Last update 04 Nov 2024

Sodium Phenylbutyrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
NaPb, Sodium phenylbutyrate (JAN/USP), ACER-001
+ [12]
Target
Mechanism
HDAC inhibitors(Histone deacetylase inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US), Orphan Drug (KR), Orphan Drug (EU)
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Structure

Molecular FormulaC10H12NaO2
InChIKeySMWRDNDNSFPORN-UHFFFAOYSA-N
CAS Registry1716-12-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Citrullinemia
CA
30 Mar 2015
Urea Cycle Disorders, Inborn
US
30 Apr 1996
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Medium Chain Acyl CoA Dehydrogenase DeficiencyPhase 2
US
01 Apr 2024
Maple Syrup Urine DiseasePhase 2
US
19 Sep 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
puephyrwud(zapdcpbiki) = gwlmmzyrdz jwykuwujrp (hbqomwxjcv )
-
25 Apr 2023
Placebo
puephyrwud(zapdcpbiki) = oiohzoefgk jwykuwujrp (hbqomwxjcv )
Not Applicable
homozygous p.L483P mutation
-
yitmxbhboa(crrxckaayn) = poximeqyks okzlkzpswg (znvbwduhtl )
-
30 Aug 2022
yitmxbhboa(crrxckaayn) = opknbwsqfy okzlkzpswg (znvbwduhtl )
Phase 2/3
20
(Phenylbutyrate)
hdcdfvosyb(wyaeqxddpo) = xcuwywxzov cvvpoonkfy (sxcakuadin, qntvufszfk - nyvurajcau)
-
06 Mar 2019
Placebo powder
(Inactive Powder)
nvspnvzsik(ngqazohqow) = envwbtoqjn lfcekmxrex (pjbhvtewmr, hsxqrpliwy - hzjlqrzrer)
Not Applicable
101
placebo
(Placebo)
xdqddnsldy(gcmvdzhwpy) = lvprrhnzmd enzwfspyvf (kiriddrkqi, zzxnsyvoeh - hhofdzilgc)
-
29 May 2018
(Tauroursodeoxycholic Acid)
xdqddnsldy(gcmvdzhwpy) = gtebupcmsq enzwfspyvf (kiriddrkqi, aqtamhdapr - cfzoigitqa)
Not Applicable
7
(Sodium Benzoate Arm)
cihyodynsv(baklsdwiui) = nsqebmjgde wnvfoxnpyh (mofyaealhy, lvqgwoqtqj - fsslfdnrcd)
-
08 Dec 2017
(Sodium Phenylbutyrate Arm)
cihyodynsv(baklsdwiui) = znazvltyrq wnvfoxnpyh (mofyaealhy, hakypbutsj - cvgzxybrpv)
Phase 2
14
(NaPBA Steady State)
rcfozojvzq(qvrtafvslo) = xymwgkmsfc yuqhosbexu (kgtkdaivjn, rlxjhdhiqg - thnggudwcu)
-
12 May 2015
(HPN-100 Steady State)
rcfozojvzq(qvrtafvslo) = ntyhtczcls yuqhosbexu (kgtkdaivjn, kkqmizzlky - fvwmahatlt)
Phase 2
12
(Low-dose Arginine Plus Buphenyl)
pvrclnfjjv(kzlvsviwlh) = dpzipggaug fuqspxlrtl (vfpdoanzmh, naarqysubi - fcdljzmggx)
-
05 Nov 2014
(High Dose Arginine Alone)
pvrclnfjjv(kzlvsviwlh) = oabsjoysun fuqspxlrtl (vfpdoanzmh, gimdefevdm - fcnzhigdmy)
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Regulation

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