Estrogens, Conjugated

Mumbai: Jenny was there, and so was Justin. Also, Ranveer, Hrithik, Madhuri, Karan and Don Junior. If anyone hasn’t heard of Raj Ramalinga Mantena by now, they’ve been living under the proverbial rock. Over the past few days, the lavish wedding celebrations of the US-based billionaire pharmaceutical entrepreneur ’s daughter in Udaipur have set social media alight. Mantena ’s daughter Netra is tying the knot with Vamsi Gadiraju, a technology entrepreneur who cofounded startup Superorder in the US. For those not familiar with first names, attendees and performers included Jennifer Lopez , Justin Bieber , Ranveer Singh, Hrithik Roshan, Varun Dhavan, Kriti Sanon, Madhuri Dixit and Karan Johar. Donald Trump Jr was there too. But who is Raj Mantena and how did the world miss his meteoric rise? The reclusive, Florida-based Indian-born businessman has been little known outside a circle of close friends in Hyderabad’s pharmaceutical hub. Not anymore, it would seem. ET spoke to people who know him closely to put together a picture of the man who’s behind this latest and most astonishing of spectacles that rivals some other recent nuptial jamborees. Foreseeing the Future “Raju has a king-size taste for luxury. His home at Manalapan (Florida) has a car museum, and the basement has a bar only the elite can think of,” a person told ET. Mantena , a serial healthcare entrepreneur, moved to the US after studying computer science in India, before taking up a pharmacy degree there. His wealth—said to be in billions of dollars—comes from the intersection of these two diverse fields of science that have complemented each other over time. Early breakthroughs in the field of medicine, particularly cancer treatments, the use of digital technology in healthcare services, and rapid changes in reimbursement patterns in the US fuelled Mantena ’s entrepreneurial vision. He entered businesses, scaled them to a size and sold them to large corporations at rich valuations. From cloud-based healthcare solutions for precision medicine through Integra Connect to selling low-priced generic drugs as part of Ingenus Pharmaceuticals, Mantena’s businesses continue to boom. Integra Connect says it’s a value-based precision medicine company that turns real-world data into deep insights in cancer treatment. As part of the oncology care model, Integra says it generated $260 million in value-based care revenue and over $100 million in shared savings for participating companies. OncoScripts, an oncology-focused pharmacy founded by Mantena in the 90s, was later acquired by a subsidiary of pharma distribution heavyweight Cardinal Health. Next, Mantena built International Oncology Network, a group purchasing and oncology community network that was acquired by AmerisourceBergen, now Cencora, in 2001. He then founded ICORE Healthcare, a provider of healthcare plans to manage cost trends in specialty drugs, selling the venture to Magellan Health Services in 2006 for more than $200 million. Home Ties While the businesses thrived in the US, back home in India, Mantena extended his connections deeper into Andhra Pradesh political circles. “The Mantena family is related to the Gokaraju family,” which carries political heft in Andhra Pradesh, said a person in Hyderabad. Several top executives in the US and in the Indian pharmaceutical industry said they hadn’t heard much about the man. “At an international conference on precision medicine in Orlando recently, I do not remember seeing a representative from Integra Connect,” said a senior business development executive in the field of oncology. Similar notes came from another biotech entrepreneur, based in San Francisco for over three decades. A November 13 release from Ingenus showed the company secured approval from the US Food and Drug Administration (FDA) for the only generic equivalent of Premarin, a tablet used for treating osteoporosis and a few effects of menopause. Mantena’s profile on LinkedIn shows only a few connections and it is learnt that he uses the networking site sparingly. Still, the extravagant festivities in Udaipur will ensure the name won’t be easily forgotten. By Vikas Dandekar ,

NEW YORK--(BUSINESS WIRE)--Evvy, the vaginal microbiome company pioneering biomarker-driven women’s healthcare, today announced the launch of a new Estradiol Vaginal Cream — uniquely formulated without parabens or sulfates. The Estradiol Vaginal Cream is offered alongside Evvy’s Vaginal Health Test and Clinical Care platform, enabling a first-of-its-kind, personalized, and holistic approach to vaginal changes in menopause. Together, the test and treatments enable personalized insights and ongoing care grounded in the latest vaginal microbiome science. This launch expands Evvy’s growing suite of menopause-focused Rx solutions, including its Soothing Vulva Cream and hormone-free Hyaluronic Acid Suppositories. Up to 84% of women experience vaginal and urinary symptoms during menopause, yet these changes remain some of the least effectively treated in healthcare. That’s because vaginal estrogen impacts two deeply connected systems: the health of the vaginal tissue and the balance of the vaginal microbiome. Most menopause solutions focus only on replenishing tissue moisture, overlooking how shifts in bacteria and pH can drive irritation, infection, and discomfort. Evvy takes a holistic approach to support both tissue and microbial health, helping menopausal women finally get care that treats the root cause, not just the symptoms. “With this launch, we’re bringing precision medicine to one of the most overlooked phases of women’s health,” said Priyanka Jain, Co-Founder and CEO of Evvy. “By integrating hormone care with vaginal microbiome insights, we can finally address the root causes of menopausal discomfort—not just the symptoms.” Most generic estradiol creams prescribed today contain parabens, sulfates, and other irritants that are known to disrupt the vaginal microbiome. Evvy’s new compounded formula, created by the scientific team behind the world’s leading vaginal microbiome test, is free from parabens, sulfates, and unnecessary additives. Pure, Prescription-Grade Relief: Compounded in a 503a NABP-accredited pharmacy, with no parabens, sulfates, or unnecessary additives Holistic, Integrated Care: Delivered through Evvy’s precision health platform, the program combines pure, low-dose vaginal estrogen with advanced vaginal microbiome testing and personalized care. By addressing both tissue health and microbial balance, Evvy takes a truly comprehensive approach to vaginal symptoms in menopause. Accessible, At-Home Support: From testing to treatment to ongoing guidance, Evvy makes care for vaginal health in menopause seamless, affordable, and completely at home—so women can access evidence-based relief without stigma or inconvenience. “Vaginal estrogen is one of the most effective – and underused – tools for restoring comfort after menopause,” said Dr. Kate McLean, OB-GYN and Chief Medical Officer at Evvy. “What makes Evvy’s formulation different is its commitment to an estrogen option with no parabens and sulfates — delivering the same effective relief from dryness and discomfort, without the unnecessary additives found in most generics.” This launch further solidifies Evvy’s mission to transform overlooked female biomarkers into precision care pathways across every stage of life. Since 2021, Evvy has pioneered the world’s first CLIA-certified at-home vaginal microbiome test, built the largest real-world dataset on the vaginal microbiome, and scaled a care platform that integrates testing, personalized prescriptions, and 1:1 coaching. With menopause representing one of the most significant gaps in women’s health, the Estradiol Vaginal Cream signals a natural and strategic expansion for Evvy and its patients. The Estradiol Vaginal Cream is now available nationwide at www.evvy.com. About Evvy: Founded in 2021, Evvy is closing the gender health gap by leveraging overlooked female biomarkers, starting with the vaginal microbiome. The company offers the world’s first Vaginal Microbiome Test powered by metagenomic sequencing, analyzing over 700 microbes with a single, at-home swab — including those related to bacterial vaginosis, yeast infections, fertility outcomes, and more. Evvy’s care platform also includes precision treatment pathways from licensed clinicians and 1:1 health coaching. Through their test and care platform, Evvy has built the world’s largest dataset on the vaginal microbiome, and they are leveraging this novel data to improve outcomes across women’s health.