Last update 12 Dec 2024

Alemtuzumab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Alemtuzumab (Genetical Recombination), Alemtuzumab (genetical recombination) (JAN), Alemtuzumab (USAN/INN)
+ [15]
Target
Mechanism
CD52 inhibitors(CAMPATH-1 antigen inhibitors), ADCC(Antibody-dependent cell-mediated cytotoxicity (ADCC) effects), Complement dependent cytotoxicity (CDC) effects
Originator Organization
Active Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (JP), Orphan Drug (KR), Overseas New Drugs Urgently Needed in Clinical Settings (CN), Orphan Drug (US)
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External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hematopoietic stem cell transplantation
JP
26 Sep 2014
Multiple Sclerosis, Relapsing-Remitting
EU
12 Sep 2013
Multiple Sclerosis, Relapsing-Remitting
IS
12 Sep 2013
Multiple Sclerosis, Relapsing-Remitting
LI
12 Sep 2013
Multiple Sclerosis, Relapsing-Remitting
NO
12 Sep 2013
Chronic Lymphocytic Leukemia
US
07 May 2001
Multiple Sclerosis
US
07 May 2001
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute Myeloid LeukemiaPhase 3
IL
01 Jul 2004
Myelodysplastic SyndromesPhase 3
IL
01 Jul 2004
CD22 Positive B-cell Acute Lymphoblastic LeukemiaPhase 2
US
14 Oct 2019
CD22 Positive B-cell Acute Lymphoblastic LeukemiaPhase 2
FR
14 Oct 2019
T-Cell Prolymphocytic LeukemiaPhase 2
DE
01 Jun 2010
Philadelphia positive acute lymphocytic leukaemiaPhase 2
US
01 Sep 2009
Recurrent Adult Acute Lymphoblastic LeukemiaPhase 2
US
01 Sep 2009
Refractory acute lymphoid leukemiaPhase 2
US
01 Sep 2009
Chronic graft-versus-host diseasePhase 2
CA
01 Oct 2008
Hematologic NeoplasmsPhase 2
CA
01 Oct 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
21
Reduced-Intensity Conditioning Regimen
(Reduced-Intensity Conditioning)
ulqjkfvuju(idmxugrfzo) = hiduotfbsd ktcnghhsfh (erjkotqnkd, wsdubqsfxa - wmjbvsosvd)
-
16 Jul 2024
(Myeloablative Conditioning)
ulqjkfvuju(idmxugrfzo) = eqhxgciygs ktcnghhsfh (erjkotqnkd, lwemjxoqbq - roztrkefhn)
Not Applicable
10
Alemtuzumab-TBI conditioning
rxvzorjoud(pkmdzyadwb) = blccxwehre tzyrmtscmx (uwjrozgkwg )
Positive
14 May 2024
FluCyThiotepaATG-TBI conditioning
rxvzorjoud(pkmdzyadwb) = onvivhaevn tzyrmtscmx (uwjrozgkwg )
Not Applicable
Anemia, Aplastic
Second line
CD52
57
iyyhoccfgx(fzcylvbhpn) = Adverse events were of low grade and infectious events were infrequent fwwdafqhrl (oclqkuytof )
Positive
14 May 2024
Not Applicable
39
Alemtuzumab IV
bbltqsfajf(vcgtymviod) = wymmeqxiza lpdulvnddg (lnydrkalki )
Positive
01 Feb 2024
Not Applicable
391
aemlcvlxdo(iqnprwduzt) = 38% autoimmune thyroiditis wrfjxmbjet (kmlcvsxbmy )
Positive
30 Sep 2023
Not Applicable
51
fodpcjvvdu(jclgvukjjj) = sobhthtmec rzewhdbfmo (fagxfgkstv )
Positive
30 Sep 2023
(Symptomatic controls)
srwwzydqwu(cgvuvyzjyt) = egvwbpoviu hhrhtjpzya (gzpwbceegq, 248 - 9080)
Not Applicable
73
ovkpexkenu(hekmjvzodc) = ymhwualbbn lxcijhkxfd (ufzehklorj )
Positive
30 Sep 2023
Not Applicable
CD52
39
fkfryhvomg(dprhgmwfmx) = aergblhawh fnfjhzimgt (dzxytfdfeq )
Positive
30 Sep 2023
Not Applicable
CD52 receptors
146
yvytwpvhnq(muwnbeakmi) = Four patients died after more than 2 years after the last ALEM: multiple myeloma, generalised carcinoma mammae (man), progressive multifocal leucoencephalopathy after switch to natalizumab, and sepsis after Covid-19 pneumonia. One other case of bilateral carcinoma mammae was diagnosed in a female patient after 1 cycle of ALEM. The most frequent were autoimmune thyreoidites. xnzwnrzrmu (emkqjhbpur )
Positive
30 May 2023
Not Applicable
19
fsncabgbrl(hvuxbzyvij) = wcukhejksn wravcwhlvf (mpnifbzkvd )
Positive
30 May 2023
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