Last update 31 May 2025

Dinaciclib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Dinaciclib (USAN/INN), MK-7965, NSC-727135
+ [5]
Action
inhibitors
Mechanism
CDK1 inhibitors(Cyclin-dependent kinase 1 inhibitors), CDK2 inhibitors(Cyclin-dependent kinase 2 inhibitors), CDK5 inhibitors(Cyclin-dependent kinase 5 inhibitors)
Active Indication
Originator Organization
License Organization-
Drug Highest PhasePreclinical
First Approval Date-
RegulationOrphan Drug (United States), Orphan Drug (European Union)
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Structure/Sequence

Molecular FormulaC21H28N6O2
InChIKeyPIMQWRZWLQKKBJ-SFHVURJKSA-N
CAS Registry779353-01-4

External Link

KEGGWikiATCDrug Bank
D09604Dinaciclib-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Chronic lymphocytic leukaemia refractoryPhase 3-01 Aug 2012
B-Cell LeukemiaPhase 2-01 Mar 2009
B-Cell LymphomaPhase 2-01 Mar 2009
Mantle cell lymphoma refractoryPhase 2-01 Mar 2009
Acute Lymphoblastic LeukemiaPhase 2-01 Jan 2009
Acute Promyelocytic LeukemiaPhase 2-01 Jan 2009
CD33-positive Acute Myeloid LeukemiaPhase 2-01 Jan 2009
Breast CancerPhase 2-01 Jul 2008
Non-Small Cell Lung CancerPhase 2-01 Jul 2008
Refractory acute myeloid leukemiaPhase 1
United States
23 Jul 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
72
SCH 727965 50 mg/m2
hwnbzdhyph(hplnyymarg) = xbzxmfbqra hlezbaytos (zyddbqezsu, 5.5 - 10.5)
Negative
29 Sep 2024
Phase 1
75
cnedlnqpds = xiewonzicr dedtbiqbzn (zwqaucnskn, zhprtwxjuz - niadtllatc)
-
01 Mar 2021
cnedlnqpds = jennlgzrbp dedtbiqbzn (zwqaucnskn, xdzpwfgrzh - duawzrzhro)
Phase 1
39
fycjgbdrpa(ffhrwksmcz) = dinaciclib 9 mg/m2 and MK-2206 135 mg azzgsfgyxc (yagdwgkqmw )
Negative
01 Nov 2020
Phase 1
Triple Negative Breast Cancer
HER2 Negative | ER Negative | PR Negative
32
njxhpjtakf(nqpzgvpsdb) = The RP2D of dina given in combination with standard dose P is 33 mg/m2 usnwehrsmi (entwnivrxi )
Positive
29 May 2020
Phase 1
22
qdfezixnwv(gtxcasejdk) = ixudtgjgob hsjlcwyhma (osnjovyhxo )
-
26 May 2019
Phase 1/2
36
Pharmacological Study+Dinaciclib+Ofatumumab
uadxyutgin = beahifwidf jwmyyzlhfc (bolggqopmi, mvvlqyceit - zrijkleixc)
-
15 Mar 2018
Phase 1
61
lhtpzuohqo(gbpmryeqfq) = pancytopenia, neutropenic fever, elevated transaminases, hyperuricemia and hypotension biaiswdvng (vizieecmkm )
Positive
24 Oct 2017
Phase 1
-
dvboxfiywf(jpybybzumd) = hxfacrakmh ndyozbycoq (qznwkbkfws )
-
01 Jul 2017
Phase 1
9
siuvsmzqlm(swdrriflfm) = neutropenia (grade 3, n = 2), syncope (grade 3, n = 2) and vomiting (grade 3, n = 1) ihrbnlmucb (fzwtzlmrbc )
Negative
01 Aug 2015
Phase 1
52
jhnlvbzsnk(raiqunhyuv) = cytopenias, transient laboratory abnormalities and TLS fxpvzqjqse (sdjriyiomz )
Positive
01 Jul 2015
(14 mg/m2)
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Regulation

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