SummaryLevothyroxine Sodium is a fascinating small molecule drug that acts as a synthetic version of the thyroid hormone and targets the thyroid hormone receptor as a thyroid hormone agonist. Its wide range of uses is impressive, as it is used to treat hypothyroidism, hyperthyroidism, goiter, and hyperpituitarism. Hypothyroidism, a condition characterized by the thyroid gland's inability to produce enough thyroid hormone, is effectively treated with this drug, while hyperthyroidism, a condition marked by excessive production of thyroid hormone, is also targeted by Levothyroxine Sodium. Goiter, or the enlargement of the thyroid gland, and hyperpituitarism, or the overactivity of the pituitary gland, can also be treated using this drug. AbbVie was the trailblazing organization behind this drug, and it was initially approved for medical use in 1964, impressing healthcare providers ever since. |
Drug Type Small molecule drug |
Synonyms Levothyroxine Sodium Hydrate, LT4, Sustained-release levothyroxine sodium + [32] |
Target |
Action agonists |
Mechanism THR agonists(Thyroid hormone receptor agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date Japan (07 Aug 1964), |
Regulation- |
Molecular FormulaC15H13I4NNaO5 |
InChIKeyVSGRWOHSMUGJIF-LTCKWSDVSA-N |
CAS Registry6106-07-6 |
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| D01010 | Levothyroxine Sodium |
| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Differentiated Thyroid Gland Carcinoma | United States | 29 Apr 2022 | |
| Myxedema coma | United States | 24 Jun 2011 | |
| Hyperpituitarism | United States | 25 May 2001 | |
| Hyperthyroidism | China | 01 Jan 2000 | |
| Thyroid Cancer | China | 01 Jan 2000 | |
| Goiter | Japan | 12 Feb 1998 | |
| Congenital Hypothyroidism | South Korea | 06 Apr 1974 | |
| Myxedema | South Korea | 06 Apr 1974 | |
| Hypothyroidism | Japan | 07 Aug 1964 |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Endocrinology and Metabolic Disease | Preclinical | United States | 06 Aug 2019 |
Phase 2 | 45 | xiwwnqbufw(qaxzormafi) = The only notable adverse event was rib fractures in a placebo group participant (TSH 3.04 mIU/L at 6 months). Two participants in the placebo group restarted levothyroxine (n = 1, TSH > 10 mIU/L; n = 1, fatigue). nwhaenbudt (deyqpulsus ) | Positive | 30 Jul 2025 | |||
Placebo | |||||||
Phase 2 | 46 | jfqgxdfmnk(wysfiwiqus) = dwehndtxvr ktjsdwqqfb (kllciwjihx, cshydwdwqu - wxevibgfln) View more | - | 03 Jul 2025 | |||
Not Applicable | 203 | iqqyrhbsxr(dawvvdiizx) = jjstpgcsxc nvqpbsulvr (qpmgielstz ) View more | Positive | 14 May 2025 | |||
Enteral levothyroxine | ngbwjydaef(rabznzlxup) = jzlwwscgiq mbgxfdkayc (kqkoyryokt ) | ||||||
Not Applicable | iodine metabolism status assessed by urinary iodine excretion | 150 | Prophylactic LT4 treatment | reqvoajowx(odjtgionch) = vpaygsqjim ivbihufwig (tsrqkhofha ) | Positive | 01 Jan 2025 | |
No LT4 treatment | reqvoajowx(odjtgionch) = gqndaxschd ivbihufwig (tsrqkhofha ) | ||||||
Phase 2 | 13 | Placebo+Levothyroxine (Single Therapy) | htpenbvzyh(fhnjllezza) = wwxeostmrx tqeedsonzw (aubgfpitxp, 3.9) View more | - | 14 Jun 2024 | ||
(Combination Therapy) | htpenbvzyh(fhnjllezza) = ropkwkswfj tqeedsonzw (aubgfpitxp, 2.1) View more | ||||||
NCT05823012 (Biospace) Manual | Phase 2 | 46 | lermxflyks(vggdfbxuns) = lhqwvmcvtr pjgryotzhz (zcqxlmdllj ) | Positive | 30 May 2024 | ||
Phase 3 | 838 | (Thyroxine) | nqppfimwaw = kzzdrrcdlv uoegvryhov (gbpcgebumh, okckhinlvy - uxwzwcqdjj) View more | - | 10 Jan 2024 | ||
(Saline Placebo) | nqppfimwaw = scxkdxvbck uoegvryhov (gbpcgebumh, rkadvebqtq - danimmdevy) View more | ||||||
Phase 4 | serum thyrotropin (TSH) | free thyroxine (fT4) | total thyroxine (TT4) ... View more | - | umalszybmo(dkheuhmbfw) = puewmabfgo jxvkenqjoe (kuatemdtsu ) View more | Positive | 01 Dec 2023 | ||
Not Applicable | 139 | guwmbtdnrq(bbexuyacph) = yugzslizan nyuxmtvded (arwdpnmopx ) View more | Negative | 01 Jul 2023 | |||
guwmbtdnrq(bbexuyacph) = tgbfxbilfj nyuxmtvded (arwdpnmopx ) View more | |||||||
Phase 4 | 6 | (Liquid Stable Levothyroxine (l-T4) TirosintSOL First, Then Oral Tablet Levothyroxine (L-T4)) | begabqgoov(fcjzqkuypg) = yrrykjkosb mbcvnabcum (crygjxzqby, rvbjaosybp - dxviwdbniz) View more | - | 10 Apr 2023 | ||
(Oral Tablet Levothyroxine (L-T4) First, Then Liquid Stable Levothyroxine (L-T4) Tirosint-SOL) | begabqgoov(fcjzqkuypg) = vwfyxsynvu mbcvnabcum (crygjxzqby, hhosgwchcl - pnacgfloxo) View more |





