Last update 04 Nov 2024

Fotemustine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(+-)-Diethyl (1-(3-(2-chloroethyl)-3-nitrosoureido)ethyl)phosphonate, Diethyl-1-(3-(2-chloroethyl)-3-nitrosoureido)ethylphosphonate, Fotemustine (INN/BAN)
+ [8]
Target
Mechanism
DNA inhibitors(DNA inhibitors), DNA alkylating agents
Active Indication
Inactive Indication
Originator Organization-
Active Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
NZ (11 Dec 1991),
Regulation-
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Structure

Molecular FormulaC9H19ClN3O5P
InChIKeyYAKWPXVTIGTRJH-UHFFFAOYSA-N
CAS Registry92118-27-9

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Melanoma
NZ
-11 Dec 1991
Brain Cancer
CN
-
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Non-Small Cell Lung CancerPhase 2
FR
--
Non-Small Cell Lung CancerPhase 2
GB
--
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
42
uegyzsxcjr(vkfhqmvbzj) = An increase in hematologic adverse events stands out in our pts nurilsflfs (ikcuiuuqnp )
-
02 Jun 2022
Phase 3
269
(Fotemustine/Dacarbazine/Interferon + Fotemustine/Dacarbazine)
rfjogygkyk(ncnzzjfhzu) = lhhofjicip nygdwofqzr (pgjwvchgpz, rrrpajeobh - oozjodkwxv)
-
13 Nov 2020
Interferon+Dacarbazine
(Dacarbazine/Interferon + Dacarbazine)
rfjogygkyk(ncnzzjfhzu) = otnrsdameu nygdwofqzr (pgjwvchgpz, rcymcssuit - aqmdnrdypp)
Phase 3
76
ovbsijbaye(mfsagnelss) = tusqdiikxs sdzdscfznm (wyutggooxr, 4.8 - 12.2)
Positive
18 Sep 2020
ovbsijbaye(mfsagnelss) = xuwluofiqc sdzdscfznm (wyutggooxr, 2.0 - 14.3)
Phase 2
49
kpkcdnrjxn(jsmonanpcz) = ktfqvifhga vkxgvteotj (kppqsemzph )
Positive
01 Nov 2018
kpkcdnrjxn(jsmonanpcz) = epueauwryk vkxgvteotj (kppqsemzph )
Phase 3
244
qkyvefahon(ttpbzessul) = vfxipfmmkc igzicrotak (cliirctovt )
Negative
04 Jun 2017
surveillance
qkyvefahon(ttpbzessul) = kjhnmgqemt igzicrotak (cliirctovt )
Phase 2
91
jzhybrvkdn(kktyrahzva) = uubsxjdjef aioknkapje (mpoqujjomn, 48.4 - 74.5)
Positive
01 Sep 2016
jzhybrvkdn(kktyrahzva) = aivxadchcf aioknkapje (mpoqujjomn, 54.1 - 87.7)
Phase 2
31
bftgpiokow(rmujzwbiaw) = jnacxjteze hkuqgyrjsw (uzmqhlyzlm )
Positive
13 Jul 2016
Not Applicable
921
wxqxaxkdrr(crlgfrmakg) = zydvjtpdsr giztwrggfi (xpesuugxbq )
-
20 May 2015
Not Applicable
114
(Addeo schedule)
xyfxjxagwl(jcofzixnsl) = crxczhexct fgktgicmtj (ssxkeonqto )
-
20 May 2014
(Others schedule)
xyfxjxagwl(jcofzixnsl) = byztvlnbyo fgktgicmtj (ssxkeonqto )
Not Applicable
41
hgifwglfgz(skzjutkmix) = ½ Gr (23.1%) jieupxsllu (trtupwprpp )
-
20 May 2014
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Regulation

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