This study investigates the time course of change in calcium in the blood after a pregnant subject takes an oral dose of calcium carbonate (commonly marketed as "Tums"). This information is important for trials investigating whether calcium can reduce postpartum hemorrhage, bleeding after delivery.

Start Date01 Jan 2025

Sponsor / Collaborator

Stanford University

NCT06580782

/ RecruitingPhase 4IIT

Calcium Carbonate to Augment Labor Contractions

The investigators think that calcium carbonate can act as an assistive medication to improve contractions during labor.

Start Date18 Nov 2024

Sponsor / Collaborator

Weill Medical College of Cornell University

NCT06352775

/ Active, not recruitingNot ApplicableIIT

The Effect of Calcium Carbonate on Labor Induction: A Pilot Study

The investigators aim to evaluate the safety and efficacy of administering calcium carbonate to laboring participants undergoing labor inductions. The investigators hypothesize that calcium carbonate is a low-risk preventative measure to decrease oxytocin induction time and dosage, decrease the rate of labor dystocia, decrease the rate of cesarean deliveries, and demonstrate no differences in maternal or neonatal safety outcomes.

Start Date01 Jun 2024

Sponsor / Collaborator

Wake Forest School of Medicine

100 Clinical Results associated with Calcium carbonate

100 Translational Medicine associated with Calcium carbonate

100 Patents (Medical) associated with Calcium carbonate

134,154

Literatures (Medical) associated with Calcium carbonate

31 Dec 2025·Italian Journal of Animal Science

Effect of monobutyrate on growth performance, intestinal development, and cecum microbiota in broilers

Author: Liu, Chen ; Li, Yongneng ; Zhao, Sumei ; Tai, Yuan ; Qiu, Wencai ; Pan, Hongbin ; Yang, Minghua ; Huang, Ying

The prohibition of antibiotic growth promoters for animal production has created a demand to explore alternative feed additives to replace antibiotics.Monobutyrate has the potential to replace antibiotics.In this study, we investigated the effects of monobutyrate on broiler growth performance, intestinal development, and caecum microbiota.Total 240 1d-old Arbor Acres broilers were randomly divided into five groups.Each group had eight broilers, and the groups were replicated six times.The broilers were fed a basal diet (CK group), a basal diet containing 0.1% acetyl kitasamycin (Anti group), and basal diets containing 0.15‰, 0.30‰, and 0.45‰ monobutyrate (M1, M2 and M3 group) for 42 days.Compared with the CK group, F/G was significantly decreased in broilers in the M3 group (p <0.05).The relative length and weight of the duodenum were significantly higher in the M1, M2, and M3 groups than those in the CK group.Compared with the CK group, the relative ileum length was significantly increased in the M2 and M3 groups (p <0.05).Compared with those of the CK and Anti groups, Rikenellaceae, Alistipes, Sellimonas, and Ruminococcus_2 were enriched in the M3 group (p < 0.05).The results of this study indicated that monobutyrate promotes broiler growth performance, improves intestinal development, and regulates microbiota composition

01 Dec 2025·MOLECULAR BIOLOGY REPORTS

Overexpression of rice High-affinity Potassium Transporter gene OsHKT1;5 improves salinity and drought tolerance in Arabidopsis

Article

Author: Abdullah-Zawawi, Muhammad-Redha ; Uddin, Md Imtiaz ; Zainal, Zamri ; Sukiran, Noor Liyana ; Ullah, Mohammad Asad ; Razalli, Izreen Izzati

BACKGROUND:

Rice is subjected to various environmental stresses, resulting in significant production losses. Abiotic stresses, particularly drought and salinity, are the leading causes of plant damage worldwide. The High-affinity Potassium Transporter (HKT) gene family plays an important role in enhancing crop stress tolerance by regulating physiological and enzymatic functions.

METHODS AND RESULTS:

This study investigates the effect of overexpressing the rice HKT1;5 gene in Arabidopsis thaliana on its tolerance to salinity and drought. The OsHKT1;5 gene was introduced into Arabidopsis under the control of 35 S promoter of CaMV via floral dip transformation method. PCR confirmed the integration of the transgene into the Arabidopsis genome, while qPCR analysis showed its expression. Three transgenic lines of OsHKT1;5 were used for stress treatment and phenotypic studies. The overexpressed lines showed considerably higher germination rates, increased leaf counts, greater fresh and dry weights of the roots and shoots, higher chlorophyll contents, longer root lengths, and reduced Na⁺ levels together with increased K⁺ ions levels after salt and drought treatments, in comparison to wild-type plants. Furthermore, overexpressed lines exhibited higher antioxidant levels than wild-type plants under salinity and drought conditions. In addition, transgenic lines showed higher expression levels of the OsHKT1;5 gene in both roots and shoots compared to wild-type plants.

CONCLUSIONS:

In conclusion, this study revealed OsHKT1;5 as a promising candidate for enhancing tolerance to salinity and drought stresses in rice, marking a significant step toward developing a new rice variety with improved abiotic stress tolerance.

01 Jul 2025·SEPARATION AND PURIFICATION TECHNOLOGY

Capturing and converting CO2 using amino acids as various commercially valuable nano-carbonates

Author: Xing, Malcolm ; Li, Qingyang ; Qian, Yong ; Li, Bingyun

Carbon dioxide (CO₂) is the most significant greenhouse gas and one of the strategies to reduce CO₂ emission is to convert CO₂ into com. valuable products.Currently, methods that can effectively capture and convert CO₂ into carbonate nanomaterials, which have unique applications in various fields, have rarely been reported, and there are no universal methods that can capture and convert CO₂ into different nano-carbonates.In this study, an innovative two-step strategy based on amino acids was developed to produce multiple different carbonate nanoparticles, including CaCO₃, BaCO₃, and Ag₂CO₃ nanoparticles with diameters of 70 nm, 50 nm, and 7 nm, resp.Fundamentally important, the NMR data clearly demonstrated that it was the amino acids (e.g., glycine) that dictated the formation of carbonate nanoparticles.In the presence of amino acids, a competition in forming nanoparticles and microparticles was observed, and the formation of nanoparticles was proportional to the carbamate formed from CO₂ reacting with amino acids.In the absence of amino acids, carbonate microparticles (∼ 2μm) were formed.

News (Medical) associated with Calcium carbonate

08 Aug 2024

·www.echemi.com

After 2023 Snub, Amneal Clinches Approval for Extended-Release Parkinson's Disease Med Crexont

After a major setback in 2023, Amax Pharmaceuticals finally ushered in a brilliant victory in the United States, its signature innovative delayed release Parkinson's disease treatment drug - Crexont, successfully obtained the authoritative approval of the United States Food and Drug Administration (FDA). This unique oral calcium carbonate/levodopa (CD/LD) extended-release formulation opens a new chapter in the treatment of patients with Parkinson's disease with its superior efficacy and convenience, not only significantly extending their "well" period, but also reducing the number of burdensome daily doses to three times, greatly improving patients' quality of life. The FDA accepted Crexont's application after a thorough review and analysis of the detailed Phase III clinical trial data submitted by Amax. In this critical clinical trial of RISE-PD, Crexont stood out for its exceptional performance, providing patients with an additional 30 precious minutes of "good" time per day compared to traditional ready-to-release CD/LD. In addition, its average daily frequency of taking only three times, compared with five times for traditional drugs, undoubtedly brings unprecedented convenience to patients. The successful approval of Crexont is undoubtedly a significant milestone in the treatment of Parkinson's disease. In the face of the large population of patients in the United States - about 1 million people with Parkinson's disease, and about 90,000 new cases each year, the introduction of Crexont has undoubtedly brought unprecedented hope for patients. The co-ceos of Amax Pharmaceuticals, Chirag Patel and Chintu Patel, could not contain their excitement, saying that it is their greatest honor to bring this epoch-making new treatment to Parkinson's disease patients in the United States. At the same time, the company is also confidently planning to bring this innovative treatment to the international market. However, behind the success is often accompanied by unremitting efforts and challenges. Amax had previously been rejected by the FDA because of insufficient safety data on Crexont. This setback did not break them, but inspired them to be more determined and more rigorous. Now, with the successful approval of Crexont, the drug is expected to generate annual sales of up to $300 million to $500 million, further solidifying its leading position in the treatment of Parkinson's disease. It's worth noting that Amax is not alone. Abbott and Newrod Pharmaceuticals, among others, have faced similar regulatory challenges on the road to developing new levodopa preparations. These experiences show that despite the difficulties ahead, pharmaceutical companies are still working hard to find better treatments for Parkinson's disease. Amax's success has undoubtedly set an example for the entire industry, and has brought more treatment options and light of hope to patients with Parkinson's disease.

Phase 3Drug ApprovalClinical Result

27 Nov 2023

·www.prnewswire.com

Amorphical brings Scientific Breakthrough - Treating and Curing Chronic Inflammatory and Oncological Diseases

NES-ZIONA, Israel, Nov. 27, 2023 /PRNewswire/ -- An exclusive initiative by the Israeli biotechnology company Amorphical brings a breakthrough approach to treating a variety of chronic inflammatory and oncological diseases. Scientific Development and Breakthrough Amorphical has developed a pioneering technology to produce amorphous nano-minerals. The unique structure of these amorphous nano-minerals enables the efficient and rapid absorption of essential minerals in the body. Amorphous nano-minerals also possess a unique ability to stimulate healing mechanisms within the target damaged tissues. Amorphous Calcium Carbonate – Amorphical's Revolutionary Leading Product Calcium is a vital mineral for various physiological activities: bone formation, nerve conductivity, muscle function, boosting the immune system, and many other activities. Carbonate is a crucial molecule for maintaining the body's pH balance by neutralizing excess acidity. Treating the Cause for Disease, Not Just the Symptom Modern lifestyle, characterized by stress, unbalanced diet, and an increase in life expectancy, results in a reduced production of bicarbonate, essential for the proper function of the body. Consequently, the elevated tissue acidity impairs the ability to regulate inflammatory processes, ultimately leading to the development of chronic inflammatory as well as oncological diseases. Due to its unique structure and dissolving properties, unlike the crystalline mineral, the amorphous calcium carbonate can directly target inflamed or cancerous tissues. When amorphous carbonate calcium reaches the inflamed tissue, a neutralizing reaction occurs within the acidic environment. The resulting neutral environment does not support the inflammatory processes, leading to the desired healing. Neutralizing the acidic environment is also crucial in treating oncological diseases. Most oncological diseases are characterized by anaerobic respiration of cancer cells, creating an acidic environment within the tumor. This acidic environment supports the rapid division of cancer cells and the development of metastases, while preventing the immune system from attacking and eliminating the cancer cells. Neutralizing the acidic environment in the cancerous tissue by amorphous calcium carbonate inhibits the enhanced metabolic activity of the cancer cells, required for their rapid division. In parallel to the reduction in cancer cell proliferation, the neutralization of the acidic environment within the tumor allows the immune cells to resume their activity, and attack and destroy the cancer cells. To date, this is the sole technology capable of treating and curing a wide range of oncological diseases by transforming the cancerous environment into a healthy environment. Comparison to Current Medications Current medications for chronic inflammatory diseases primarily aim to alleviate symptoms rather than target the disease accelerator, which is the acidic environment within the inflamed tissue. In contrast, amorphous calcium carbonate neutralizes the acidic environment specifically in the inflamed tissue, and thus enables the healing of the inflammation. Conditions Suitable for Treatment by Amorphous Calcium Carbonate The innovative treatment with amorphous calcium carbonate promotes prompt and effective recovery across a variety of diseases: 1. Crohn's Disease, Multiple Sclerosis, Osteoporosis, Arthritis, Pulmonary diseases, and other chronic inflammatory diseases. 2. A wide range of oncological diseases including breast, prostate, colon, liver cancers, and more. 3. The treatment has proven to be highly effective in managing COVID-19. 4. The treatment significantly slows down aging processes and substantially improves the quality of life. Selected Scientific Publications on the Medical Activity of Amorphical's Nano-Amorphous Calcium Carbonate: Lung Cancer: Amorphous Calcium Carbonate Shows Anti-Cancer Properties That are Attributed to Its Buffering Capacity. Cancers (Basel). 2023 Jul 26;15(15):3785 Treatment for COVID-19: Sublingual and Inhaled Amorphous Calcium Carbonate for Hospitalized Patients with SARS-CoV-2: A Phase 1/2 Clinical Study. J Clin Trials. 2023 Vol.13 Iss. 4 No: 1000551 Effect on Mouse Embryos: The effect of amorphous calcium carbonate as a culture media supplement on embryonic development of murine sibling embryos. J Assist Reprod Genet. 2023 Oct;40(10):2409-2418 Additional articles describing the treatment with Amorphical's amorphous nano-minerals are presented on the company's website. For more information, please contact: Noga Nadel Erental - [email protected] Logo -

20 Nov 2023

·www.biospace.com

BioTech Medics Continues to Execute Its Calcium Business Plans

WOODLAND HILLS, CA / ACCESSWIRE / November 20, 2023 / BioTech Medics, Inc. (OTC PINK:BMCS) is pleased to announce that the Company continues to build the fundamental substructure that will enhance our ability to raise capital to position the organization in a competitive advantage with its calcium carbonate assets to enhance BMCS as a substantial publicly traded firm in this sector. Our website can be found at According to Anthony K. Miller, CEO, "As we previously reported, our business model is in the biotech ecosystem, encompassing calcium, calcium carbonate and related products. This month (November) management met with several brokers and market-makers to update and repost our company's 15c211.This updated 15c211 will allow BMCS stock to be more accessible to a larger market-maker base and remove the warning from our security. This action will add value to current and new shareholders, increase the tradability of our stock and give us greater credibility in the financial community; enhancing our ability to raise working capital. Additionally, management is actively moving to become a reporting issuer and elevate to the OTCQB or greater in 2024. We will also seek to reduce the I/O common shares once revenue starts to enhance our share value… All these activities are necessary so that BMCS can capitalize on its significant opportunities. This week management did BMCS 3Q financial filings and did position the Company's audit-ready financials for an imminent audit. We have solid alliance in the calcium sector, and we are comfortable with marketing our calcium to the larger US marketplace that will include a wide variety of products. Raising money for these opportunities is necessary to liberate all the opportunities before us. We are already entertaining purchase orders, and management will do whatever it can to materialize these opportunities and bring capital forward. Our revenue will begin this year (2023). Management expects that this is a long-term venture (with our own physical assets) lasting more than a decade once fully implemented. OUR FUTURE: This year management (after over 2 years trying to get our name change through FINRA) decided to abandon the name change and the digital asset business plan. Management decided to take the Company 100% back to its biotech roots and did initiate an agreement with certain asset holders in the Dominican Republic with calcium carbonate resources that boast of 3 billion+ metric ton reserves. On September 28, 202 because of a negotiated agreement BioTech Medics procured 2 million metric tons of very high quality (99.8% pure) calcium carbonate to market to a worldwide marketplace. This calcium carbonate has a base value of $30 million dollars (2 million tons @ $15.00 per ton). As management goes into the sales portals it is common that this same calcium carbonate (request for proposals-RFP) has common requested values in excess of $85.00 per metric ton (in the portals). Further note that this was a significant transaction that management negotiated for the firm since the assets were acquired for 2 million Series A preferred shares of stock. Finally, management did procure (along with this transaction) an option to acquire an additional 48 million metric tons of calcium carbonate at a similar transaction value. Our new business plan is an old school commodities plan where we mine our calcium… put in on a truck and then put it on a ship to send it to the client. This business model has traditional profit margins in excess of 33% per transaction. Follow the hyperlink to see actual images taken from our mine (we will continue to post real-time images in the future here)… located on our website commented Miller" About Calcium Carbonate: The global calcium carbonate market size was valued at USD 44.7 billion in 2022 and is expected to grow at a compound annual growth rate (CAGR) of 6.6% from 2023 to 2030. Increasing demand for paper from packaging applications and hygiene-related products like tissue paper is a significant growth driver. The U.S. has been a prominent destination for the product considering high demand from industries. Paper is the largest application segment of the market, and the U.S. is among the world's largest paper manufacturers. Calcium carbonate is also used as organic fertilizer, to produce calcium citrate (citric acid), which is used as a food additive, a preservative, an acidifier, or a flavoring agent. It is used in applications such as cleaning agents, cosmetics, pharmaceuticals, and dietary supplements. As utilized in building material, it helps to manufacture mortar that holds together tiles, rubber products, roofing tiles, concrete slabs and stones and is employed in paints and pigments. Additionally, baking powder, wine, dough, plastics, adhesives sealants and more. It is also used to adjust the pH value of water through the neutralization process. Calcium is a widely utilized commodity with tremendous applications. About BioTech Medics, Inc: BioTech Medics, Inc is a publicly traded Wyoming company traded on the OTC Markets under the stock symbol BMCS located in Los Angeles California. BioTech Medics Inc. has a long and successful history in the biotech sector. The firm going forward will focus on calcium, silica, carbon credits as its business model. Additionally, the firm still has significant other assets and now calcium assets position BMCS above $70 million dollars (transactions before us can increase or reduce those assets… ultimately all our assets are projected be calcium and silica… as the source of our revenue). Forward-Looking Statements: This press release contains "forward-looking statements" within the meaning of the safe harbour provisions of the U.S. Private Securities Litigation Reform Act of 1995. All statements, other than statements of historical fact, including those with respect to the expected projects of BioTech Medics, Inc., and related companies. All statements that are included in this Press release, other than statements of historical fact, are forward-looking statements. Forward-looking statements involve known and unknown risks, assumptions, uncertainties, and other factors. Statements made in the future tense, and statements using-words-such as "may, "can," "could," "should," "predict," "aim'" "potential," "continue," "opportunity," "intend " "goal," "estimate," "expect," "expectations," "project," "projections," "plans," "anticipates," "believe," "think," "confident" "scheduled" or similar expressions are intended to identify forward-looking statements. Forward-looking statements are not a guarantee of performance and are subject to a number of risks and uncertainties, many of which are difficult to predict and are beyond our control. These risks and uncertainties could cause actual results to differ materially from those expressed in or implied by the forward-looking statements, and therefore should be carefully considered. You should consider the areas of risk described in connection with any forward-looking statements that may be made herein. We caution you not to place undue reliance on the forward-looking statements, which speak only as of the date of this report and readers should carefully review this report in its entirety. We disclaim any obligation to update any of these forward-looking statements as a result of new information, future events, or otherwise, except as expressly required by law. Further information on our risk factors is contained in our filings with the OTC Markets and the SEC website. Any forward-looking statement made by us herein speaks only as of the date on which it is made. Factors or events that could cause our actual results to differ may emerge from time to time, and it is not possible for us to predict all of them. We undertake no obligation to publicly update any forward-looking statement, whether as a result of new information, future developments or otherwise, except as may be required by law. CONTACT INFORMATION INVESTOR RELATIONS STOCK SYMBOL: (BMCS-OTC) EMAIL: tonymillertmiller@gmail.com or tmiller@biotechmedics.co WEBSITE: PHONE: 800.988.3782/ 661.544.0275 LOCATION: WOODLAND HILLS, CA. SOURCE: BioTech Medics Inc. View source version on accesswire.com:

100 Deals associated with Calcium carbonate

External Link

KEGG	Wiki	ATC	Drug Bank
D00932	Calcium carbonate	A12AA04 A02AC01	DB06724

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Hyperphosphatemia	Japan	Pfizer Japan, Inc.	16 Jun 1999
Hyperphosphatemia	Japan	Mylan Seiyaku Ltd.	16 Jun 1999
Osteoporosis	China	Haleon (Suzhou) Pharmaceutical Co. Ltd.	-

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Gastroesophageal Reflux	Phase 2	Japan	Otsuka Pharmaceutical Co., Ltd.	31 Oct 2017
Hyperchlorhydria	Phase 2	Japan	Otsuka Pharmaceutical Co., Ltd.	01 Aug 2014
Bone metastases	Phase 1	Israel	Amorphical Ltd.	01 Jun 2022
Castration-Resistant Prostatic Cancer	Phase 1	Israel	Amorphical Ltd.	01 Jun 2022
Adrenocortical Carcinoma	Phase 1	Israel	Amorphical Ltd.	25 Jun 2017
Secondary malignant neoplasm of lung	Phase 1	Israel	Amorphical Ltd.	25 Jun 2017
HIV Infections	Phase 1	-	ViiV Healthcare Ltd.	01 Dec 2012

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ENDO2023	Not Applicable	ST Elevation Myocardial Infarction	-	Calcitonin	jeyhzdslcg(ipumykisll) = euldcgxkac fzdiwwyexx (mguohnpdxn ) View more	Positive	05 Oct 2023
NCT02186600 (HOPS, CTgov)	Phase 3	Osteoporosis	276	Calcium Carbonate+Vitamin D3 (Control)	rhxozuhoie(ceoprnkuff) = uhhaebriir pptbjqhnwx (catdoniamj, 334.7) View more	-	27 Jun 2023
				Risedronate+Calcium Carbonate+Vitamin D3 (Risedronate)	rhxozuhoie(ceoprnkuff) = ncomjbbkxw pptbjqhnwx (catdoniamj, 292.3) View more
WCO_IOF_ESCEO2021	Not Applicable	Hypoparathyroidism	24	Calcium Citrate	tdjjcqvhup(exeptetlvm) = zmfqvmuhlu ughhcxnudi (lyyvjtttjk )	Positive	26 Aug 2021
				Calcium Carbonate	tdjjcqvhup(exeptetlvm) = rtwtgvrhhm ughhcxnudi (lyyvjtttjk )
ASN2019	Not Applicable	-	37	Calcium Carbonate	gickkfymrk(tgtdkheadw) = lexlxtnqcu rywtkkgesy (cvinbhykwn, 7 - 14) View more	Negative	05 Nov 2019
				Sevelamer	gickkfymrk(tgtdkheadw) = vqiewwbjes rywtkkgesy (cvinbhykwn, 3 - 19) View more
NCT03089216 (CTgov)	Phase 4	Dentin Sensitivity	108	Combined Bleaching(2x20) (Combined Bleaching(2x20))	njgkpmelmk(rvsfqnoebe) = prqveapaxe gfyeafvvwu (kbkzqzasgy, dxhxrppyme - qsrjwvgmev) View more	-	05 Aug 2019
				Combined Bleaching (1x20) (Combined Bleaching(1x20))	njgkpmelmk(rvsfqnoebe) = ennqowuwvh gfyeafvvwu (kbkzqzasgy, vfnyzpwcix - bxktyomogx) View more
ISN WCN2019	Not Applicable	-	-	Calcium Carbonate	jxouttysnd(ohkdjgunso) = olwrqwfpsx qzrguouyvs (gttwdslmhi )	-	01 Jul 2019
				Sevelamer Hydrochloride	jxouttysnd(ohkdjgunso) = lwqiczxjxq qzrguouyvs (gttwdslmhi )
NCT00620113 (0822-022 \| MK-0822-022, CTgov)	Phase 2	Osteoporosis, Postmenopausal	287	Placebo+Calcium carbonate+Vitamin D3 (Placebo)	oeferhbjdx(sbukceljdq) = hejndfofsz eytvksijmt (vhsyxjziri, ksaovzeowl - ydtjbshgzm) View more	-	13 Mar 2017
				Odanacatib+Calcium carbonate+Vitamin D3 (Odanacatib 10 mg)	oeferhbjdx(sbukceljdq) = yhnqmbcxar eytvksijmt (vhsyxjziri, mfnevtqhgm - haxxnvqylh) View more
AN OPEN-LABEL \| SINGLE CENTER STUDY (WCO_IOF_ESCEO2016)	Not Applicable	Hypoparathyroidism	10	Crystalline Calcium Carbonate Supplement (CCS)	lzhgtcvylv(wacmstwbnl) = One patient had asymptomatic hypocalcemia during physical activity ghbhrlesnn (rynsrkwnhp ) View more	-	17 May 2016
NCT00073073 (CTgov)	Phase 2	Noninfiltrating Intraductal Carcinoma \| Invasive Mammary Carcinoma	46	Vitamin D+Exemestane+Calcium carbonate	tflggumiul(hstnrdbmci) = gyldqlsbir tfcbsbrcfm (xgjoufbamc, esqxrfkxfp - iqpcxrwfka) View more	-	17 May 2016

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