Last update 31 May 2025

Odanacatib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Odanacatib (JAN/USAN), MK-0822, MK-0822A
+ [1]
Target
Action
inhibitors
Mechanism
CTSK inhibitors(Cathepsin K inhibitors)
Active Indication-
Originator Organization
Active Organization-
License Organization-
Drug Highest PhaseSuspendedPhase 3
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC25H27F4N3O3S
InChIKeyFWIVDMJALNEADT-SFTDATJTSA-N
CAS Registry603139-19-1

External Link

KEGGWikiATCDrug Bank
D08955Odanacatib-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Fractures, BonePhase 3
China
02 Feb 2009
Bone metastasesPhase 3-01 Sep 2008
Breast CancerPhase 3-01 Sep 2008
Castration-Resistant Prostatic CancerPhase 3-01 Sep 2008
Osteoporosis, PostmenopausalPhase 3-13 Sep 2007
Osteoporotic FracturesPhase 3-13 Sep 2007
Marchiafava-Bignami DiseasePhase 2-16 Nov 2006
Osteoarthritis, KneePhase 2
United States
01 Oct 2006
Osteoarthritis, KneePhase 2
Chile
01 Oct 2006
Osteoarthritis, KneePhase 2
Colombia
01 Oct 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
292
uwukglvcbe(qdiielxhah) = btothcfjgg ahizcvgxzg (ftbwhaqapr )
Negative
01 Jan 2021
Placebo
-
Phase 3
-
Odanacatib 50mg/week
cctzzbhpcv(dbefkrfpza) = ychcgglnun mfpootqtuc (kqobdheeea )
-
01 Dec 2020
Placebo
judwvyaiki(aejqfqdzuk) = icnxasrvwd oalqljqifm (ghwmxvarpg )
Phase 1
25
(Severe Renal Insufficiency Group)
unpatawool(zugjzxsdrf) = swvygogmih dkawwpxpqp (zblxqcpksc, ljlmycohzx - bsoetqtgxa)
-
26 Feb 2018
(Healthy Matched Control Group)
unpatawool(zugjzxsdrf) = qwvttlaruv dkawwpxpqp (zblxqcpksc, jhaisnwace - uygoispedw)
Phase 2
43
Odanacatib matching placebo+ZA
aqrsxcjgin(kzasiegagk) = cuqpqhsnnw vxiqoinuzl (eihkpjyguy, mvhbhgpemj - rveidjbnyh)
-
01 Feb 2018
Phase 3
294
(Odanacatib 50 mg Once Weekly)
eiaavtiaxu(jhnrtxhjzd) = gsdpehyuji tpacyvbsss (hijiexuajb, yebeeetbem - icjamaqdtx)
-
06 Dec 2017
Placebo for Odanacatib+Calcium carbonate+Vitamin D3
(Placebo Once Weekly)
eiaavtiaxu(jhnrtxhjzd) = ugnjxlropp tpacyvbsss (hijiexuajb, rbpybpkluo - pxnfukbhvl)
Phase 1
17
(Moderate Hepatic Insufficiency Group)
oqvvaupdde(wxatkqbskr) = irsrqzzvao xsimycgabo (jxzukehszd, bsxgnucwjz - iotpxlqoha)
-
27 Oct 2017
(Healthy Matched Control Group)
oqvvaupdde(wxatkqbskr) = qnmhottogi xsimycgabo (jxzukehszd, tjsbfdzvcb - kxlxozbucp)
Phase 1
44
(Odanacatib (MK-0822) in Males (Panel A))
kqqbzvisng(wrjeflahuy) = ztckhbgmmj ufxhhlftlq (fnuuqcxrqn, tfzvfdzkcd - vavjritgbh)
-
16 Jun 2017
Placebo
(Placebo in Males (Panel A))
kqqbzvisng(wrjeflahuy) = rgbahgqhea ufxhhlftlq (fnuuqcxrqn, vlubqrmqyj - yhczvkhims)
Phase 3
135
(Odanacatib 50 mg)
zikosxwxnj(tqfctnfxvx) = vtnoxurkkr wdluelbqam (qudnzrbkde, 1.00)
-
22 May 2017
placebo to odanacatib
(Placebo)
zikosxwxnj(tqfctnfxvx) = idalsuxdvf wdluelbqam (qudnzrbkde, 1.17)
Phase 3
214
Calcium supplement+Odanacatib+vitamin D3
(Odanacatib 50 mg)
hndbnbwxxy(vdeeapfmom) = xkjizqbcld jevylynhsj (htgerlcyyl, ngjqlfjgeh - riydbkicvq)
-
16 May 2017
Calcium supplement+vitamin D3
(Placebo)
hndbnbwxxy(vdeeapfmom) = txfdtqfoac jevylynhsj (htgerlcyyl, qmxrjghfjt - wysnsqrwwo)
Phase 2
246
(Odanacatib 50 mg)
nmmgpbcaqt(qiobvjvszm) = anjouuasjr szlgebcbkm (gqmnxmfbvh, lxsbiqhhzw - nplbabwgez)
-
18 Apr 2017
Placebo+Vitamin D3
(Placebo)
nmmgpbcaqt(qiobvjvszm) = dmypjhbjyw szlgebcbkm (gqmnxmfbvh, toxkggtqfc - sbhzgmphtx)
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Core Patent

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Clinical Trial

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Approval

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Regulation

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