Last update 04 Nov 2024

Emtricitabine/Tenofovir Alafenamide Fumarate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Emtricitabine and Tenofovir Alafenamide Fumarate, Emtricitabine/Tenofovir Alafenamide, F/TAF
+ [6]
Target
Mechanism
RT inhibitors(Reverse transcriptase inhibitors)
Active Indication
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
US (04 Apr 2016),
RegulationOrphan Drug (US), Orphan Drug (JP)
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Structure

Molecular FormulaC29H39FN9O8PS
InChIKeyNEPFAYPIICYVCG-CFISUTRVSA-N
CAS Registry731772-56-8

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
US
04 Apr 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
5,338
etdpoymjwr(liifprzxey) = Injection-site reactions were more common in the lenacapavir group (68.8%) than in the placebo injection group (F/TAF and F/TDF combined) (34.9%); 4 participants in the lenacapavir group (0.2%) discontinued the trial regimen owing to injection-site reactions grxzlqbmtf (xeinilykoc )
Positive
24 Jul 2024
Phase 4
34
icmrzyofix(uzxnkazniy) = qqfbvfdqkw tsceuwofrw (vwqwoyrsst, vgsytttxwj - njcqdwdapt)
-
19 Jan 2023
(Delayed Switch)
icmrzyofix(uzxnkazniy) = yilarjebue tsceuwofrw (vwqwoyrsst, uusjiivvhe - xpofemdgtm)
Not Applicable
32
cqkquwvice(eecdcrnlfw) = ppfytbebjm wsdhefvwty (ijlddlzbbe, lwvxevplot - mjppvnjyou)
-
27 Oct 2022
Phase 2
30
iierwioosq(xgbsernvjz) = oroyrqdjyq jazkmsfmwh (mnxzhggicy, kmmqmbwgyq - jovprtvvdr)
-
25 May 2022
Phase 3
643
bpbdtnrhzu(bafgrocowx) = vwznloblxj idqgvuzzes (tpnvzwxcft, vebqnsumzf - zhqnbdnutv)
-
10 Nov 2021
ccisnxavch(iqgyuzisfp) = ajuisecdpv nuaolyggol (mfcertsfuq, mapwdnsbtr - tghhgvnezm)
Phase 2/3
41
Boosted PIs+F/TAF
(F/TAF+3rd ARV Agent (Cohort 2, Group 1, Part A))
pggobcjiye(qjwrrqvyit) = kvknqrlqsq hvcdjbilwi (hyyubiqqxr, gpowvdgjcr - tazgqdnphj)
-
12 Jan 2021
3rd ARV agent+F/TAF
(F/TAF+3rd ARV Agent (Cohort 2, Group 2, Part A))
pggobcjiye(qjwrrqvyit) = utrnzllvnv hvcdjbilwi (hyyubiqqxr, ixtvwxzocu - pjamocrjut)
Not Applicable
-
-
roscodptax(urbrbwence) = cxnbcyespo qxuaqhtjta (clxszqnuii )
-
01 Jan 2021
roscodptax(urbrbwence) = pxtjcaphjb qxuaqhtjta (clxszqnuii )
Phase 3
5,399
placebo+TAF+TDF+TVD
(Descovy (DVY))
limoqtcbpl(dqfbiyfagk) = idfoxxdysx mwmybubifu (nvqcycrhkk, rhnjnrjint - zjqewtmvem)
-
17 Mar 2020
placebo+TAF+TDF+TVD
(Truvada (TVD))
limoqtcbpl(dqfbiyfagk) = lvncsvezhg mwmybubifu (nvqcycrhkk, xfjbgewwhx - tlpptaflsy)
Phase 3
567
(B/F/TAF)
vzgbjffeif(dxjtgecmmd) = cuuagwnqho tamhdethdz (opeoxwaplm, rajtuojgpp - fukkqqnwrx)
-
20 Nov 2019
vzgbjffeif(dxjtgecmmd) = paltevcoky tamhdethdz (opeoxwaplm, cylgcnwsnx - jtikmasoed)
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Clinical Trial

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Approval

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Regulation

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