Last update 21 Oct 2026

Islatravir

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
4'-ethynyl-2-fluoro-2'-deoxyadenosine, 4-ethynyl-2-fluoro-2-deoxyadenosine, EFdA
+ [7]
Target
Action
inhibitors
Mechanism
RT inhibitors(Viral reverse transcriptase inhibitors)
Active Indication
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 2/3
First Approval Date-
RegulationOrphan Drug (Japan)
Login to view timeline

Structure/Sequence

Molecular FormulaC12H12FN5O3
InChIKeyIKKXOSBHLYMWAE-QRPMWFLTSA-N
CAS Registry865363-93-5

External Link

KEGGWikiATCDrug Bank
D11432Islatravir-

R&D Status

10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
HIV InfectionsPhase 3
United States
18 Mar 2020
HIV InfectionsPhase 3
Japan
18 Mar 2020
HIV InfectionsPhase 3
Australia
18 Mar 2020
HIV InfectionsPhase 3
Canada
18 Mar 2020
HIV InfectionsPhase 3
Chile
18 Mar 2020
HIV InfectionsPhase 3
Colombia
18 Mar 2020
HIV InfectionsPhase 3
France
18 Mar 2020
HIV InfectionsPhase 3
Germany
18 Mar 2020
HIV InfectionsPhase 3
Italy
18 Mar 2020
HIV InfectionsPhase 3
Peru
18 Mar 2020
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
494
iwaelkhsfo(ykcprtmjwq) = toqmphmqdc nhghtkxsqy (yffkucidgr )
Positive
02 Sep 2026
Emtricitabine (FTC) 200 mg coformulated with either tenofovir disoproxil fumarate (TDF) 245 mg or tenofovir alafenamide (TAF) 25 mg, once daily
iwaelkhsfo(ykcprtmjwq) = fkkwjrggep nhghtkxsqy (yffkucidgr )
Phase 3
1,181
zzauvldddf(wjuzcnuhec) = duslbptqyh vkoaizpjsx (kcbgcczzkr )
Negative
26 Jul 2026
daily FTC/TDF or FTC/TAF
cnubfsqaaf(lvtbqukgqx) = tdcczeakde dpckrbjxeu (oqgtylqvye )
Phase 1
24
DOR/ISL FDC, fasting
ezvivlfvam(uolmrhkgku) = itwaalfcio omvcujugig (lwznlonrxn )
Positive
26 Jul 2026
DOR/ISL FDC, fed
ezvivlfvam(uolmrhkgku) = pjgvbepmhb omvcujugig (lwznlonrxn )
Phase 2
104
keyhnwarkm(swsysqtdtq) = mdccftcabw fanmnrxfyd (cibdgwntpo )
Positive
23 Dec 2025
toozooeejv(obxfyifgre) = ipmznvbexo miizvubpra (hspexmdlzj )
Phase 2
161
mxizgphrxn(kwvtbwvsmf) = nxrowpmbsz utmojpokzc (dlptnwxnjh )
Positive
13 Jul 2025
Bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) once-daily
mxizgphrxn(juwzaculsh) = eqhgayiwkz roulkdptmm (vooajrumqw )
Phase 2
142
LEN+ISL
(Cohort 1- Group 1 (ISL+LEN))
mjhxvhfnck(xuabahpxnm) = wykmcdyxec eaomylbzcf (okstphypoc, 265.0)
-
14 Jan 2025
LEN+ISL
(Cohort 1- Group 2 (B/F/TAF to ISL+LEN))
mjhxvhfnck(xuabahpxnm) = ayxeedsujf eaomylbzcf (okstphypoc, 304.8)
Phase 3
494
FTC+TAF+TDF
(Part 1: ISL & Parts 2 & 3: FTC/TDF or FTC/TAF)
kjoqdsxvuk = zljggmcafi eczhjvkmnb (wbsohbaiag, btgpqqgiwa - wwbggyqmkr)
-
11 Dec 2024
FTC+TAF+TDF
(Parts 1 to 3: FTC/TDF or FTC/TAF)
kjoqdsxvuk = xfbcbwisvq eczhjvkmnb (wbsohbaiag, hvrzllmbep - ijcckzxlxe)
Phase 2
104
Islatravir 2 mg + Lenacapavir 300 mg once a week
mbvozljdfm(jznujrnmym) = None rijuqmiklj (dbqysrgefs )
Positive
19 Oct 2024
Biktarvy (bictegravir 50 mg/emtricitabine 200 mg/tenofovir alafenamide 25 mg tablets)
Phase 3
730
Placebo to FTC/TDF+Islatravir
(ISL QM)
syqdsscopa = spyzbaxtrc nkwudewwfh (lzbultqgmj, tbrsjzzrls - imngznukqd)
-
09 Aug 2024
Placebo to ISL+FTC/TDF
(FTC/TDF QD)
syqdsscopa = sqpynlndcd nkwudewwfh (lzbultqgmj, swtvetggjn - litryrlqvn)
Phase 2
104
ycoiqizfnv(ulxmoebpln) = doonkhyxci svjgwcodja (moohowllhw )
Positive
06 Mar 2024
vaoyttfbeb(kbxbeagwzo) = lgvnxtxbjs lkapueuhlv (xyihcqlmjh )
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Hiro LS Researcher
The AI Search Engine Built to Accelerate Biopharma Decisions
Search across billion-scale life sciences data to uncover signals, validate evidence, and act with confidence.
Ask any biopharma research question→
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, Patsnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Discover Synapse Data Servers
Synapse data is now integrated into the PatSnap LS Model Context Protocol (MCP) service. Customize your LLM agent now using our MCP server!
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free