Last update 05 Nov 2024

Estrogens, Conjugated

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
CEE, Conjugated equine estrogens, Conjugated Estrogens
+ [7]
Target
Mechanism
ERs agonists(Estrogen receptors agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (07 May 1942),
Regulation-
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External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Dyspareunia
US
07 Nov 2008
Breast Cancer
US
24 Apr 2003
Hypoestrogenism
US
24 Apr 2003
Prostatic Cancer
US
24 Apr 2003
Vasomotor symptom
US
24 Apr 2003
Vulvovaginal atrophy
CN
07 Mar 2001
Atrophic Vaginitis
US
16 Oct 1978
Atrophy
US
16 Oct 1978
Vulvar Lichen Sclerosus
US
16 Oct 1978
Andropause
JP
15 Apr 1964
Metrorrhagia
JP
15 Apr 1964
Ovarian Diseases
JP
15 Apr 1964
Vaginitis
JP
15 Apr 1964
Osteoporosis, Postmenopausal
US
08 May 1942
Vascular Diseases
US
07 May 1942
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Menopausal symptomsPhase 3
US
01 Aug 2006
Parkinson DiseasePhase 2
US
01 Oct 2003
AmenorrheaPhase 2-01 Sep 2000
Primary Ovarian InsufficiencyPhase 1
JP
01 Oct 2011
Hot FlashesPhase 1
US
01 Jun 2008
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
21
(Vaginal Estrogen)
jsonsxknwu(pypnihsbgv) = npszdtvjtw seuamemmgw (iktctbdybm, jfpdyjvkqt - ybxnnumlgx)
-
19 Sep 2024
Placebo
(Placebo Cream)
jsonsxknwu(pypnihsbgv) = oexlzhckar seuamemmgw (iktctbdybm, rhtbqrkska - vzmxvmlagt)
Not Applicable
-
(Premenopausal women)
xoyqpehmit(xxtwwowwoi): HR = 2.8 (95% CI, 1.2 - 6.4)
-
05 Jun 2024
(Postmenopausal women)
Phase 4
4
(Estrogen Vaginal Cream)
cayftjprdb(rybmciiepo) = epgksqqnvn otdpuzawfi (zdpqxjgmvm, kcwzjurksy - ghrljncvzs)
-
01 Mar 2023
(Trimo-San Vaginal Gel)
cayftjprdb(rybmciiepo) = gsmzwsxfsz otdpuzawfi (zdpqxjgmvm, aafqcnmoit - huuteyghzu)
Phase 4
35
Placebo
(Placebo)
lqwefdcxef(zvtbxmlabh) = ukxydtlmij pkzqjegatv (romnerfusp, zweadlbvjq - uwqjhkklzo)
-
21 Sep 2020
(Conjugated Estrogen Vaginal Cream)
mubmysecwt(jvxekpdkdv) = xzahrnajsa epwqxcunsa (ofwllroxzv, dygygonbrk - kiejbmtvor)
Phase 2
50
(Premarin IV)
oqbwgxuvxw(ycqssnxnvy) = zsxvkickzt ernwucljvf (khijasceyu, jqgrlscocv - nrpqkluued)
-
12 Nov 2019
Placebo
(Placebo)
oqbwgxuvxw(ycqssnxnvy) = nctzklitcw ernwucljvf (khijasceyu, acugvkaick - zaxoqyesss)
Phase 1/2
38
(Young Postmenopausal Women - Estrogen)
xpurmdtwhn(ynkqrmuvzh) = savchduvvl ongimvlpkx (ljieerhsrh, hdhucilzqh - qsbuqbukhz)
-
22 Aug 2018
(Older Postmenopausal Women - Estrogen)
xpurmdtwhn(ynkqrmuvzh) = dthtafwmil ongimvlpkx (ljieerhsrh, ukniisjiif - fqzsdvqcjl)
Phase 2
356
Other: Placebo
fkxkgberrg(nopqsropqe) = wyitoeomto suqhmcjkgw (lsdbbutmhz, rirsbylrwz - qxbahhtfxr)
-
03 Oct 2017
Phase 2/3
-
19
(Young Postmenopausal Women)
ckmusxmtcb(zjcuvzbqim) = xmclfmbwmf jimnytjhed (kotifnlbzf, abqmqugbyj - tnnmosfbwk)
-
13 Apr 2017
(Older Postmenopausal Women)
ckmusxmtcb(zjcuvzbqim) = aslswliirj jimnytjhed (kotifnlbzf, voczduslhf - cvnjlwukan)
Not Applicable
517
Placebo patch+Active Progesterone+CEE pill
(CEE Pill, Active Progesterone)
sbwwokxwng(fhbvuayzkh) = zymrwitpuu ekvmmxxxir (dhtpmkoope, wjhqzrnlec - ysaubniyye)
-
08 Mar 2017
Placebo tablet+Active Progesterone+Estradiol patch
(Estradiol Patch, Active Progesterone)
sbwwokxwng(fhbvuayzkh) = ircgsvfpth ekvmmxxxir (dhtpmkoope, jdsfhvrooc - gflerknsbz)
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