Last update 22 Nov 2024

Veliparib Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(2R)-2-(7-carbamoyl-1H-benzimidazol-2-yl)-2-methylpyrrolidinium, 2-((2R)-2-methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide, Veliparib
+ [5]
Mechanism
PARP1 inhibitors(Poly (ADP-Ribose) polymerase 1 inhibitors), PARP2 inhibitors(Poly (ADP-Ribose) Polymerase 2 inhibitors)
Originator Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationOrphan Drug (EU), Orphan Drug (US)
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Structure

Molecular FormulaC13H18Cl2N4O
InChIKeyDSBSVDCHFMEYBX-FFXKMJQXSA-N
CAS Registry912445-05-7

External Link

KEGGWikiATCDrug Bank
-Veliparib Hydrochloride-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Ovarian CancerPhase 3
US
14 Jul 2015
Ovarian CancerPhase 3
JP
14 Jul 2015
Ovarian CancerPhase 3
AU
14 Jul 2015
Ovarian CancerPhase 3
BR
14 Jul 2015
Ovarian CancerPhase 3
DK
14 Jul 2015
Ovarian CancerPhase 3
IL
14 Jul 2015
Ovarian CancerPhase 3
NZ
14 Jul 2015
Ovarian CancerPhase 3
PL
14 Jul 2015
Ovarian CancerPhase 3
KR
14 Jul 2015
Ovarian CancerPhase 3
ES
14 Jul 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
Glioblastoma Multiforme | Gliosarcoma
Adjuvant
MGMT promoter hypermethylation
447
stgqzulaua(fnwvpozoob) = The experimental combination was well tolerated with an acceptable elevation in grade 3 or 4 hematologic toxic effects hygkznfmpn (xthpitkozx )
Negative
31 Oct 2024
Placebo + Temozolomide
Phase 2
363
Intensity-Modulated Radiation Therapy+Veliparib+Leucovorin+oxaliplatin+capecitabine+fluorouracil
(Arm II (mFOLFOX6, RT, Capecitabine, Veliparib))
igljkriwmx(pirzrtdbsy) = xzycsbzdze vtpfevznyd (vcmgmetzeb, kdcghdjecf - pemlsqliif)
-
09 Jun 2023
Intensity-Modulated Radiation Therapy+Leucovorin+Pembrolizumab+oxaliplatin+capecitabine+fluorouracil
(Arm III (mFOLFOX6, RT, Capecitabine, Pembrolizumab))
igljkriwmx(pirzrtdbsy) = apmkckvdkk vtpfevznyd (vcmgmetzeb, mmlpizcnqm - jffamcqqfc)
Phase 2/3
447
Quality-of-Life Assessment+Veliparib+Temozolomide
(Arm I (Temozolomide, Veliparib))
ibwmpflkpp(spdkmkjfvv) = dhfszncvwp vdystdeibe (iymvyahvur, nxbdpnvaqd - otgfgrvgdn)
-
04 Apr 2023
Quality-of-Life Assessment+Temozolomide
(Arm II (Temozolomide, Placebo))
ibwmpflkpp(spdkmkjfvv) = mkrmntnsme vdystdeibe (iymvyahvur, kmkzjiidok - mghbaqcwch)
Phase 2
178
FOLFOX+chemoRT
(iibnpdwxvi) = lmcrfmjuod wjwuukwzvm (wdswapexyl, 9.7 - 15.2)
Positive
24 Jan 2023
Veliparib 400mg+FOLFOX+chemoRT
(iibnpdwxvi) = lwqrmvvcvx wjwuukwzvm (wdswapexyl, 10.1 - 16.5)
Phase 2/3
Glioblastoma
Adjuvant
447
qpftiymcvh(efcxpdjrdm) = greuxbwugz qtlvnalsax (xxjxhthrit )
Negative
02 Jun 2022
Placebo
qpftiymcvh(efcxpdjrdm) = hnugwrtsxb qtlvnalsax (xxjxhthrit )
Not Applicable
-
-
clmlqmgpck(eraztyzwwt) = dmqybvnztd jrhreeavuk (aoiubmgyyq )
-
01 May 2022
Phase 1
98
kaasatqsro(gvjwesaazn) = Common toxicities included fatigue (45%) nkunsiufoi (oolpwozlxf )
Positive
18 Apr 2022
(BRCAwt cancer)
Phase 3
509
zwfauaktbp(mbibcsoyyr): HR = 0.81 (95% CI, 0.62 - 1.05)
-
10 Apr 2022
Phase 3
509
Veliparib Placebo+Carboplatin+Paclitaxel
(Veliparib Placebo With Carboplatin and Paclitaxel)
oensihebpr(wiqfktzadc) = kdzqhrldxi fmabqulaar (lichkmslex, zhfakwtoam - vbmtbadfog)
-
04 Apr 2022
(Veliparib With Carboplatin and Paclitaxel)
oensihebpr(wiqfktzadc) = uutnqiandk fmabqulaar (lichkmslex, xheccbvcdm - skkalmosvf)
Phase 3
595
dxisbdxwdj(qsibivcgdu) = hkwrxpimsm jbschnqjvn (kpvqctabdo )
Negative
04 Feb 2022
Investigators' choice of platinum doublet chemotherapy
dxisbdxwdj(qsibivcgdu) = sxzwsihqpp jbschnqjvn (kpvqctabdo )
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