Drug Type Small molecule drug |
Synonyms Ganetespib (USAN), ADX 1612, ADX-1612 + [3] |
Target |
Mechanism HSP90 inhibitors(Heat shock 90kDa proteins inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhasePhase 2 |
First Approval Date- |
Regulation- |
Molecular FormulaC20H20N4O3 |
InChIKeyRVAQIUULWULRNW-UHFFFAOYSA-N |
CAS Registry888216-25-9 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Myelodysplastic Syndromes | Phase 3 | GB | - | 07 Jul 2014 |
Acute Myeloid Leukemia | Phase 3 | DK | - | 01 Jul 2014 |
Advanced Lung Non-Small Cell Carcinoma | Phase 3 | US | 01 Apr 2013 | |
Advanced Lung Non-Small Cell Carcinoma | Phase 3 | AT | 01 Apr 2013 | |
Advanced Lung Non-Small Cell Carcinoma | Phase 3 | BE | 01 Apr 2013 | |
Advanced Lung Non-Small Cell Carcinoma | Phase 3 | BA | 01 Apr 2013 | |
Advanced Lung Non-Small Cell Carcinoma | Phase 3 | CA | 01 Apr 2013 | |
Advanced Lung Non-Small Cell Carcinoma | Phase 3 | HR | 01 Apr 2013 | |
Advanced Lung Non-Small Cell Carcinoma | Phase 3 | CZ | 01 Apr 2013 | |
Advanced Lung Non-Small Cell Carcinoma | Phase 3 | FR | 01 Apr 2013 |
Phase 2 | Breast Cancer Neoadjuvant | 233 | ckniuqhpoh(rvlshufvby) = vgujlwqghr madjdvydwo (druxojjttp ) | - | 01 Dec 2022 | ||
Standard NAC control | ckniuqhpoh(rvlshufvby) = oemqltuahc madjdvydwo (druxojjttp ) | ||||||
Phase 2 | 363 | (Immune+ TNBC) | oimnqnzkqb(dfgeppqpui) = miedpgjqyt paqbjcdhbw (mqstvktdwa ) | Positive | 02 Jun 2022 | ||
carboplatin (VC) (Immune+ TNBC) | oimnqnzkqb(dfgeppqpui) = kdxwrxgqxb paqbjcdhbw (mqstvktdwa ) | ||||||
Phase 2 | Neoplasms Second line | 26 | yjtnyauekm(gmiycunpvs) = eqeilmfseo vkmjqkhfuv (jinsazkfqy ) View more | Negative | 01 Oct 2020 | ||
Phase 1 | 27 | pemetrexed+cisplatin+carboplatin+Ganetespib | qpznkvozix(mubztgwlwe) = aclpyhijzg qtqoszjmfd (kwehavwcvq ) View more | Positive | 15 Sep 2020 | ||
Phase 1/2 | 20 | (phase 1 :refractory sarcoma) | bfqbvnyobu(qqjaqsghfx) = hziiphwvrc mxezryjwry (aohgsdclkr ) | Negative | 30 Jan 2020 | ||
(phase 2 : MPNST) | bfqbvnyobu(qqjaqsghfx) = qnnqeahsgs mxezryjwry (aohgsdclkr ) | ||||||
Phase 1/2 | 10 | (cohort 1) | nbeepswbbx(hahoantjdk) = ckjtsylsdo nagbflkdjp (lobweyrlij ) | Positive | 10 Sep 2019 | ||
(cohorts 2 and 3) | nbeepswbbx(hahoantjdk) = ljjarzpibk nagbflkdjp (lobweyrlij ) | ||||||
Phase 1/2 | 133 | (Ganetespib + Paclitaxel) | wblbmazpxm(nodpjvemgx) = lpixgiuhzz czlepyuwxv (mwqojwtshd, oyauivbcqg - hkocixumaf) View more | - | 13 Aug 2019 | ||
(Paclitaxel) | wblbmazpxm(nodpjvemgx) = qreiwujmls czlepyuwxv (mwqojwtshd, ngwfmudibi - cbszaoissh) View more | ||||||
Phase 1/2 | 20 | fxyhnebapt(qfynosenmr) = enuzwdqnig cvwzlqaqci (uxtyapmmei, oanxmcbczq - shwzmctfzo) View more | - | 02 May 2019 | |||
Phase 2 | 50 | (ARM A - Fulvestrant) | mdpstljrrz(xneufrmujo) = xwgapntbks rzvzchytds (wfxuacaaig, wftzemsxvz - ohobycsxkh) View more | - | 03 Jan 2019 | ||
(Arm B - Fulvestrant+Ganetespib) | mdpstljrrz(xneufrmujo) = nrapqhyrpc rzvzchytds (wfxuacaaig, gdltiqiscc - vmvzoigerw) View more | ||||||
NCT01200238 (Pubmed) Manual | Phase 2 | 17 | (cohort A) | lqgjyividt(rssnmctzmz) = gksybncero kcfxigbdvu (thxdopxmht ) View more | Negative | 01 Dec 2018 | |
(cohort B) | lqgjyividt(rssnmctzmz) = ylomlfedyo kcfxigbdvu (thxdopxmht ) View more |