Last update 07 Jun 2025

Evorpacept

Overview

Basic Info

Drug Type
Fc fusion protein
Synonyms
CD47/SIRPa-blocking Agent ALX 148, SIRPa Variant ALX 148, ALX 148
+ [2]
Target
Action
inhibitors
Mechanism
CD47 inhibitors(Cluster of differentiation 47 inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhasePhase 2/3
First Approval Date-
RegulationFast Track (United States), Orphan Drug (United States), Orphan Drug (European Union)
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Structure/Sequence

External Link

KEGGWikiATCDrug Bank
D12193---

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HER2-expressing Gastric AdenocarcinomaPhase 3
United States
15 Jan 2022
HER2-expressing Gastric AdenocarcinomaPhase 3
United States
15 Jan 2022
HER2-expressing Gastric AdenocarcinomaPhase 3
Japan
15 Jan 2022
HER2-expressing Gastric AdenocarcinomaPhase 3
Japan
15 Jan 2022
HER2-expressing Gastric AdenocarcinomaPhase 3
Australia
15 Jan 2022
HER2-expressing Gastric AdenocarcinomaPhase 3
Australia
15 Jan 2022
HER2-expressing Gastric AdenocarcinomaPhase 3
Belgium
15 Jan 2022
HER2-expressing Gastric AdenocarcinomaPhase 3
Belgium
15 Jan 2022
HER2-expressing Gastric AdenocarcinomaPhase 3
Czechia
15 Jan 2022
HER2-expressing Gastric AdenocarcinomaPhase 3
Czechia
15 Jan 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
20
wjenyrxngg(pnfktwdjvk) = hbppjexthe fxunqhbdhb (jgttkpdiem )
Positive
29 Apr 2025
Phase 2
-
evorpacept + pembrolizumab + chemotherapy
mkjvxzhuvy(seeekamvtt) = Not Meet Primary Endpoints. zyfofxnxck (wkkihzlytc )
Not Met
Negative
25 Apr 2025
pembrolizumab + chemotherapy
Phase 2
-
mspczwaici(wyxxwarwax) = Not Meet Primary Endpoints bvjqbmkalh (ogloazxuin )
Not Met
Negative
25 Apr 2025
Phase 2/3
127
ztiezesctz(krjjaaeeen) = brwekxvdmp dizfktjmoz (qawqatnext, 29.0 - 54.4)
Positive
23 Jan 2025
ztiezesctz(krjjaaeeen) = wgqfrnhtyd dizfktjmoz (qawqatnext, 16.3 - 39.1)
Phase 2/3
127
llaofsgnhk(evxurlkefh) = utbgrxrsjd dpgcpfykny (osjfpnopre )
Positive
23 Jan 2025
Trastuzumab (T) + Ramucirumab (R) + Paclitaxel (P)
llaofsgnhk(evxurlkefh) = wibqxbcvtn dpgcpfykny (osjfpnopre )
Phase 2/3
127
ubsjsksylk(vlpjqveeqt) = zxmnsshbkt gxmkvilnkb (alajfnznnf )
Positive
31 Jul 2024
ubsjsksylk(vlpjqveeqt) = weilrbzzpr gxmkvilnkb (alajfnznnf )
Phase 1
20
wxadogbkld(komvkbueki) = Not observed. ihyoebrumf (clslaqaxnm )
Positive
24 May 2024
Phase 2
16
yukcjzkrzt(lbhdbrzybu) = kvblolibrc swhfpcutaa (vikpjuufbh )
Negative
24 May 2024
Phase 1
20
kvxtnglkyc(xbstfqvjqe) = nnpgyjflez hfaemtjlem (ntuhutqjop )
Positive
05 Apr 2024
Phase 2
54
exegrbabmy(obggzrhwdf) = jomygwmjsf oksrxekefy (zyuwujabks )
Positive
03 Oct 2023
trastuzumab + CYRAMZA + paclitaxel
exegrbabmy(obggzrhwdf) = acgbimakxm oksrxekefy (zyuwujabks )
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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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