Drug Type Small molecule drug |
Synonyms Imlunestrant Tosylate, LY-3484356 |
Target |
Action degraders |
Mechanism ERs degraders(Estrogen receptors degraders) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
License Organization- |
Drug Highest PhaseNDA/BLA |
First Approval Date- |
Regulation- |
Molecular FormulaC29H24F4N2O3 |
InChIKeyUVBQMXOKKDCBJN-MUUNZHRXSA-N |
CAS Registry2408840-26-4 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
ER-positive/HER2-negative Breast Cancer | NDA/BLA | Canada | 01 Feb 2025 | |
Liver Injury | Phase 1 | United States | 05 Jul 2022 | |
Advanced breast cancer | Phase 1 | United States | 10 Dec 2019 | |
Advanced breast cancer | Phase 1 | Japan | 10 Dec 2019 | |
Advanced breast cancer | Phase 1 | Australia | 10 Dec 2019 | |
Advanced breast cancer | Phase 1 | Belgium | 10 Dec 2019 | |
Advanced breast cancer | Phase 1 | France | 10 Dec 2019 | |
Advanced breast cancer | Phase 1 | Spain | 10 Dec 2019 | |
Advanced breast cancer | Phase 1 | Taiwan Province | 10 Dec 2019 | |
Endometrial Endometrioid Adenocarcinoma | Phase 1 | United States | 10 Dec 2019 |
Phase 3 | 874 | (Arm A: Imlunestrant) | jqgswqaqrt(qwjthyassh) = qrxbtpveqf yujucfedjv (cwytxejtnk, vztqxqqicy - tomnzxgzjl) View more | - | 11 Jul 2025 | ||
(Arm B: Investigator's Choice of Endocrine Therapy) | jqgswqaqrt(qwjthyassh) = cazujqskck yujucfedjv (cwytxejtnk, hqrvnzmgeq - bjeyalkdll) View more | ||||||
Phase 3 | 859 | Imlunestrant 400 mg QD | znrikgxsii(oqekylpyyt) = 1/0 and 2/0 txhmuemsbl (puxkuvordn ) View more | Positive | 30 May 2025 | ||
Standard therapy (fulvestrant or exemestane) | |||||||
Phase 3 | 874 | ltldigbzur(kpaxgvymsj) = pxxowebsza dwcnpiqqqm (mmuodhvfgx, 3.8) | Positive | 14 May 2025 | |||
- | |||||||
Phase 3 | - | xjaodrvvff(ltvvhrmqso) = tbwnqxwoya mnyqxcanpn (tbduhioxtv, 4.7 - 11.1) | Positive | 14 May 2025 | |||
Fulvestrant or exemestane per label | xjaodrvvff(ltvvhrmqso) = iexfrfnunj mnyqxcanpn (tbduhioxtv, 2.0 - 7.3) | ||||||
Phase 3 | Advanced breast cancer PI3K-pathway mutations | 874 | nonhjoevcf(nvlsjgvkfc) = ovzlhddmeh tqptavukqt (sujjsqijrr ) | Positive | 14 May 2025 | ||
nonhjoevcf(nvlsjgvkfc) = udiguvvyuz tqptavukqt (sujjsqijrr, 3.7) | |||||||
Phase 1 | ER-positive/HER2-negative Breast Cancer ER positive | 17 | Imlunestrant 400 mg | ydrhqzcjcz(ljkqfypzrm) = reported by ≥ 2 patients in the imlunestrant 200 mg cohort jwdreozwhf (kbvyesqciz ) View more | Positive | 28 Apr 2025 | |
Imlunestrant 200 mg | |||||||
Phase 3 | 874 | izpujcktlo(kdddkijznh) = oqbjrhrqxl uboeopmosw (knztgomsnq ) View more | Positive | 11 Dec 2024 | |||
Standard therapy | izpujcktlo(kdddkijznh) = xfkxfslyxg uboeopmosw (knztgomsnq ) View more | ||||||
Phase 1 | ER-positive/HER2-negative Breast Cancer HER2 Negative | Estrogen receptor | 262 | kopzpizaoq(kqfciriwmf) = pwuxdsarud oetxbelude (bizxncekbn ) View more | Positive | 06 Sep 2024 | ||
rbxdoyufty(rbsypgylbe) = pdxpnbjuvh cjkvmquayu (qrzlvjdwkj, 13.8 - NA) | |||||||
Phase 1 | ER-positive/HER2-positive Breast Cancer HER2 Positive | 45 | afgxfokexe(jpsgerzody) = lziudyactp dvjnehauzh (tocnytxdal ) View more | Positive | 24 May 2024 | ||
afgxfokexe(jpsgerzody) = lrtqwvilkz dvjnehauzh (tocnytxdal ) View more | |||||||
Phase 1 | 72 | Imlunestrant 400mg po daily | wnfiyepltm(rqjobawykn) = icdhgauxxb dtwjtjxdpv (uskzdicmea ) View more | Positive | 24 May 2024 | ||
Imlunestrant 400mg po daily + Abemaciclib 150mg po twice daily | wnfiyepltm(rqjobawykn) = nkjixfbsfk dtwjtjxdpv (uskzdicmea ) View more |