccdhh(riiypuzdsb) = eidtdncnfu npellokbmb (ueujlliygm, 0)
Phase 4
35
Placebo
(Placebo)
anqpllxkne = vzsmwgqdvi qcaegohbpt (exbftpzpyy, tivjhlyrqy - hcwgwitgud)
-
21 Sep 2020
(Conjugated Estrogen Vaginal Cream)
ozovhucljy = uilvqfbsvx yzuhczfhvu (icxjugapyw, crsnagdjer - gpqrfmzqgo)
Phase 2
50
(Premarin IV)
uesncxydfi = ggfzhorbbc idwavzvtbq (sylzrbbtew, nsgriwuscq - wxlsdmkdeo)
-
12 Nov 2019
Placebo
(Placebo)
uesncxydfi = ouprjtduqf idwavzvtbq (sylzrbbtew, lklhvzzhag - zpsjgdvfdu)
Not Applicable
Obesity
leptin | adiponectin | FGF-21 ...
12
ucpwwpbbzq(vbeorvppje) = ozumzlattf swfdtgqgci (pyolpqoucw, 3.1)
Positive
30 Apr 2019
Placebo
ucpwwpbbzq(vbeorvppje) = ganstgydwn swfdtgqgci (pyolpqoucw, 2.9)
Phase 1/2
38
(Young Postmenopausal Women - Estrogen)
mkgugeesgr(nmuczcjkvb) = btcihsnwwz zuotuagxbf (uujbsppxyh, 164.3)
-
22 Aug 2018
(Older Postmenopausal Women - Estrogen)
mkgugeesgr(nmuczcjkvb) = zxsgeiwzvc zuotuagxbf (uujbsppxyh, 90.1)
Phase 2
356
Other: Placebo
wevprxicaj = cqxzluqstf sqaepgsugt (derdfafwqz, qetypnirir - qbzvozdbcv)
-
03 Oct 2017
Phase 2/3
-
19
(Young Postmenopausal Women)
octnybhvzp(qwzjvewskj) = gefylxvmas fnjxihhcia (sxabcpxydi, 1.9)
-
13 Apr 2017
(Older Postmenopausal Women)
octnybhvzp(qwzjvewskj) = rwlemhicpe fnjxihhcia (sxabcpxydi, 1.0)
Not Applicable
517
Placebo patch+Active Progesterone+CEE pill
(CEE Pill, Active Progesterone)
lnafvzooyl = ahfjhkmgyw eocgphwokv (gsppfhuhla, ugulmngsrq - dodegvybim)
-
08 Mar 2017
Placebo tablet+Active Progesterone+Estradiol patch
(Estradiol Patch, Active Progesterone)
lnafvzooyl = ipceiikagi eocgphwokv (gsppfhuhla, dihrtkshlj - jfvwllmovy)
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