The Investigators have demonstrated in preclinical studies that RNA liposomes activate APCs, induce antigen-specific T cell immunity, and can supplant DCs in a cell therapy model for HGG and have shown feasibility and activity of this approach in preclinical models and in canine patients with a spontaneous malignant glioma. In one arm of this study, we will investigate the safety and immunologic activity of RNA-LP vaccines in pediatric patients with recurrent pHGG.
The investigators have also shown that intravenous administration of tumor mRNA loaded lipid particles (LPs) localizes primarily to lung, transfect antigen presenting cells (APCs) and lead to an activated T cell response for induction of anti-tumor immunity. In contrast to other formulations, RNA-LPs recruit multiple arms of the immune system (i.e. innate/adaptive), and remodel the systemic/intratumoral immune milieu, which remain potent barriers for vaccine, cellular, and checkpoint inhibiting immunotherapies. After only a single RNA-LP vaccine, the bulk of systemic and intratumoral dendritic cells (DCs) in mice display an activated phenotype; these activated DCs (harvested from tumors) expand antigen specific T cell immunity. In immunologically resistant pulmonary osteosacroma murine tumor models (i.e. K7M2), RNA-LPs induce robust anti-tumor efficacy in settings where immune checkpoint inhibitors (i.e. anti-PD-L1 therapy) do not confer therapeutic benefit. The investigators have already demonstrated safety of RNA-LPs in acute/chronic murine toxicity studies, and in client-owned canine trial.
In this study, we will investigate the manufacturing feasibility, safety and immunologic activity of RNA-LP vaccine in patients with recurrent pulmonary or unresectable osteosarcoma and recurrent pHGG.

Start Date10 Mar 2025

Sponsor / Collaborator

University of Florida

[+4]

NCT04299880

/ CompletedPhase 1

A Rollover Study to Provide Continued Access to Napabucasin for Patients Enrolled in Boston Biomedical-sponsored Napabucasin Protocols

This is an open-label, multi-center, multi-national, non-randomized rollover study designed to allow continued access to napabucasin for patients who have participated in a Boston Biomedical-sponsored study and are being treated with napabucasin (monotherapy or combination) and who are deriving continued clinical benefit in the parent study at the time of closure.

Start Date24 Feb 2020

Sponsor / Collaborator

Sumitomo Pharma America, Inc.

CTR20180947

/ RecruitingPhase 3

评价GB201联合紫杉醇和低剂量吉西他滨在一线治疗失败的转移性胰腺癌有效性和安全性的Ⅲ期临床研究

[Translation] Phase III clinical study to evaluate the efficacy and safety of GB201 combined with paclitaxel and low-dose gemcitabine in patients with metastatic pancreatic cancer who have failed first-line treatment

在一线治疗失败的转移性胰腺癌患者中对GB201联合紫杉醇和低剂量吉西他滨与标准治疗方案的总生存期（OS）的比较

[Translation]

Comparison of overall survival (OS) of GB201 combined with paclitaxel and low-dose gemcitabine versus standard of care in patients with metastatic pancreatic cancer who have failed first-line therapy

Start Date25 Oct 2018

Sponsor / Collaborator

1globe Health Institute LLC

[+2]

100 Clinical Results associated with Napabucasin

100 Translational Medicine associated with Napabucasin

100 Patents (Medical) associated with Napabucasin

267

Literatures (Medical) associated with Napabucasin

07 Mar 2025·Neuro-Oncology

Targeted delivery of napabucasin with radiotherapy improves outcomes in diffuse midline glioma

Article

Author: Wang, Yi-Fang ; Kinslow, Connor J ; Wu, Cheng-Chia ; Canoll, Peter ; Wechsler-Reya, Robert J ; Kokossis, Danae ; Zacharoulis, Stergios ; Cheng, Simon K ; Fernández, Ester Calvo ; De Los Santos, Genesis ; Angel, J Carlos ; Bruce, Jeffrey N ; Feldstein, Neil A ; Garvin, James H ; Wei, Hong-Jian ; Tomassoni, Lorenzo ; Zhang, Xu ; White, Erin ; Duan, Shoufu ; Zhang, Zhiguo ; Califano, Andrea ; Gallitto, Matthew ; Gartrell, Robyn D ; Yoh, Nina ; Pavisic, Jovana ; Berg, Xander ; Chio, Iok In Christine ; Sedor, Geoffrey ; Zandkarimi, Fereshteh

AbstractBackgroundDiffuse midline glioma (DMG) is the most aggressive primary brain tumor in children. All previous studies examining the role of systemic agents have failed to demonstrate a survival benefit; the only standard of care is radiation therapy (RT). Successful implementation of radiosensitization strategies in DMG remains an essential and promising avenue of investigation. We explore the use of Napabucasin, an NAD(P)H quinone dehydrogenase 1 (NQO1)-bioactivatable reactive oxygen species (ROS)-inducer, as a potential therapeutic radiosensitizer in DMG.MethodsIn this study, we conduct in vitro and in vivo assays using patient-derived DMG cultures to elucidate the mechanism of action of Napabucasin and its radiosensitizing properties. As penetration of systemic therapy through the blood-brain barrier (BBB) is a significant limitation to the success of DMG therapies, we explore focused ultrasound (FUS) and convection-enhanced delivery (CED) to overcome the BBB and maximize therapeutic efficacy.ResultsNapabucasin is a potent ROS-inducer and radiosensitizer in DMG, and treatment-mediated ROS production and cytotoxicity are dependent on NQO1. In subcutaneous xenograft models, combination therapy with RT improves local control. After optimizing targeted drug delivery using CED in an orthotopic mouse model, we establish the novel feasibility and survival benefit of CED of Napabucasin concurrent with RT.ConclusionsAs nearly all DMG patients will receive RT as part of their treatment course, our validation of the efficacy of radiosensitizing therapy using CED to prolong survival in DMG opens the door for exciting novel studies of alternative radiosensitization strategies in this devastating disease while overcoming limitations of the BBB.

01 Feb 2025·Biomaterials

Napabucasin deactivates STAT3 and promotes mitoxantrone-mediated cGAS-STING activation for hepatocellular carcinoma chemo-immunotherapy

Article

Author: Zhang, Xuemei ; Li, Yutong ; Liao, Anqi ; Wang, Lingzhi ; Yu, Shihan ; Guo, Jianfeng ; Zhou, Xinyi ; Li, Zhuo ; Zou, Yifang ; Shi, Jia ; Yang, Leilei ; Liu, Xiaobo ; Bi, Shengnan ; Yu, Zhuo ; Gao, Yuqiong

The immune resistance of tumor microenvironment (TME) causes immune checkpoint blockade therapy inefficient to hepatocellular carcinoma (HCC). Emerging strategies of using chemotherapy regimens to reverse the immune resistance provide the promise for promoting the efficiency of immune checkpoint inhibitors. The induction of cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) in tumor cells evokes the adaptive immunity and remodels the immunosuppressive TME. In this study, we report that mitoxantrone (MIT, a chemotherapeutic drug) activates the cGAS-STING signaling pathway of HCC cells. We provide an approach to augment the efficacy of MIT using a signal transducer and activator of transcription 3 (STAT3) inhibitor called napabucasin (NAP). We prepare an aminoethyl anisamide (AEAA)-targeted polyethylene glycol (PEG)-modified poly (lactic-co-glycolic acid) (PLGA)-based nanocarrier for co-delivery of MIT and NAP. The resultant co-nanoformulation can elicit the cGAS-STING-based immune responses to reshape the immunoresistant TME in the mice orthotopically grafted with HCC. Consequently, the resultant co-nanoformulation can promote anti-PD-1 antibody for suppressing HCC development, generating long-term survival, and inhibiting tumor recurrence. This study reveals the potential of MIT to activate the cGAS-STING signaling pathway, and confirms the feasibility of nano co-delivery for MIT and NAP on achieving HCC chemo-immunotherapy.

01 Jan 2025·Cytokine & Growth Factor Reviews

Insights into IL-6/JAK/STAT3 signaling in the tumor microenvironment: Implications for cancer therapy

Review

Author: Ho, Paul Chi-Lui ; Wang, Lingzhi ; Goh, Boon Cher ; Wong, Andrea Li-Ann ; Thuya, Win Lwin ; Zhou, Jianbiao ; Nicot, Christophe ; Cao, Yang

The IL-6/JAK/STAT3 signaling pathway is a key regulator of tumor progression, immune evasion, and therapy resistance in various cancers. Frequently dysregulated in malignancies, this pathway drives cancer cell growth, survival, angiogenesis, and metastasis by altering the tumor microenvironment (TME). IL-6 activates JAK kinases and STAT3 through its receptor complex, leading to the transcription of oncogenic genes and fostering an immunosuppressive TME. This environment recruits tumor-associated macrophages (TAMs), cancer-associated fibroblasts (CAFs), and regulatory T cells (Tregs), collectively supporting immune evasion and tumor growth. IL-6/JAK/STAT3 axis also contributes to metabolic reprogramming, such as enhanced glycolysis and glutathione metabolism, helping cancer cells adapt to environmental stresses. Therapeutic targeting of this pathway has gained significant interest. Strategies include monoclonal antibodies against IL-6 or its receptor (e.g., Tocilizumab, Siltuximab), JAK inhibitors (e.g., Ruxolitinib), and STAT3-specific inhibitors (e.g., Napabucasin), which have exhibited promise in preclinical and initial clinical studies. These inhibitors can suppress tumor growth, reverse immune suppression, and enhance the efficacy of immunotherapies like immune checkpoint inhibitors. Combination therapies that integrate IL-6 pathway inhibitors with conventional treatments are particularly promising, addressing resistance mechanisms and improving patient outcomes. Advances in biomarker-driven patient selection, RNA-based therapies, and isoform-specific inhibitors pave the way for more precise interventions. This review delves into the diverse roles of IL-6/JAK/STAT3 signaling in cancer progression, therapeutic strategies targeting this pathway, and the potential for integrating these approaches into personalized medicine to enhance treatment outcomes.

News (Medical) associated with Napabucasin

05 Oct 2023

·synapse.patsnap.com

Tumor Killers: STAT3 inhibitors

Signal transducer and activator of transcription (STAT) is a class of proteins with dual functions of cytoplasmic signal transduction and nuclear transcription activation, widely found in mammalian cells, mediating a variety of intracellular signal pathways. Although STAT family members are highly homologous, their functions are vastly diverse. STAT3 is a signaling molecule expressed in various tissues. STAT3 can be activated by various factors, including cytokines, growth factors, neuroendocrine factors, ischemic hypoxic stimuli, etc. As a functionally diversified transcription factor, STAT3 can interact with a large number of signal molecules and forms various intra- and extracellular signal pathways. STAT3 is involved in a variety of biological processes, including cell proliferation, survival, differentiation and angiogenesis. In normal cells, STAT3 is transiently activated by phosphorylation to transmit the transcription signals of cytokine and growth factor receptors on the plasma membrane to the nucleus. Studies have shown that persistently activated STAT3 is essential for various cancers, such as breast cancer and colorectal cancer, making STAT3 an ideal drug target. However, STAT3 becomes excessively activated in most human cancers, usually associated with poor clinical prognosis. Through signal transduction and transcription activation, STAT3 participates in complex and varied life activities in biological bodies and is a current research hotspot. The research on STAT3 in the field of tumors has already achieved staged results. As the convergence point of multiple tumor pathways, STAT3 is persistently highly expressed in tumor cells and can promote tumor cell proliferation, resist cell apoptosis, mediate oncogenic inflammation, and inhibit anti-tumor immunity, etc. STAT3 has become an important molecular target for tumor treatment to a certain extent! STAT3 Competitive LandscapeAccording to the data provided by Patsnap Synapse-Global Drug Intelligence Database: the following figure shows that as of 25 Sep 2023, there are a total of 85 STAT3 drugs worldwide, from 92 organizations, covering 103 indications, and conducting 161 clinical trials. 👇Please click on the picture link below for free registration or login directly if you have freemium accounts, you can browse the latest research progress on drugs , indications, organizations, clinical trials, clinical results, and drug patents related to this target. The analysis of the current competitive landscape and future development of target STAT3 reveals that multiple companies are actively involved in the research and development of drugs targeting this specific target. The highest stage of development is the approved stage, with companies like Verta, Inc., Beijing Union Pharmaceutical Factory, and Sumitomo Chemical Co., Ltd. leading the way. Neoplasms and hepatocellular carcinoma are among the indications with approved drugs. Small molecule drugs are progressing rapidly, followed by antisense oligonucleotides, AAV-based gene therapy, and PROTACs. China, the United States, and various countries in the European Union are developing rapidly under the target STAT3. Further analysis is required to understand the competition around innovative drugs and the research and development institutions involved in biosimilars. Overall, the target STAT3 shows promising potential for the development of new drugs in the pharmaceutical industry. STAT3 inhibitors entering into Phase III clinical trials: NapabucasinNapabucasinis a small molecule drug that targets STAT3, a protein involved in various cellular processes, including cell growth and survival. It has shown potential therapeutic benefits in several therapeutic areas, including neoplasms, digestive system disorders, nervous system diseases, endocrinology and metabolic diseases, and respiratory diseases. 👇Please click on the image below to directly access the latest data (R&D Status | Core Patent | Clinical Trial | Approval status in Global countries) of this drug. In terms of specific indications, Napabucasin has demonstrated activity against pancreatic cancer, pancreatic ductal carcinoma, non-small cell lung cancer, colorectal cancer, stomach cancer, esophageal carcinoma, glioblastoma, hepatocellular carcinoma, gastrointestinal neoplasms, and liver cancer. These indications cover a wide range of cancers affecting different organs and systems in the body. The drug is developed by Pharmaceutics International, Inc., an originator organization in the pharmaceutical industry. It has reached Phase 3 of clinical development globally and in China. Phase 3 trials are the final stage of clinical development before seeking regulatory approval. Napabucasin has been designated as an orphan drug, indicating that it is intended to treat rare diseases or conditions. This regulatory status provides certain incentives and benefits to the drug's developer, such as market exclusivity and financial incentives, to encourage the development of treatments for rare diseases. Based on the available information, Napabucasin shows promise as a potential treatment for various types of cancer and other diseases. However, further clinical trials and regulatory approvals are necessary to establish its safety and efficacy. The drug's specific mechanism of action, potential side effects, and other relevant details are not provided in the given information. Therefore, a comprehensive analysis of the drug's potential and its competitive landscape would require additional data and research. STAT3 inhibitors entering into Phase II clinical trials: DanvatirsenDanvatirsen is an antisense oligonucleotide drug that targets STAT3, a protein involved in various cellular processes, including cell growth and survival. It is being developed by Ionis Pharmaceuticals, Inc. and has reached Phase 2 of clinical trials, both globally and in China. The therapeutic areas targeted by Danvatirsen include neoplasms (abnormal growth of cells), immune system diseases, hemic and lymphatic diseases, digestive system disorders, endocrinology and metabolic diseases, skin and musculoskeletal diseases, respiratory diseases, urogenital diseases, and other diseases. This broad range of therapeutic areas suggests that Danvatirsen has the potential to be used in the treatment of various conditions. 👇Please click on the image below to directly access the latest data (R&D Status | Core Patent | Clinical Trial | Approval status in Global countries) of this drug. The drug's active indications include recurrent squamous cell carcinoma of the head and neck, squamous cell carcinoma of head and neck metastatic, triple-negative breast cancer, bladder cancer, non-small cell lung cancer, pancreatic cancer, colorectal cancer, head and neck neoplasms, ascites (abnormal accumulation of fluid in the abdomen), hepatocellular carcinoma (liver cancer), non-Hodgkin lymphoma, and diffuse large B-cell lymphoma. As an antisense oligonucleotide, Danvatirsen works by binding to the messenger RNA (mRNA) molecules that carry the instructions for producing STAT3 protein. By binding to these mRNA molecules, Danvatirsen prevents the production of STAT3 protein, thereby inhibiting its activity. This approach offers a targeted and specific way to interfere with the function of STAT3, which is known to play a role in the development and progression of various cancers. The fact that Danvatirsen has reached Phase 2 of clinical trials indicates that it has shown promising results in earlier stages of testing, such as Phase 1 trials. Phase 2 trials involve a larger number of participants and aim to further evaluate the drug's safety and effectiveness. The inclusion of China in the highest phase of development suggests that Ionis Pharmaceuticals, Inc. recognizes the potential market and demand for Danvatirsen in this country. In summary, Danvatirsen is an antisense oligonucleotide drug developed by Ionis Pharmaceuticals, Inc. that targets STAT3. It has shown potential in a wide range of therapeutic areas, particularly in the treatment of various cancers. With its current highest phase being Phase 2, Danvatirsen is undergoing further evaluation to determine its safety and effectiveness.

21 Dec 2022

·www.prnewswire.com

Gastric Cancer Pipeline Space Brims With Novel Emerging Therapies with Over 200 Key Companies Working in the Domain | DelveInsight

The prevalence of gastric cancer has been rising since the past few years, which prompts the growing demand for treatment options. The increasing prevalence of cancer, the robust pipeline, and the growing research and development activities to develop novel therapies to treat Gastric Cancer drive the market. The companies developing the potential therapies in the last stage of development include Henlix Biotech, Eli Lilly and Company, Jiangsu Hengrui Medicine, and several others. LAS VEGAS, Dec. 21, 2022 /PRNewswire/ -- DelveInsight's ' Gastric Cancer Pipeline Insight – 2022 ' report provides comprehensive global coverage of available, marketed, and pipeline gastric cancer therapies in various stages of clinical development, major pharmaceutical companies are working to advance the pipeline space and future growth potential of the gastric cancer pipeline domain. Key Takeaways from the Gastric Cancer Pipeline Report DelveInsight's gastric cancer pipeline report depicts a robust space with 200+ active players working to develop 230+ pipeline therapies for gastric cancer treatment. Key gastric cancer companies such as EMD Serono, Sumitomo Pharma, LintonPharm Co., Ltd., Rapa Therapeutics LLC, Jiangsu HengRui Medicine Co., Ltd., Janssen Pharmaceutical K.K., Genentech, Exelixis, Bristol-Myers Squibb, Pieris Pharmaceuticals, Inc., Pfizer, Leap Therapeutics, CSPC ZhongQi Pharmaceutical, Ellipses Pharma, Amgen, Hanmi Pharmaceutical, Taiho Oncology, Inc., Shanghai Henlius Biotech, LianBio LLC, Chengdu Kanghong Biotech,Eisai Inc., AB Science, Maxinovel Pharmaceuticals, Shanghai Miracogen Inc., GlaxoSmithKline, Hoffmann-La Roche, Merck Sharp & Dohme, Hutchison Medipharma Limited, Genome & Company, Minneamrita Therapeutics LLC, Suzhou Suncadia Biopharmaceuticals Co., Ltd., MacroGenics, ALX Oncology Inc., Codiak BioSciences, Turning Point Therapeutics, Inc., TCRx Therapeutics, InxMed (Shanghai) Co., Ltd., Imugene Limited, SOTIO Biotech, CARsgen Therapeutics Co., Ltd., Zymeworks Inc., NextCure, Inc., Phanes Therapeutics, Pieris Pharmaceuticals, Inc., Athenex, Inc., Curis, Inc., Qurient Co., Ltd., Acepodia Biotech, Inc., Sichuan Baili Pharmaceutical Co., Ltd., Tarus Therapeutics, Inc., Lumicell, Inc., Legend Biotech,Cue Biopharma, TORL Biotherapeutics, LLC, OBI Pharma, Inc, Astellas Pharma, HiberCell, Inc., Celon Pharma SA, Linnaeus Therapeutics, Inc., Inspirna, Inc., Klus Pharma Inc., Genzada Pharmaceuticals, Shanghai PerHum Therapeutics, VM Oncology, LLC, Immunomic Therapeutics, Peptron, and others are evaluating new gastric cancer drugs to improve the treatment landscape. Promising gastric cancer pipeline therapies in various stages of development include Avelumab, BBI608, Camrelizumab, Catumaxomab, RAPA-201, SHR-1210, Amivantamab, Atezolizumab, Bevacizumab, Cabozantinib, Cinrebafusp alfa, Crizotinib, DKN-01, DP303c, Eflornithine, EP0057, Epacadostat, FLX475, Futibatinib, GEN-001, HLX07, HLX22, Infigratinib, KH903, Lenvatinib, Masitinib, MAX-40279, MRG002, MRG003, Niraparib, Savolitinib, Minnelide, SHR-1701, Margetuximab, Bemarituzumab, Evorpacept, Lenvatinib, CDK-004, TPX-0022, TCRx_T Cells, IN10018, IMU-131, SOT102, CT041, AB011, Zanidatamab, NC410, PT 886, PRS-343, Oraxol, CA-4948, Q702, ACE1702, SI-B001, TT-4, LUM015, LB 1908, CUE-102, TORL-2-307-MAB, OBI-833/OBI-821, ASP2138, NC410, SO-C101, HC-5404-FU, CPL304110, LNS8801, RGX-202-01, A166, GZ17-6.02, HMPL-453, CCT303-406, VMD-928, ITI 4000, PAb 001, and others. In December 2022, Daiichi Sankyo and AstraZeneca's ENHERTU (trastuzumab deruxtecan) has been approved in the European Union (EU) as a monotherapy for the treatment of adult patients with advanced HER2 positive gastric or gastroesophageal junction (GEJ) adenocarcinoma who have received a prior trastuzumab-based regimen. In December 2022, RemeGen Co., Ltd. announced on December 7, 2022, that its latest antibody-drug conjugate (ADC), RC118 for injection, has been granted two orphan drug designations (ODD) by the United States Food and Drug Administration (FDA) for gastric cancer (including gastroesophageal junction cancer) and pancreatic cancer. This marks the Company's fourth, having previously been twice granted ODD for Disitamab Vedotin (RC48) and Telitacicept (RC18) earlier this year. In December 2022, Zhejiang Doer Biologics Co., Ltd. announced that it has entered into a clinical trial collaboration agreement with MSD (Merck & Co., Inc., Rahway, NJ, USA), to investigate Doer Bio's anti-Claudin18.2 antibody DR30303, in combination with MSD's anti-PD-1 therapy, KEYTRUDA® (pembrolizumab), in patients with Gastric or Gastroesophageal Junction Cancer. Under this agreement, Doer Bio will conduct a clinical study based on a mutually- agreed and finalized protocol to evaluate the safety and efficacy of DR30303 in combination with KEYTRUDA® in patients with Claudin18.2-positive, locally advanced unresectable or metastatic gastric or gastroesophageal junction (GC/GEJ) cancer. In November 2022, Triumvira Immunologics announced preclinical data for its investigational TAC-T cell therapies CLDN18.2-TAC T and GUCY2C-TAC T, and data on HER2-specific TAC-T products. Data was shared in three posters at the Society for Immunotherapy of Cancer (SITC) 37th Annual Meeting being held virtually and in-person in Boston.Triumvira announced updated data on its novel T cell antigen coupler (TAC)-T cell candidate targeting Claudin 18.2 (CLDN18.2) for the treatment of gastric cancer. The data continue to demonstrate that CLDN18.2-TAC T effectively eliminates CLDN18.2-expressing gastric cancer cells in vitro and in vivo. The study also demonstrated that the activation of CLDN18.2-TAC T cells was specific to target cells that expressed CLDN18.2. In vitro data show strong and persistent anti-tumor activity and in vivo treatment led to complete and sustained tumor clearance with no signs of toxicity. In September 2022, Nuvectis Pharma, Inc. announced positive data for NXP800 in a preclinical xenograft model of ARID1a-mutated gastric carcinoma.Mice in each group were treated with either vehicle or NXP800, and tumor volumes were measured over 28 days. Treatment with NX800 resulted in tumor regression and substantial tumor growth inhibition versus the control. In March 2022, Imugene (ASX: IMU) announced a new clinical trial collaboration and supply agreement with MSD, a tradename of Merck & Co., Inc., Kenilworth, NJ, USA, to evaluate the safety and efficacy of Imugene's HER-Vaxx, B-cell activating immunotherapy, in combination with MSD's anti-PD-1 therapy, pembrolizumab (KEYTRUDA®), in patients with HER-2 positive gastric cancer. Request a sample and discover the recent advances in gastric cancer drug treatment @ Gastric Cancer Pipeline Report The gastric cancer pipeline report provides detailed profiles of pipeline assets, a comparative analysis of clinical and non-clinical stage gastric cancer drugs, inactive and dormant assets, a comprehensive assessment of driving and restraining factors, and an assessment of opportunities and risks in the gastric cancer clinical trial landscape. Gastric Cancer Overview Stomach cancer is cancer that begins within the stomach or on the stomach wall. It is also known as gastric cancer. Stomach cancer is more common in the elderly. People aged 75 and above account for approximately 50 out of every 100 cases (around 50%). It affects men more than women. The exact gastric cancer causes are not known. Stomach cancer is linked to Helicobacter pylori, a bacteria that lives in the stomach. The most common gastric cancer symptoms are difficulty swallowing (dysphagia), weight loss, persistent indigestion (dyspepsia), feeling full after eating small amounts, feeling or being sick, and fatigue due to low red blood cell count (anaemia). Several tests, such as ultrasound, imaging tests, blood tests, and others, are used for gastric cancer diagnosis. Gastric cancer patients can receive a variety of treatments. Standard gastric cancer treatment consists of seven types: surgery, endoscopic mucosal resection, chemotherapy, radiation therapy, chemoradiation, targeted therapy, and immunotherapy. Find out more about chemotherapy drugs for gastric cancer @ New Gastric Cancer Drugs A snapshot of the Gastric Cancer Pipeline Drugs mentioned in the report: Learn more about the emerging gastric cancer pipeline therapies @ Gastric Cancer Clinical Trials Gastric Cancer Therapeutics Assessment The gastric cancer pipeline report proffers an integral view of gastric cancer emerging novel therapies segmented by stage, product type, molecule type, mechanism of action, and route of administration. Scope of the Gastric Cancer Pipeline Report Coverage: Global Therapeutic Assessment By Product Type: Mono, Combination, Mono/Combination Therapeutic Assessment By Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III Therapeutics Assessment By Route of Administration: Oral, Parenteral, Intravenous, Subcutaneous, Topical Therapeutics Assessment By Molecule Type: Monoclonal Antibody, Peptides, Polymer, Small molecule, Gene therapy Therapeutics Assessment By Mechanism of Action: Antibody-dependent cell cytotoxicity, Programmed cell death-1 receptor antagonists, T lymphocyte stimulants, Apoptosis stimulants, Macrophage stimulants, Natural killer cell stimulants, Cyclin-dependent kinase 4 inhibitors, Cyclin-dependent kinase 6 inhibitors, Antibody-dependent cell cytotoxicity, Angiogenesis inhibitors, Epidermal growth factor receptor antagonists, EIF 2 kinase inhibitors Key Gastric Cancer Companies: EMD Serono, Sumitomo Pharma, LintonPharm Co., Ltd., Rapa Therapeutics LLC, Jiangsu HengRui Medicine Co., Ltd., Janssen Pharmaceutical K.K., Genentech, Exelixis, Bristol-Myers Squibb, Pieris Pharmaceuticals, Inc., Pfizer, Leap Therapeutics, CSPC ZhongQi Pharmaceutical, Ellipses Pharma, Amgen, Hanmi Pharmaceutical, Taiho Oncology, Inc., Shanghai Henlius Biotech, LianBio LLC, Chengdu Kanghong Biotech,Eisai Inc., AB Science, Maxinovel Pharmaceuticals, Shanghai Miracogen Inc., GlaxoSmithKline, Hoffmann-La Roche, Merck Sharp & Dohme, Hutchison Medipharma Limited, Genome & Company, Minneamrita Therapeutics LLC, Suzhou Suncadia Biopharmaceuticals Co., Ltd., MacroGenics, ALX Oncology Inc., Codiak BioSciences, Turning Point Therapeutics, Inc., TCRx Therapeutics, InxMed (Shanghai) Co., Ltd., Imugene Limited, SOTIO Biotech, CARsgen Therapeutics Co., Ltd., Zymeworks Inc., NextCure, Inc., Phanes Therapeutics, Pieris Pharmaceuticals, Inc., Athenex, Inc., Curis, Inc., Qurient Co., Ltd., Acepodia Biotech, Inc., Sichuan Baili Pharmaceutical Co., Ltd., Tarus Therapeutics, Inc., Lumicell, Inc., Legend Biotech,Cue Biopharma, TORL Biotherapeutics, LLC, OBI Pharma, Inc, Astellas Pharma, HiberCell, Inc., Celon Pharma SA, Linnaeus Therapeutics, Inc., Inspirna, Inc., Klus Pharma Inc., Genzada Pharmaceuticals, Shanghai PerHum Therapeutics, VM Oncology, LLC, Immunomic Therapeutics, Peptron, and others. Key Gastric Cancer Pipeline Therapies: Avelumab, BBI608, Camrelizumab, Catumaxomab, RAPA-201, SHR-1210, Amivantamab, Atezolizumab, Bevacizumab, Cabozantinib, Cinrebafusp alfa, Crizotinib, DKN-01, DP303c, Eflornithine, EP0057, Epacadostat, FLX475, Futibatinib, GEN-001, HLX07, HLX22, Infigratinib, KH903, Lenvatinib, Masitinib, MAX-40279, MRG002, MRG003, Niraparib, Savolitinib, Minnelide, SHR-1701, Margetuximab, Bemarituzumab, Evorpacept, Lenvatinib, CDK-004, TPX-0022, TCRx_T Cells, IN10018, IMU-131, SOT102, CT041, AB011, Zanidatamab, NC410, PT 886, PRS-343, Oraxol, CA-4948, Q702, ACE1702, SI-B001, TT-4, LUM015, LB 1908, CUE-102, TORL-2-307-MAB, OBI-833/OBI-821, ASP2138, NC410, SO-C101, HC-5404-FU, CPL304110, LNS8801, RGX-202-01, A166, GZ17-6.02, HMPL-453, CCT303-406, VMD-928, ITI 4000, PAb 001, and others. Dive deep into rich insights for new drugs for gastric cancer treatment; visit @ Gastric Cancer Medications Table of Contents For further information on the gastric cancer pipeline therapeutics, reach out @ Gastric Cancer Drug Treatment Related Reports Gastric Cancer Epidemiology Forecast Gastric Cancer Epidemiology Forecast – 2032 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, and the gastric cancer epidemiology trends. Gastric Cancer Market Gastric Cancer Market Insight, Epidemiology, and Market Forecast – 2032 report delivers an in-depth understanding of the market trends, market drivers, market barriers, and key gastric cancer companies, including CSPC ZhongQi Pharmaceutical, Ellipses Pharma, Amgen, Hanmi Pharmaceutical, Taiho Oncology, Inc., Shanghai Henlius Biotech, among others. HER2+ Gastric Cancer Market HER2+ Gastric Cancer Market Insight, Epidemiology, and Market Forecast – 2032 report delivers an in-depth understanding of the market trends, market drivers, market barriers, and key HER2+ gastric cancer companies, including Pieris Pharmaceuticals, BioInvent International, Bellicum Pharmaceuticals, Mersana Therapeutics, Acepodia Biotech, Inc., Klus Pharma Inc, among others. HER2+ Gastric Cancer Pipeline HER2+ Gastric Cancer Pipeline Insight – 2022 report provides comprehensive insights about the pipeline landscape, including clinical and non-clinical stage products, and the key HER2+ gastric cancer companies, including Pieris Pharmaceuticals, BioInvent International, Bellicum Pharmaceuticals, Mersana Therapeutics, Acepodia Biotech, Inc., Klus Pharma Inc, among others. HER2+ Gastric Cancer Epidemiology HER2+ Gastric Cancer Epidemiology Forecast – 2032 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, and the HER2+ gastric cancer epidemiology trends. Other Trending Oncology Reports Follicular lymphoma | Indolent lymphoma | Severe Toxicities In Lymphoma | Marginal Zone Lymphoma | Vulvar Squamous Cell Carcinoma | Cholangiocarcinoma | Metastatic Cutaneous Squamous cell Carcinoma | Nasopharyngeal Carcinoma | Ductal Carcinoma in Situ | Oncolytic Virus Cancer Therapy | Cancer Cachexia | Intratumoral Cancer Therapies | Brain Cancer Related Cases Studies Competitive Intelligence Market Assessment Product Assessment Epidemiology Assessment Related Healthcare Services Healthcare Business Consulting Healthcare Competitive Intelligence Services Healthcare Asset Prioritization Services About DelveInsight DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. Connect with us at LinkedIn Contact Us Shruti Thakur [email protected] +1(919)321-6187 Logo: SOURCE DelveInsight Business Research, LLP

ImmunotherapyOrphan DrugDrug Approval

100 Deals associated with Napabucasin

External Link

KEGG	Wiki	ATC	Drug Bank
D10717	-	-	DB12155

R&D Status

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Advanced Gastroesophageal Junction Adenocarcinoma	Discovery	South Korea	Sumitomo Pharma America, Inc.	01 Oct 2014
Advanced Gastroesophageal Junction Adenocarcinoma	Discovery	Bulgaria	Sumitomo Pharma America, Inc.	01 Oct 2014
Advanced Gastroesophageal Junction Adenocarcinoma	Discovery	Hungary	Sumitomo Pharma America, Inc.	01 Oct 2014
Advanced Gastroesophageal Junction Adenocarcinoma	Discovery	Romania	Sumitomo Pharma America, Inc.	01 Oct 2014
Advanced Gastroesophageal Junction Adenocarcinoma	Discovery	Canada	Sumitomo Pharma America, Inc.	01 Oct 2014
Advanced Gastroesophageal Junction Adenocarcinoma	Discovery	Lithuania	Sumitomo Pharma America, Inc.	01 Oct 2014
Advanced Gastroesophageal Junction Adenocarcinoma	Discovery	Poland	Sumitomo Pharma America, Inc.	01 Oct 2014
Advanced Colorectal Adenocarcinoma	Discovery	Japan	Sumitomo Pharma America, Inc.	10 May 2013
Advanced Colorectal Adenocarcinoma	Discovery	Australia	Sumitomo Pharma America, Inc.	10 May 2013
Advanced Colorectal Adenocarcinoma	Discovery	Canada	Sumitomo Pharma America, Inc.	10 May 2013

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT02358395 (Pubmed)	Phase 1	Unresectable Hepatocellular Carcinoma	6	Napabucasin (480 mg/day) plus Sorafenib (800 mg/day)	(aqvnldsvmg) = stable disease sqrhnepybb (xicthwxzyg )	-	15 May 2023
NCT01325441 (CTgov)	Phase 1/2	Neoplasms \| HR-positive/HER2-low Solid Tumors	565	Paclitaxel+Napabucasin (Napabucasin 200mg BID Plus Paclitaxel)	rsinlpkvwz(pwknjwjjht) = wgszyrrgan tpymghazuc (hjfgwyopgh, fswrsbdwpv - ogqwvkowpd) View more	-	03 Feb 2023
				Paclitaxel+Napabucasin (Napabucasin 240mg BID Plus Paclitaxel)	rsinlpkvwz(pwknjwjjht) = phlksvpzvj tpymghazuc (hjfgwyopgh, fqlokvshhx - ticocvjqum) View more
NCT02753127 (CanStem303C, CTgov)	Phase 3	Metastatic Colorectal Carcinoma	1,253	Bevacizumab+Napabucasin (Napabucasin + FOLFIRI ± Bevacizumab)	vjoespozsn(osqomwnrwg) = eainwvmjen zjrflrvsgh (hvmebinmvi, metvxpbxur - udtcrfidph) View more	-	26 Apr 2022
				Bevacizumab (FOLFIRI ± Bevacizumab)	vjoespozsn(osqomwnrwg) = cntzuidvwq zjrflrvsgh (hvmebinmvi, nqmuotmiwt - oypcueyspa) View more
NCT02641873 (Pubmed \| Int J Clin Oncol) Manual	Phase 1	Metastatic Colorectal Carcinoma	4	bevacizumab+fluorouracil+leucovorin+irinotecan+napabucasin	(jsatxtywyn) = All four patients experienced diarrhoea and decreased appetite (considered napabucasin-related in four and two patients, respectively), and three patients experienced neutrophil count decreased iaafzcneov (qnupnsylxr )	Positive	01 Nov 2021
NCT02347917 (CTgov)	Phase 1/2	Malignant Pleural Mesothelioma \| Non-Small Cell Lung Cancer	28	Pem+CDDP+BBI608 (MPM or NSCLC: BBI608 + Pem + CDDP (Phase 1 Part))	ufzdfblphv(cnizwkoher) = vpkvsbvatl ufelpvbexe (bgxyjapfeg, uxbvehnade - vwsubgkmvz) View more	-	01 Oct 2021
				Pem+CDDP+BBI608 (MPM: BBI608 + Pem + CDDP (Phase 2 Part))	fkfnhovyrt(ffeyqchnrd) = hcykjazvzq qbqgncmbfh (xuaewmmaqo, qoypcigkka - qzjteuioie) View more
NCT02024607 (CTgov)	Phase 1/2	Gastrointestinal Neoplasms	495	FOLFOX6+Napabucasin (Napabucasin Plus FOLFOX6)	bflboplvbq(ibftopphsy) = ptxnlpgbjd sewtcmwsuf (abdozjfccs, otpkloxzqa - elpvgmkxpa) View more	-	20 Sep 2021
				Bevacizumab+Napabucasin (Napabucasin Plus FOLFOX6 Plus Bevacizumab)	bflboplvbq(ibftopphsy) = zvtktyeoiu sewtcmwsuf (abdozjfccs, hxmshvyisp - etyzpikbmn) View more
NCT02993731 (CanStem111P, ESMO 12021 \| ESMO 22021) Manual	Phase 3	Pancreatic adenocarcinoma metastatic First line	-	nab-paclitaxel+gemcitabine+napabucasin (GSP: napabucasin)	(nsowphrluf) = obglxgqwrp aepuwqtgjf (upzezgmmyr ) View more	Negative	16 Sep 2021
				nab-paclitaxel+gemcitabine (GSP: CTL)	(nsowphrluf) = amljawqguj aepuwqtgjf (upzezgmmyr ) View more
NCT01776307 (BBI608-224, CTgov)	Phase 2	Advanced Colorectal Adenocarcinoma	200	Cetuximab+Napabucasin (Napabucasin Plus Cetuximab)	(ktrobidxjl) = srtudifqry nflatvffrk (qtxshvrgbs, cyqzkvqtvc - daenblatij) View more	-	18 Jun 2021
				Panitumumab+Napabucasin (Napabucasin Plus Panitumumab)	(ktrobidxjl) = wcgwamfuol nflatvffrk (qtxshvrgbs, zmkqleqxej - cynrietabx) View more
NCT02993731 (CanStem111P, CTgov)	Phase 3	Pancreatic adenocarcinoma metastatic \| Pancreatic Ductal Carcinoma \| Metastatic Pancreatic Ductal Adenocarcinoma	1,134	Nab-paclitaxel+Gemcitabine+Napabucasin (Napabucasin Plus Nab-paclitaxel With Gemcitabine)	(tpiuglyzuf) = nzcoeowofc gtzjycbvfn (wqslhsrqwl, hfjtarvinf - bqqhdeedwb) View more	-	10 Jun 2021
				Nab-paclitaxel+Gemcitabine (Nab-paclitaxel With Gemcitabine)	(tpiuglyzuf) = twzibeafdd gtzjycbvfn (wqslhsrqwl, ocjgjxthzs - hjpdfpznkv) View more
NCT02178956 (BRIGHTER, CTgov)	Phase 3	Gastrooesophageal junction cancer \| Advanced Gastroesophageal Junction Adenocarcinoma	714	Paclitaxel+Napabucasin (Napabucasin + Paclitaxel)	(rhismmtdzm) = xsxiazbftn kldgyrtvkk (vjaltvjrjw, rznsfunffn - pbfkbofffl) View more	-	10 May 2021
				Placebo+Paclitaxel (Placebo + Paclitaxel)	(rhismmtdzm) = igfwgnueqe kldgyrtvkk (vjaltvjrjw, ijlcazvsnq - vbyucamfwe) View more

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