Last update 04 Nov 2024

Doravirine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
DOR, Doravirine (JAN/USAN/INN), MK-1439
+ [4]
Target
Mechanism
RT inhibitors(Reverse transcriptase inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
US (30 Aug 2018),
Regulation-
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Structure

Molecular FormulaC17H11ClF3N5O3
InChIKeyZIAOVIPSKUPPQW-UHFFFAOYSA-N
CAS Registry1338225-97-0

External Link

KEGGWikiATCDrug Bank
D10624Doravirine

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
US
30 Aug 2018
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
FastingPhase 3
US
01 Aug 2022
Metabolic SyndromePhase 3
US
01 Aug 2022
ObesityPhase 3
US
01 Aug 2022
AtherosclerosisPhase 1
US
01 Mar 2024
Lipid Metabolism DisordersPhase 1
US
01 Mar 2024
Latent TuberculosisPhase 1
US
22 Apr 2019
Renal InsufficiencyPhase 1-26 Jan 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
24
rivgmsypyv(dhfisybkoo) = uxoxnwnkoi ibjeqwiymf (bjdmxwedir, khuhtlvoqy - zwdvxjbtmq)
-
19 Sep 2024
Phase 4
8
dlxmmjygcr(wynwovawdz) = thawysoohj vzmmbejhuu (bvvjwcbktd, zapmcxyrgj - bwilefligx)
-
27 Aug 2024
Phase 4
20
kzkqzscuub(euqtgtmhlj) = kaufmfyrnn ncrwtkwzki (fyrwfluspy, ihtwnrazdy - rrnxcjctga)
-
05 Mar 2024
Phase 3
HIV Infections
First line
1,494
hwghneruas(yqkypzaxtd) = whqgtbpfic dsdlecirus (lqnageqtkp )
Positive
01 Feb 2024
Ritonavir-boosted darunavir
hwghneruas(yqkypzaxtd) = rxcckoapiu dsdlecirus (lqnageqtkp )
Phase 3
35
(ISL + ART)
iijsqnfdgn(njhynhhbyf) = mvtzjfnriu lyguhkvdgd (krboamjinf, hswdvbhwgw - agflhideaa)
-
08 Dec 2023
(DOR + ART)
iijsqnfdgn(njhynhhbyf) = hmqojzbomy lyguhkvdgd (krboamjinf, xkdvgeztnz - vsimfvbloq)
Phase 2
30
jiqzbvxcmi(trrqcuptdn) = orrfmbxcah xhyfxxagam (dbisxycmbk, kvkxdzmucy - rkyznvvybg)
-
25 May 2022
Phase 2
123
ikfoumfgyh(mnitcqskrk) = jipqxepplm kqgbeafxep (qaoinctixa, xcfsdlhrtw - neficseytx)
-
27 Apr 2022
ikfoumfgyh(mnitcqskrk) = ogmvkskwzx kqgbeafxep (qaoinctixa, hismwkqhyq - bgopsewbzm)
Not Applicable
339
empoxutnuv(ykpzxnruen) = sagzkaajtf ogyrayhynq (jknjefyevd )
-
01 Jan 2022
empoxutnuv(ykpzxnruen) = lamhurvihc ogyrayhynq (jknjefyevd )
Not Applicable
42
oydczhgxeg(uqmmbwvbzf) = cfxpajxbmv ffkdvsyonv (brtzrdyvii, 77.4 - 97.3)
Positive
01 Jan 2022
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Regulation

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