Drug Type Small molecule drug |
Synonyms 2-Amino 6MP, 2-Amino-1,7-dihydro-6H-purine-6-thione, 2-amino-1,9-dihydropurine-6-thione + [22] |
Target |
Mechanism DNA inhibitors(DNA inhibitors) |
Therapeutic Areas |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date |
RegulationOrphan Drug (EU) |
Molecular FormulaC5H5N5S |
InChIKeyWYWHKKSPHMUBEB-UHFFFAOYSA-N |
CAS Registry154-42-7 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D06109 | Thioguanine |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Acute Lymphoblastic Leukemia | CN | 01 Jan 1995 | |
Acute Myeloid Leukemia | US | 18 Jan 1966 | |
Philadelphia chromosome positive chronic myelogenous leukemia | US | 18 Jan 1966 |
Phase 3 | 669 | Asparaginase+etoposide+CYCLOPHOSPHAMIDE+Leucovorin Calcium+pegaspargase+Therapeutic Hydrocortisone+Mitoxantrone+Dexamethasone+Vincristine Sulfate+Methotrexate+Cytarabine (Arm A (HR and IR Control)) | qmijzamxsx(qvkbzxaoyx) = dnlqcoltly wtooycocdu (lwovfrlxse, vbmtdcowss - pkyflkzprs) View more | - | 06 Dec 2022 | ||
(Arm B (HR and IR Blinatumomab)) | qmijzamxsx(qvkbzxaoyx) = xzydxcymmd wtooycocdu (lwovfrlxse, eejdpvtqma - swyaspjpgi) View more | ||||||
Phase 2 | 78 | HC+cyclophosphamide+PEG+leucovorin calcium+thioguanine+6-MP+dexamethasone+MTX+vincristine sulfate+daunorubicin hydrochloride+ARA-C (KMT2A-Rearranged) | xxpapvmwiz(epemszpcek) = gtzqpqubdv nfvgjruofk (jgyrlscwuu, gmsqcaddeu - qazptzjsfn) View more | - | 26 Oct 2021 | ||
cytarabine (ARA-C)+prednisolone+dexamethasone+vincristine sulfate+Methotrexate+daunorubicin hydrochloride (KMT2A-Germline) | ftbgrdjxhh(dqqtstljve) = xdxisbmyog xyuhkkyjfd (nnhuvzdvzo, stfhtveupo - kpvftcuuaf) View more | ||||||
Phase 2 | 120 | vhhrfuyelz(gnnwbpgyqu) = uwxuywhnrp tcwuykrhot (qhydzzgref, qajlpfqnmd - utnedrrwdc) View more | - | 10 Sep 2019 | |||
Phase 2 | 1 | Ofatumumab | fckiykzdbr(qvejiafudj) = dvdwukmquz qwbsiiehhz (gxsfvnonin, thflqahgth - mbpxztermm) View more | - | 11 Jun 2018 | ||
Phase 2 | 5 | vizfasgdwf(qdniozzzrt) = wezbwkbaaq iqgzmqnpti (aykfoldujh, qubgvkcmyq - hjozhcfljo) View more | - | 04 May 2015 | |||
Phase 3 | 205 | laboratory biomarker analysis+etoposide+asparaginase+thioguanine+Cytarabine+daunorubicin hydrochloride | amlryhkzbl(tweuiqeryr) = zjaulwnczd ojsxhplsmi (opwenrjsmi, itkbwnuudj - abjkrufmsx) View more | - | 13 Jan 2015 | ||
Phase 2 | 60 | Daunomycin+Cyclophosphamide+leucovorin+Hydrocortisone+6-thioguanine+aminopterin+6-mercaptopurine+dexamethasone+Vincristine+Methotrexate+Cytarabine+L-Asparaginase (Arm 2 High Risk) | olfjqsmayu(zppfidjrym) = nbbtimrnuu ajocatdfex (djmqlmulnw, ynyiicctgz - yoqunekicx) View more | - | 09 Jun 2014 | ||
Daunomycin+leucovorin+Hydrocortisone+6-mercaptopurine+dexamethasone+Methotrexate+Vincristine+Cytarabine+L-Asparaginase (Arm 1 Standard Risk) | ijovuuofim(xzuqdpsaho) = rbjkworbws lzaicvfdfy (exlaannzue, wcdpdixpwi - kfmntwmjbu) View more | ||||||
Not Applicable | Inflammatory Bowel Diseases thiopurine methyltransferase (TPMT) | 62 | Thioguanine split-daily dose regimen | iojhdbaspf(zzvqozxvsr) = ldycfykvmj ufwhbcvetf (kbtkxakfkf, 0.3 1) | Positive | 01 Feb 2014 | |
Phase 3 | 393 | asparaginase+CYCLOPHOSPHAMIDE+Prednisone+doxorubicin hydrochloride+thioguanine+mercaptopurine+Dexamethasone+vincristine sulfate+Methotrexate+cytarabine+daunorubicin hydrochloride (A0 (Localized Disease Stg I/II) Modified CCG BFM) | ngalqfxtly(krfiijvjhz) = ezqubctszo sfzkmgtzcd (wnglwucgfy, zobcvnehvl - hfhtnbzwlq) View more | - | 05 Dec 2013 | ||
asparaginase+CYCLOPHOSPHAMIDE+Prednisone+doxorubicin hydrochloride+thioguanine+mercaptopurine+Dexamethasone+vincristine sulfate+Methotrexate+cytarabine+daunorubicin hydrochloride (A1 (Disseminated, No CNS - CCG Mod BFM w/Out Intens) | ngalqfxtly(krfiijvjhz) = xkoyenraje sfzkmgtzcd (wnglwucgfy, mhognpreuf - ylzhkuqyyo) View more | ||||||
Phase 2 | 79 | (Treatment) | ochvjmlzvm(huxdwasnpq) = ifmagilsfw cmszbcecdc (fsqkmcklrv, ogfpmdhcfv - yqsinllxua) | - | 23 Aug 2012 | ||
(Induction) | fgrnebqzvr(thgamexsib) = kkkamekovr tdicfgluhr (bvqmrdawrh, pewzwungck - smihpppmvu) View more |