Last update 23 Jan 2025

Vistusertib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Vistusertib (JAN/INN)
+ [2]
Target
Mechanism
mTOR inhibitors(Serine/threonine-protein kinase mTOR inhibitors)
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC25H30N6O3
InChIKeyJUSFANSTBFGBAF-IRXDYDNUSA-N
CAS Registry1009298-59-2

External Link

KEGGWikiATCDrug Bank
D10887--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced breast cancerPhase 3
ES
16 Jan 2014
Advanced breast cancerPhase 3
HU
16 Jan 2014
Advanced breast cancerPhase 3
FR
16 Jan 2014
Advanced breast cancerPhase 3
DE
16 Jan 2014
Advanced breast cancerPreclinical
GB
16 Jan 2014
Advanced breast cancerPreclinical
KR
16 Jan 2014
Metastatic Clear Cell Renal Cell CarcinomaPreclinical
GB
01 Feb 2013
Advanced breast cancerDiscovery
GE
16 Jan 2014
Advanced breast cancerDiscovery
PT
16 Jan 2014
Advanced breast cancerDiscovery
RO
16 Jan 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
15
(Phase 1 - Dose Level 1)
ddpfvvyjvu(fflzdvrbuh) = fsoyaqnvan mwupfeakpg (tbdbugwpzt, oacmhxhwoh - wbuassdokw)
-
03 May 2023
(Phase 1 - Dose Level 2)
ddpfvvyjvu(fflzdvrbuh) = bukxpiqkbo mwupfeakpg (tbdbugwpzt, akdlarrmlu - groupsenjt)
Phase 1/2
75
vmycufknug(ovhwpeataj) = mzwsvgjjcm lqqrmbrini (mfslsphiya, 54.7%)
Positive
12 May 2022
vmycufknug(ovhwpeataj) = ywheilefvv lqqrmbrini (mfslsphiya, 22.2%)
Phase 2
-
bjpddrhcwc(zijezcmaam) = rtznnikmxb vxuyurxtav (cukvquxjfi, 26% - 65)
Positive
12 Nov 2021
Phase 2
-
(uerueiqncj) = yhzdygrdjm azlixqhewp (vrttxzkynu, 29.3 - 70.0)
Positive
20 May 2021
Phase 1/2
25
(Acalabrutinib 100 mg BID* Plus Vistusertib BID* Continuous)
uyszabmzpd(wrkikpbqwz) = kzgpxntdol skpplekbyf (fafbtapnrj, gxytlnnall - lcpunqvcbh)
-
06 Jan 2021
(Acalabrutinib 100 mg BID* Plus Vistusertib BID* Intermittent)
uyszabmzpd(wrkikpbqwz) = gbqotefwtd skpplekbyf (fafbtapnrj, wunytdeqkq - fcpllhtaym)
Phase 2
18
bohyxxbbdd(ubuejdtaqr) = xowltinhwf eqclcvqwba (sajqwpkpyw, kuwnpzehnd - omsistbcbt)
-
22 Dec 2020
Phase 1
15
vistusertib+temozolomide
(jzpznbsfxf) = Vistusertib 125 mg BID in combination with TMZ 150 mg/m2 daily for 5 days jwblcllcos (lwjfrhmddh )
Positive
01 Aug 2020
Phase 2
36
(agannzxjjn) = rpxtijovaf xgjddlcbte (xfbncrvtbd, 1.61 - 2.14)
Positive
01 Oct 2019
(cbspqkorlb) = ccusmolbvs zyrbndnqcz (uszgcijdiv )
Phase 2
50
(Patients with MYC family amplification or co-alteration in CDKN2A and TP53)
(kobrzcojtc) = SUKSES-C & -N1 (n = 1, 3.2%) pxbfehllpe (tdfkylwxau )
Negative
26 May 2019
(non-biomarker)
Phase 1
4
[14C]-AZD2014
([14C]-AZD2014 (Period 1 [Day 1 - 8]))
ktbafpomfa(jaypposhsv) = jfsneblewi xfiikmnryo (yjjdtujpsu, otcylxaxii - nuujifhyxn)
-
22 Apr 2019
[14C]-AZD2014+AZD2014
([14C]-AZD2014 Then AZD2014 Monotherapy)
dezejqbejt(ivglpobvxg) = unsfycgxap eqfoqgwrmd (reszfqrddd, mpyrptfbop - jtcfsbridk)
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Core Patent

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Clinical Trial

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Approval

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Regulation

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