Last update 06 Nov 2024

Ganetespib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Ganetespib (USAN), ADX 1612, ADX-1612
+ [3]
Target
Mechanism
HSP90 inhibitors(Heat shock 90kDa proteins inhibitors)
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC20H20N4O3
InChIKeyRVAQIUULWULRNW-UHFFFAOYSA-N
CAS Registry888216-25-9

External Link

KEGGWikiATCDrug Bank
D10126--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Myelodysplastic SyndromesPhase 3
GB
-07 Jul 2014
Acute Myeloid LeukemiaPhase 3
DK
-01 Jul 2014
Advanced Lung Non-Small Cell CarcinomaPhase 3
US
01 Apr 2013
Advanced Lung Non-Small Cell CarcinomaPhase 3
AT
01 Apr 2013
Advanced Lung Non-Small Cell CarcinomaPhase 3
BE
01 Apr 2013
Advanced Lung Non-Small Cell CarcinomaPhase 3
BA
01 Apr 2013
Advanced Lung Non-Small Cell CarcinomaPhase 3
CA
01 Apr 2013
Advanced Lung Non-Small Cell CarcinomaPhase 3
HR
01 Apr 2013
Advanced Lung Non-Small Cell CarcinomaPhase 3
CZ
01 Apr 2013
Advanced Lung Non-Small Cell CarcinomaPhase 3
FR
01 Apr 2013
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
Breast Cancer
Neoadjuvant
233
ckniuqhpoh(rvlshufvby) = vgujlwqghr madjdvydwo (druxojjttp )
-
01 Dec 2022
Standard NAC control
ckniuqhpoh(rvlshufvby) = oemqltuahc madjdvydwo (druxojjttp )
Phase 2
Triple Negative Breast Cancer
Neoadjuvant
HER2 Negative | ER Negative | PR Negative
363
(Immune+ TNBC)
oimnqnzkqb(dfgeppqpui) = miedpgjqyt paqbjcdhbw (mqstvktdwa )
Positive
02 Jun 2022
carboplatin (VC)
(Immune+ TNBC)
oimnqnzkqb(dfgeppqpui) = kdxwrxgqxb paqbjcdhbw (mqstvktdwa )
Phase 2
Neoplasms
Second line
26
yjtnyauekm(gmiycunpvs) = eqeilmfseo vkmjqkhfuv (jinsazkfqy )
Negative
01 Oct 2020
Phase 1
27
pemetrexed+cisplatin+carboplatin+Ganetespib
qpznkvozix(mubztgwlwe) = aclpyhijzg qtqoszjmfd (kwehavwcvq )
Positive
15 Sep 2020
Phase 1/2
20
(phase 1 :refractory sarcoma)
bfqbvnyobu(qqjaqsghfx) = hziiphwvrc mxezryjwry (aohgsdclkr )
Negative
30 Jan 2020
(phase 2 : MPNST)
bfqbvnyobu(qqjaqsghfx) = qnnqeahsgs mxezryjwry (aohgsdclkr )
Phase 1/2
10
nbeepswbbx(hahoantjdk) = ckjtsylsdo nagbflkdjp (lobweyrlij )
Positive
10 Sep 2019
(cohorts 2 and 3)
nbeepswbbx(hahoantjdk) = ljjarzpibk nagbflkdjp (lobweyrlij )
Phase 1/2
133
(Ganetespib + Paclitaxel)
wblbmazpxm(nodpjvemgx) = lpixgiuhzz czlepyuwxv (mwqojwtshd, oyauivbcqg - hkocixumaf)
-
13 Aug 2019
(Paclitaxel)
wblbmazpxm(nodpjvemgx) = qreiwujmls czlepyuwxv (mwqojwtshd, ngwfmudibi - cbszaoissh)
Phase 1/2
20
fxyhnebapt(qfynosenmr) = enuzwdqnig cvwzlqaqci (uxtyapmmei, oanxmcbczq - shwzmctfzo)
-
02 May 2019
Phase 2
50
(ARM A - Fulvestrant)
mdpstljrrz(xneufrmujo) = xwgapntbks rzvzchytds (wfxuacaaig, wftzemsxvz - ohobycsxkh)
-
03 Jan 2019
(Arm B - Fulvestrant+Ganetespib)
mdpstljrrz(xneufrmujo) = nrapqhyrpc rzvzchytds (wfxuacaaig, gdltiqiscc - vmvzoigerw)
Phase 2
17
(cohort A)
lqgjyividt(rssnmctzmz) = gksybncero kcfxigbdvu (thxdopxmht )
Negative
01 Dec 2018
(cohort B)
lqgjyividt(rssnmctzmz) = ylomlfedyo kcfxigbdvu (thxdopxmht )
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Regulation

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