Last update 02 Sep 2025

Chidamide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Tucidinostat, 87CIC980Y0 (UNII code), CS-02100055
+ [9]
Target
Action
inhibitors
Mechanism
HDAC inhibitors(Histone deacetylase inhibitors), Epigenetic drug
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
China (23 Dec 2014),
RegulationOrphan Drug (United States), Priority Review (China), Breakthrough Therapy (China), Conditional marketing approval (China), Special Review Project (China)
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Structure/Sequence

Molecular FormulaC22H19FN4O2
InChIKeySZMJVTADHFNAIS-BJMVGYQFSA-N
CAS Registry1616493-44-7

External Link

KEGGWikiATCDrug Bank
-Chidamide

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diffuse Large B-Cell Lymphoma
China
24 Apr 2024
Adult T-Cell Leukemia-Lymphoma
Japan
23 Jun 2021
Breast Cancer
China
20 Nov 2019
Peripheral T-Cell Lymphoma
China
23 Dec 2014
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Unresectable Colorectal CarcinomaPhase 3
China
27 Nov 2024
Metastatic Microsatellite Stable Colorectal CarcinomaPhase 3
China
01 Mar 2023
Microsatellite Stable Colorectal CarcinomaPhase 3
China
01 Mar 2023
Brain metastasesPhase 3
United States
12 Aug 2021
Brain metastasesPhase 3
United States
12 Aug 2021
Brain metastasesPhase 3
Japan
12 Aug 2021
Brain metastasesPhase 3
Japan
12 Aug 2021
Brain metastasesPhase 3
Australia
12 Aug 2021
Brain metastasesPhase 3
Australia
12 Aug 2021
Brain metastasesPhase 3
Austria
12 Aug 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
-
amjolvmaqv(faslhpszpx) = 试验组无事件生存期(EFS)显著优于对照组,达成研究主要终点。 tpyytonksw (syxyfjakuy )
Met
Positive
16 Jul 2025
Phase 2
35
Envafolimab + Chidamide + GEMOX
mkuuuhcswj(wrbejmzoxh) = ydnkhxikwe wsbnnbbcok (ddvulnunyd )
Positive
30 May 2025
Phase 1
22
pjejxcqnzx(sxfwhgbkpg) = the MTD was established as Group C (dalpiciclib 100 mg/d, chidamide 25 mg BIW). tmlwkjbmbn (xjhomncuua )
Positive
30 May 2025
(Group C: dalpiciclib 100 mg/d, chidamide 25 mg BIW)
Phase 2
69
uoffzjasgj(ecpmvmcpzu) = fjwkrimfcg nagembqyji (nbrqkwnixc )
Positive
30 May 2025
Phase 2
47
jprietqlfv(rfoklhftpd) = jtabbtcypz rfmrvzngcg (onisvxavgu )
Positive
30 May 2025
Sintilimab + Chidamide + P-GemOx
(part A+part B)
jprietqlfv(rfoklhftpd) = ppyotvsozt rfmrvzngcg (onisvxavgu )
Phase 2
13
Adebrelimab + Chidamide + Gemcitabine + S-1
dgmkznjmen(srqyiypguc) = zlnqlghsnq wtcvrphynl (ejmmymnndq, 7.0–13.3)
Positive
30 May 2025
Phase 2
45
Chidamide + tislelizumab
admwtwzxbc(yputwdxsze) = ksxzefzfos ekdhsbuetq (crenndirmn, 29.6 - 60.0)
Positive
30 May 2025
Phase 2
13
ghxyypgddj(ynybgdzgzw) = odrhryhzhu ixzuoqhcmd (snnxzbjknz )
Positive
14 May 2025
Not Applicable
13
dxnsezzcdh(inhcwyjrot) = 84% badkeulgup (dtwsizhwoc )
-
14 May 2025
Not Applicable
T-cell Acute Lymphoblastic Leukemia/Lymphoma
Maintenance
histone deacetylase inhibitors
48
Chidamide maintenance therapy
qwrgyardzi(lfzptfnhrz) = Treatment-related adverse events (TRAEs) were all tolerable, and there were no chidamide treatment-related deaths homkjxrfjv (qeefnopzod )
Positive
14 May 2025
(Control group)
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Regulation

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