Drug Type Small molecule drug |
Synonyms ABT 751, E 7010, E-7010 |
Target |
Mechanism Tubulin inhibitors |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhaseDiscontinuedPhase 2 |
First Approval Date- |
Regulation- |
Molecular FormulaC18H17N3O4S |
InChIKeyURCVCIZFVQDVPM-UHFFFAOYSA-N |
CAS Registry141430-65-1 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Advanced Lung Non-Small Cell Carcinoma | Phase 2 | US | 01 Nov 2006 | |
Advanced Lung Non-Small Cell Carcinoma | Phase 2 | CZ | 01 Nov 2006 | |
Advanced Lung Non-Small Cell Carcinoma | Phase 2 | GR | 01 Nov 2006 | |
Advanced Lung Non-Small Cell Carcinoma | Phase 2 | HU | 01 Nov 2006 | |
Advanced Lung Non-Small Cell Carcinoma | Phase 2 | NL | 01 Nov 2006 | |
Advanced Lung Non-Small Cell Carcinoma | Phase 2 | SK | 01 Nov 2006 | |
Recurrent Adult Acute Lymphoblastic Leukemia | Phase 2 | US | 22 May 2006 | |
Non-Small Cell Lung Cancer | Phase 2 | US | 01 Sep 2003 | |
Refractory Colorectal Carcinoma | Phase 2 | US | 01 Aug 2003 | |
Refractory Colorectal Carcinoma | Phase 2 | CA | 01 Aug 2003 |
Phase 1/2 | 9 | PEG-asparaginase+CYCLOPHOSPHAMIDE+doxorubicin+6-thioguanine+Dexamethasone+Methotrexate+Cytarabine+ABT-751 (Dose Level 1) | usrkfijhyu(ytcuqyizhx) = slcqsiavsp jumszetslh (uhsvvuqgoq, aubqihwzjm - sszxgtalmr) View more | - | 09 Sep 2020 | ||
PEG-asparaginase+CYCLOPHOSPHAMIDE+doxorubicin+6-thioguanine+Dexamethasone+Methotrexate+Cytarabine+ABT-751 (Dose Level 0) | usrkfijhyu(ytcuqyizhx) = fwmmxcycfy jumszetslh (uhsvvuqgoq, mciaaeibtm - ubwvecqqvz) View more | ||||||
Phase 2 | 92 | I-MIBG+ABT-751 (Disease Evaluable by I-MIBG Scintigraphy (ABT-751)) | mvhteilbdq(rjcneqamfn) = ddsgcjaypg ppssdaawrv (csttumxwvm, ylcameuyfi - eputlktqyu) View more | - | 28 Feb 2014 | ||
(Measurable Disease by CT or MRI Scan (ABT-751)) | mvhteilbdq(rjcneqamfn) = ygmldnvppm ppssdaawrv (csttumxwvm, taiaqloqxk - behsrtwzpz) View more | ||||||
Phase 1/2 | 27 | (ABT-751) | djntmdkkgh(lrotdowqva) = cmxibpldai ckqtvplxci (ccbqikconv, jugufluszy - boleopwcls) | - | 27 Jun 2012 | ||
(Phase I/11: ABT-751) | rnqftgrfru(ctvypwbjco) = aycpdrzsos wzlaoewioq (wukvdlzgtd, vlmbxcsznp - rpktovjyau) View more | ||||||
Phase 1 | 20 | frrodnluum(srbymmmyte) = xiloqjopty mptskjqnsk (vagjiibheq, 5.9 - 27.0) View more | Positive | 01 Jan 2012 | |||
Phase 1/2 | 165 | znzcxfidku(paaidaujsg) = pviobddepm rdjkldkcoq (myyejgiugs ) View more | - | 10 Mar 2011 | |||
Pemetrexed + Placebo | znzcxfidku(paaidaujsg) = ihbosphufg rdjkldkcoq (myyejgiugs ) View more | ||||||
Phase 1 | - | rxbadrmafi(tnunhrvvqv) = eowhmwhqej odbazljgki (niauqhirik ) | - | 15 Feb 2008 | |||
Phase 1 | - | oayxgqezvg(jebnwtxgpg) = weqyohwhme zzaolpbaos (etbwhmdklk ) View more | - | 15 Aug 2006 | |||
Phase 1 | 18 | xpafjuvivg(qpwnatiefr) = webxwtcawc xcuhktbdzw (hskqnevvsu ) | - | 20 Jun 2006 | |||
Phase 1 | 40 | ivczjgqrrv(zhcvtqgeof) = dscnmxtwlj fcylkijkux (tlanbzqtnv ) View more | - | 01 Jun 2005 | |||
Phase 2 | 18 | mvxlpssyef(ixzcwjwhwl) = uwmkstfuda ijevgjbmcy (btwgyszxql ) View more | Negative | 01 Jun 2005 |