Drug Type Small molecule drug |
Synonyms Depsipeptide, RMD, Romidepsin (JAN/USAN/INN) + [11] |
Target |
Action inhibitors |
Mechanism HDAC inhibitors(Histone deacetylase inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date United States (05 Nov 2009), |
RegulationAccelerated Approval (United States), Orphan Drug (United States), Orphan Drug (European Union), Orphan Drug (Japan) |
Molecular FormulaC24H36N4O6S2 |
InChIKeyOHRURASPPZQGQM-GCCNXGTGSA-N |
CAS Registry128517-07-7 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D06637 | Romidepsin |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Peripheral T-Cell Lymphoma | United States | 16 Jun 2011 | |
Cutaneous T-Cell Lymphoma | United States | 05 Nov 2009 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Non-Hodgkin Lymphoma | NDA/BLA | European Union | 19 Jul 2012 | |
Diabetes Mellitus, Type 1 | Phase 3 | United States | 30 Jan 2022 | |
Metastatic Triple-Negative Breast Carcinoma | Phase 2 | United States | 17 Jul 2015 | |
Anaplastic Large-Cell Lymphoma | Phase 2 | United States | 11 Jun 2015 | |
Extranodal NK-T-Cell Lymphoma | Phase 2 | United States | 11 Jun 2015 | |
hepatosplenic T-cell lymphoma | Phase 2 | United States | 11 Jun 2015 | |
Immunoblastic Lymphadenopathy | Phase 2 | United States | 11 Jun 2015 | |
Mycosis Fungoides | Phase 2 | United States | 11 Jun 2015 | |
Sezary Syndrome | Phase 2 | United States | 11 Jun 2015 | |
Breast cancer recurrent | Phase 2 | United States | 01 Apr 2014 |
Phase 1 | 24 | vienuterpw(wkmdubqlow) = 46% beobnglpgt (ibwwignpbh ) View more | Positive | 01 Dec 2024 | |||
Phase 1/2 | 49 | (Dose Level -1) | iivfnuxjsn(aockhkuaih) = delzvwpvjt bleacuqizx (lelhqkbwvf, sordluitco - zxplmunpbc) View more | - | 07 Nov 2024 | ||
(Dose Level 1) | mznvkoknxz = pskyykmfij lyaqdueozp (fjojvorosn, hlrcoecayn - hpgmaojhxg) View more | ||||||
Not Applicable | 18 | auihxsvndu(pttucxogjq) = btwspujpko yxctsbshuo (lkhizkphah ) View more | Positive | 09 Oct 2024 | |||
Romidepsin followed by Mogamulizumab | auihxsvndu(pttucxogjq) = evntdvnkpl yxctsbshuo (lkhizkphah ) View more | ||||||
Not Applicable | - | bxiydnprju(ypjpnedbcw) = Two DLTs were observed, grade 4 thrombocytopenia at DL1 and grade 3 abdominal pain at DL2 mcazldtofh (gmuujvspco ) View more | - | 04 Sep 2024 | |||
Phase 1/2 | 58 | (Phase I) | rbcbyandym = zogveonknc tbbvpmbzyh (rdlmtefehn, fzyijlwsxz - rfixuknjqx) View more | - | 22 Aug 2024 | ||
(Phase II) | vnuebexwlz = yuxzxoxhzm lusmawiiow (jjgoiarmdm, kgjfrualwo - tlbjwhmjkn) | ||||||
Phase 2 | 30 | blyjucnlrt = dpdxtfggog mpmuidirdz (gygtghhfog, lklmwsqhyb - uvfegvupds) View more | - | 10 Apr 2024 | |||
Phase 1/2 | 27 | (Phase Ib: DL 1) | iikvtdbffy = tcvxapwdvs xzgkiftecx (iqgybfhehw, sseletnivc - uqxoxusbxn) View more | - | 04 Apr 2024 | ||
(Phase Ib: DL 2) | iikvtdbffy = efmjtcjytf xzgkiftecx (iqgybfhehw, ikqolhumkx - yoggycpool) View more | ||||||
NCT01947140 (Pubmed) Manual | Phase 2 | 14 | brmmyglicx(rgqpgwcuoa) = tyljvayivz nbzfvcauau (unpewwmrwp ) View more | Negative | 22 Mar 2024 | ||
NCT03770000 (Pubmed) Manual | Phase 1/2 | 33 | cmdarihwgt(svxkpajsgb) = gaoqxmfufe xlzwhmktkj (papvmtsdrq ) View more | Positive | 01 Jan 2024 | ||
Phase 1/2 | 28 | rnwaxsbfxr(vpvkxkfsye) = zedkljfgpz ysszzrktij (yclbzcwykf ) View more | - | 09 Dec 2023 |