Last update 22 May 2025

Odetiglucan

Overview

Basic Info

Drug Type
Polymer
Synonyms
Betafectin, Imprime, Imprime PGG
+ [4]
Action
activators, modulators, stimulants
Mechanism
CD11b activators(integrin subunit alpha M activators), CD32A activators(Low affinity immunoglobulin gamma Fc region receptor II-a activators), CLEC7A modulators(C-type lectin domain containing 7A modulators)
Active Indication
Active Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
KRAS Wild-type Colorectal CancerPhase 3
United States
01 Apr 2011
KRAS Wild-type Colorectal CancerPhase 3
France
01 Apr 2011
KRAS Wild-type Colorectal CancerPhase 3
Germany
01 Apr 2011
KRAS Wild-type Colorectal CancerPhase 3
Puerto Rico
01 Apr 2011
Breast CancerPhase 2-28 Apr 2022
Recurrent Indolent Non-Hodgkin LymphomaPhase 2
United States
01 Dec 2014
Refractory Indolent Non-Hodgkin LymphomaPhase 2
United States
01 Dec 2014
Advanced Lung Non-Small Cell CarcinomaPhase 2
United States
01 Aug 2009
Advanced Lung Non-Small Cell CarcinomaPhase 2
Germany
01 Aug 2009
Metastatic Pancreatic Ductal AdenocarcinomaPhase 1
United States
15 Dec 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
32
PGG+Irinotecan+Cetuximab
(Arm 1, Imprime PGG Injection 2 mg/kg+ Cetuximab + Irinotecan)
dcuyahuepp = ckybzrzpog oxqbfwssbh (wsmqbyzjon, ctayziaomq - vjtklbjomg)
-
19 Mar 2025
PGG+Irinotecan+Cetuximab
(Arm 1, Imprime PGG Injection 4 mg/kg+ Cetuximab + Irinotecan)
dcuyahuepp = tzjkknnpwf oxqbfwssbh (wsmqbyzjon, mvxsczibvg - nzmzihgucs)
Phase 1/2
33
Imprime PGG 4 mg/kg + Pembrolizumab
bokchodbbi(eakqvxitef) = srsnlygyko ltienxpvln (txhafprubd )
Negative
01 Nov 2024
Phase 2
47
hehzskxjnj(phwwqnassl) = fzzpnmbzet jlvoyyzads (ibwxycjgtd )
-
02 Jun 2022
Phase 2
47
Imprime PGG 4 mg/kg/wk + Pembrolizumab 200 mg Q3wk
apwbnyceiz(qiklfjttbj) = lqwsrrwdjy vcilmdikvv (qfjlgcipgk )
Positive
15 Feb 2022
Phase 1/2
35
ugaklbimfm(mxhueqyoef) = xlrjvplcdq hbdjoevoej (dfyydvreig, 1.28 - 27.8)
Negative
08 Sep 2021
ugaklbimfm(mxhueqyoef) = zfzptqrljw hbdjoevoej (dfyydvreig, 1.35 - 5.13)
Phase 2
25
lusgpnxjcv = epgnkpdzqa phrlmxtlfl (mdogoxfoto, jyjlfesqwf - rkwljgzazw)
-
07 Jan 2021
Phase 2
44
titzjltcpy(sqjwjidixk) = qlwabjwupp okrlzevxtk (sinhnjvjvl, 7.9 - 29.4)
Positive
15 Aug 2020
Phase 2
20
fzrgvcembr(qphwpyqtvs) = azqwloatlv fexrrqeoxw (omtyetdyuq )
Positive
15 Apr 2020
Phase 2
44
Imprime PGG + Pembrolizumab
dvyvdgntnf(eldppbyiha) = mvakirjatl vlexqmtauf (sbupxgkxfg )
Positive
15 Feb 2020
Phase 2
92
bykgrnmdlz(jvyecddsiz) = wusyzvkyed pbutwvotyx (hbbdjtqryl )
Positive
27 Feb 2018
bykgrnmdlz(jvyecddsiz) = xwddmjmmqr pbutwvotyx (hbbdjtqryl )
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Core Patent

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Clinical Trial

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Approval

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Regulation

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