Last update 08 May 2025

Bicalutamide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Bicalutamide (JAN/USP/INN), Pencial
+ [11]
Target
Action
antagonists
Mechanism
AR antagonists(Androgen Receptor antagonists)
Originator Organization
Inactive Organization-
License Organization
Drug Highest PhaseApproved
First Approval Date
United Kingdom (23 Feb 1995),
RegulationAccelerated Approval (United States)
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Structure/Sequence

Molecular FormulaC18H14F4N2O4S
InChIKeyLKJPYSCBVHEWIU-UHFFFAOYSA-N
CAS Registry90357-06-5

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Metastatic Prostate Carcinoma
United States
04 Oct 1995
Prostatic Cancer
United Kingdom
23 Feb 1995
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Familial TestotoxicosisPhase 2
United Kingdom
22 Nov 2004
Familial TestotoxicosisPhase 2
United States
22 Nov 2004
Familial TestotoxicosisPhase 2
India
22 Nov 2004
Familial TestotoxicosisPhase 2
Canada
22 Nov 2004
Familial TestotoxicosisPhase 2
France
22 Nov 2004
GynecomastiaPhase 2
Italy
01 Dec 2003
MastodyniaPhase 2-01 Nov 2002
Non-metastatic prostate cancerPhase 2
Canada
01 Aug 1995
Non-metastatic prostate cancerPhase 2
United States
01 Aug 1995
Advanced Prostate CarcinomaPhase 2
United States
01 Dec 1994
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
-
(avzhtfmjhd) = gepjdtthtd qwebyknhvr (xowqtohsav, 7.4 - 16.6)
Superior
18 Dec 2024
(avzhtfmjhd) = kvwnmvlmou qwebyknhvr (xowqtohsav, 5.5 - 8.3)
Phase 3
Hormone-dependent prostate cancer
prostate-specific antigen
654
Rezvilutamide plus ADT
(uuagbsryey) = mcppapftic wjrknhhomp (cqmxevtksc )
Positive
01 Oct 2024
Bicalutamide plus ADT
(uuagbsryey) = oyuuumzfek wjrknhhomp (cqmxevtksc )
Phase 2
Metastatic breast cancer
AR+ | hormone positive | ER Negative ...
29
(hwfkmtaiit) = uaainrllle jzlrujcfdu (nypueacnbu )
Negative
16 Sep 2024
(hwfkmtaiit) = eubcouskmn jzlrujcfdu (nypueacnbu )
ESMO2024
ManualManual
Not Applicable
20
(qlxdcodhzq) = pxvpjawlld aanivstxdz (fldegghmhk, 0.5 - 62.5)
Positive
14 Sep 2024
Not Applicable
-
gsmpvrlqsz(gpceaajytt) = pH 7.42, PCO2 32, and PO2 66 igutjhubok (ypbrihvtjh )
-
19 May 2024
AUA2024
ManualManual
Phase 2
28
(qzhwkhtwrb) = Patients with higher serum levels of ErbB3 exhibited a better response to the bicalutamide+RAD001 treatment nmfuhbsnjk (axhtoisfer )
Positive
01 May 2024
Bicalutamide+RAD001(low serum ErbB3)
Phase 2
345
(rxwowdwuqi) = chuhgwynup yieqmqbwtg (bntaxlkcap )
Positive
25 Jan 2024
(rxwowdwuqi) = eeaunhagsc yieqmqbwtg (bntaxlkcap )
Phase 3
760
(eomtvmaute) = iaomxyzbct zgppkpslcb (dhvcrmpcic, 47 - 58)
Positive
25 Jan 2024
RT + placebo
(eomtvmaute) = fsqoookhvd zgppkpslcb (dhvcrmpcic, 38 - 48)
Not Applicable
-
(fohtdfxbkc) = ixhpacekye oiikwpsxsa (nqetfniity )
-
25 Jan 2024
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Regulation

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