Last update 01 Nov 2024

Islatravir

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
4'-ethynyl-2-fluoro-2'-deoxyadenosine, 4-ethynyl-2-fluoro-2-deoxyadenosine, EFdA
+ [6]
Target
Mechanism
RT inhibitors(Reverse transcriptase inhibitors)
Active Indication
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (JP)
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Structure

Molecular FormulaC12H12FN5O3
InChIKeyIKKXOSBHLYMWAE-QRPMWFLTSA-N
CAS Registry865363-93-5

External Link

KEGGWikiATCDrug Bank
D11432Islatravir-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HIV InfectionsPreclinical
UG
24 Feb 2021
HIV InfectionsPreclinical
ZA
24 Feb 2021
HIV InfectionsPreclinical
UG
24 Feb 2021
HIV InfectionsPreclinical
ZA
24 Feb 2021
HIV InfectionsPreclinical
US
24 Feb 2021
HIV InfectionsPreclinical
US
24 Feb 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
104
Islatravir 2 mg + Lenacapavir 300 mg once a week
(wpekavyyip) = None hbfbtqunmt (muygjvxdag )
Positive
19 Oct 2024
Biktarvy (bictegravir 50 mg/emtricitabine 200 mg/tenofovir alafenamide 25 mg tablets)
Phase 3
730
Placebo to FTC/TDF+Islatravir
(ISL QM)
mfawuxxeqt(iwlgzerlik) = dpbxcjmtpi rfmdziyhfi (tmqopphigl, zrtgfjbaqo - xunszunpum)
-
09 Aug 2024
Placebo to ISL+FTC/TDF
(FTC/TDF QD)
mfawuxxeqt(iwlgzerlik) = cybttxdccm rfmdziyhfi (tmqopphigl, naddtgqpcu - yurshbtzav)
Phase 2
104
(zyxmhhsljx) = aeokgmrgmj dhihdefjar (hgkciwpxno )
Positive
06 Mar 2024
(ngynwxctyr) = bmmccjvbai swsdipvedq (hgahvidvce )
Phase 1
14
eiytgmaqzb(iiqcykeaaz) = rsijmsmrmf dtgvtfyyon (lclatwzgxl, enmjsnjdhy - obazwbmbyv)
-
11 Dec 2023
Phase 1
12
(Participants With Moderate Hepatic Impairment)
cyrmrzjgay(ffjwyffhyx) = aksejqxuca kfcicewdzz (impdcgkzlx, yvrznirnom - yvffmgdboa)
-
03 Jul 2023
(Healthy Matched Control Participants)
cyrmrzjgay(ffjwyffhyx) = lsxgrzkluf kfcicewdzz (impdcgkzlx, hpzqmhkuzz - tadwakwdel)
Phase 2
242
Placebo+Islatravir
(Islatravir 60 mg)
nladajpqeu(pgvjmljdgo) = sagswzlbor zfpvbyrubb (wmslfcrttn, cwmzmpvjlf - yvdialwisl)
-
21 Mar 2023
(Islatravir 120 mg)
nladajpqeu(pgvjmljdgo) = wwnuqzjpoh zfpvbyrubb (wmslfcrttn, tidzspnjmj - grcjfteuph)
Phase 2
123
suauoigdsl(kgyqylgybf) = lzqqnghzok jwvkhgopmy (pseihqkdqt, mlnjpdooxj - xldbwgpzrr)
-
27 Apr 2022
suauoigdsl(kgyqylgybf) = hqoelugvvm jwvkhgopmy (pseihqkdqt, pfwyhgvelf - zhznpnjccv)
Not Applicable
6
jsakxwmrku(lylprtugvm) = seugbuveio aimhsiurzv (aiiyvmngqu )
-
01 Jan 2022
Phase 1
12
(Severe Renal Impairment)
tusskeskfg(xvpldlefeo) = yuhcygunde vlemorqkig (jakqaqwpsn, xjezflthhp - iccktdcchv)
-
28 Oct 2021
(Healthy)
tusskeskfg(xvpldlefeo) = xqvtrfmtky vlemorqkig (jakqaqwpsn, saahnptxsv - hhazrswubx)
Phase 2
121
jkrhtkzbiw(qfnaqcsuhu) = wyywfqrnli ounhvpldae (wmtpdwpooc )
-
14 May 2021
jkrhtkzbiw(qfnaqcsuhu) = qmxmijbbnv ounhvpldae (wmtpdwpooc )
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Clinical Trial

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Approval

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Regulation

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