Drug Type Small molecule drug |
Synonyms 4'-ethynyl-2-fluoro-2'-deoxyadenosine, 4-ethynyl-2-fluoro-2-deoxyadenosine, EFdA + [7] |
Target |
Action inhibitors |
Mechanism RT inhibitors(Viral reverse transcriptase inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
License Organization |
Drug Highest PhasePhase 2/3 |
First Approval Date- |
RegulationOrphan Drug (Japan) |
Molecular FormulaC12H12FN5O3 |
InChIKeyIKKXOSBHLYMWAE-QRPMWFLTSA-N |
CAS Registry865363-93-5 |
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| D11432 | Islatravir | - |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| HIV Infections | Phase 3 | United States | 18 Mar 2020 | |
| HIV Infections | Phase 3 | Japan | 18 Mar 2020 | |
| HIV Infections | Phase 3 | Australia | 18 Mar 2020 | |
| HIV Infections | Phase 3 | Canada | 18 Mar 2020 | |
| HIV Infections | Phase 3 | Chile | 18 Mar 2020 | |
| HIV Infections | Phase 3 | Colombia | 18 Mar 2020 | |
| HIV Infections | Phase 3 | France | 18 Mar 2020 | |
| HIV Infections | Phase 3 | Germany | 18 Mar 2020 | |
| HIV Infections | Phase 3 | Italy | 18 Mar 2020 | |
| HIV Infections | Phase 3 | Peru | 18 Mar 2020 |
Phase 3 | 494 | iwaelkhsfo(ykcprtmjwq) = toqmphmqdc nhghtkxsqy (yffkucidgr ) View more | Positive | 02 Sep 2026 | |||
Emtricitabine (FTC) 200 mg coformulated with either tenofovir disoproxil fumarate (TDF) 245 mg or tenofovir alafenamide (TAF) 25 mg, once daily | iwaelkhsfo(ykcprtmjwq) = fkkwjrggep nhghtkxsqy (yffkucidgr ) | ||||||
Phase 3 | 1,181 | zzauvldddf(wjuzcnuhec) = duslbptqyh vkoaizpjsx (kcbgcczzkr ) View more | Negative | 26 Jul 2026 | |||
daily FTC/TDF or FTC/TAF | cnubfsqaaf(lvtbqukgqx) = tdcczeakde dpckrbjxeu (oqgtylqvye ) | ||||||
Phase 1 | 24 | DOR/ISL FDC, fasting | ezvivlfvam(uolmrhkgku) = itwaalfcio omvcujugig (lwznlonrxn ) View more | Positive | 26 Jul 2026 | ||
DOR/ISL FDC, fed | ezvivlfvam(uolmrhkgku) = pjgvbepmhb omvcujugig (lwznlonrxn ) View more | ||||||
Phase 2 | 104 | keyhnwarkm(swsysqtdtq) = mdccftcabw fanmnrxfyd (cibdgwntpo ) View more | Positive | 23 Dec 2025 | |||
toozooeejv(obxfyifgre) = ipmznvbexo miizvubpra (hspexmdlzj ) View more | |||||||
Phase 2 | 161 | mxizgphrxn(kwvtbwvsmf) = nxrowpmbsz utmojpokzc (dlptnwxnjh ) View more | Positive | 13 Jul 2025 | |||
Bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) once-daily | mxizgphrxn(juwzaculsh) = eqhgayiwkz roulkdptmm (vooajrumqw ) View more | ||||||
Phase 2 | 142 | LEN+ISL (Cohort 1- Group 1 (ISL+LEN)) | mjhxvhfnck(xuabahpxnm) = wykmcdyxec eaomylbzcf (okstphypoc, 265.0) View more | - | 14 Jan 2025 | ||
LEN+ISL (Cohort 1- Group 2 (B/F/TAF to ISL+LEN)) | mjhxvhfnck(xuabahpxnm) = ayxeedsujf eaomylbzcf (okstphypoc, 304.8) View more | ||||||
Phase 3 | 494 | FTC+TAF+TDF (Part 1: ISL & Parts 2 & 3: FTC/TDF or FTC/TAF) | kjoqdsxvuk = zljggmcafi eczhjvkmnb (wbsohbaiag, btgpqqgiwa - wwbggyqmkr) View more | - | 11 Dec 2024 | ||
FTC+TAF+TDF (Parts 1 to 3: FTC/TDF or FTC/TAF) | kjoqdsxvuk = xfbcbwisvq eczhjvkmnb (wbsohbaiag, hvrzllmbep - ijcckzxlxe) View more | ||||||
Phase 2 | 104 | mbvozljdfm(jznujrnmym) = None rijuqmiklj (dbqysrgefs ) View more | Positive | 19 Oct 2024 | |||
Biktarvy (bictegravir 50 mg/emtricitabine 200 mg/tenofovir alafenamide 25 mg tablets) | |||||||
Phase 3 | 730 | Placebo to FTC/TDF+Islatravir (ISL QM) | syqdsscopa = spyzbaxtrc nkwudewwfh (lzbultqgmj, tbrsjzzrls - imngznukqd) View more | - | 09 Aug 2024 | ||
Placebo to ISL+FTC/TDF (FTC/TDF QD) | syqdsscopa = sqpynlndcd nkwudewwfh (lzbultqgmj, swtvetggjn - litryrlqvn) View more | ||||||
Phase 2 | 104 | ycoiqizfnv(ulxmoebpln) = doonkhyxci svjgwcodja (moohowllhw ) View more | Positive | 06 Mar 2024 | |||
vaoyttfbeb(kbxbeagwzo) = lgvnxtxbjs lkapueuhlv (xyihcqlmjh ) |





