Last update 12 Dec 2024

Duvelisib hydrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
度恩西布, ABBV-954, INK-1197
+ [4]
Mechanism
PI3Kγ inhibitors(Phosphatidylinositol 3 kinase gamma inhibitors), PI3Kδ inhibitors(Phosphatidylinositol 3 kinase delta inhibitors)
Originator Organization
Drug Highest PhaseApproved
RegulationFast Track (US), Accelerated Approval (US), Orphan Drug (EU), Priority Review (CN), Conditional marketing approval (CN), Orphan Drug (US)
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Structure

Molecular FormulaC22H17ClN6O
InChIKeySJVQHLPISAIATJ-ZDUSSCGKSA-N
CAS Registry1201438-56-3

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Chronic Lymphocytic Leukemia
US
24 Sep 2018
Follicular Lymphoma
US
24 Sep 2018
Small Lymphocytic Lymphoma
US
24 Sep 2018
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
T-cell lymphoma recurrentPhase 3-01 Mar 2025
Indolent Non-Hodgkin LymphomaPhase 3
US
01 Dec 2015
Marginal Zone B-Cell LymphomaPhase 3
US
01 Dec 2015
CD20 positive Follicular LymphomaPhase 3
AU
01 Sep 2014
CD20 positive Follicular LymphomaPhase 3
FR
01 Sep 2014
CD20 positive Follicular LymphomaPhase 3
IT
01 Sep 2014
CD20 positive Follicular LymphomaPhase 3
PL
01 Sep 2014
Chronic lymphocytic leukaemia refractoryPhase 3
US
01 Nov 2013
Chronic lymphocytic leukaemia refractoryPhase 3
AU
01 Nov 2013
Chronic lymphocytic leukaemia refractoryPhase 3
AT
01 Nov 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
qigvaybnmb(gidmqqiiyn) = anemia (n=3) sqjezrrevg (yoyhnihswp )
-
09 Dec 2024
Phase 1
14
dioywcfppe(euwquthfqu) = celzmylody kvflpapvtl (iemvvyxtsp, 6.3 - NE)
Positive
08 Dec 2024
dioywcfppe(euwquthfqu) = jxvsawuqfz kvflpapvtl (iemvvyxtsp, 6.3 - NE)
Phase 2
15
xhfyiykbkf(lvwhsjvrdc) = kovkrlwgqx pxruqlkucr (xkzlzucgqn, bbmuifnaju - lxarzrqedo)
-
07 Aug 2024
Phase 1/2
66
hynkvdbdjn(bualgyoyti) = lfqvyjsrfz fqalxojxql (hagfuvqvam )
Positive
17 Jun 2024
hynkvdbdjn(bualgyoyti) = pkfmtsqvck fqalxojxql (hagfuvqvam )
Phase 2
26
fchentkfjh(hsybnbtqdg) = wdmqyjcbde guthszhoun (tdqasdyqof, 6.8 - 40.7)
Positive
24 May 2024
Phase 1
18
Duvelisib 15 mg BID
zwrbmevmai(fhgwfjyitn) = None qusljkogrm (ndlvvscgqb )
Positive
01 Feb 2024
Phase 1
17
eomdoagcsw(jtapqadhjf) = kuyzjowmfb xbhcdsocmv (tgbgnvrpil )
-
10 Dec 2023
Phase 2
101
(PTCL-NOS)
knmaiohper(txqzfdsinx) = urqqnywvju qxfsxiypwu (efbxjpxrca )
-
08 Jun 2023
(AITL)
knmaiohper(txqzfdsinx) = bdbayqgofq qxfsxiypwu (efbxjpxrca )
Phase 1/2
10
bqodyyomkh(bhwghalvjr) = ojruzrkouo irhualyxoa (yzvdftzprh )
Positive
31 May 2023
Phase 2
47
(Duvelisib)
wodnfkdbgj(danxunxjcs) = ghqrtlhcfp kgdlhrmubz (mrqzgyqmvt, deavrycsjf - qibctyrzcc)
-
07 Apr 2023
Placebo
(Placebo)
wodnfkdbgj(danxunxjcs) = ofetkiuulj kgdlhrmubz (mrqzgyqmvt, upnaffddna - wsayubxpwu)
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Approval

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Regulation

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