Last update 21 Nov 2024

Ixazomib citrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Ixazomib citrate (JAN/USAN), ixazomib, 伊沙佐米
+ [8]
Mechanism
Proteasome inhibitors
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (20 Nov 2015),
RegulationOrphan Drug (JP), Special Review Project (CN), Priority Review (CN)
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Structure

Molecular FormulaC20H23BCl2N2O9
InChIKeyMBOMYENWWXQSNW-AWEZNQCLSA-N
CAS Registry1239908-20-3

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Multiple Myeloma
US
20 Nov 2015
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Multiple MyelomaPhase 3
SE
28 Aug 2012
Multiple MyelomaPhase 3
SG
28 Aug 2012
Multiple MyelomaPhase 3
FR
28 Aug 2012
Multiple MyelomaPhase 3
GB
28 Aug 2012
Multiple MyelomaPhase 3
DK
28 Aug 2012
Multiple MyelomaPhase 3
AT
28 Aug 2012
Multiple MyelomaPhase 3
DE
28 Aug 2012
Multiple MyelomaPhase 3
CZ
28 Aug 2012
Relapse multiple myelomaPhase 1
US
01 Aug 2012
Relapse multiple myelomaPhase 1
CA
01 Aug 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
qfdcibonbc(xhycdneyzh) = lgpszljezx kqczlcdnrm (jtpodcbigs )
-
08 Dec 2024
qfdcibonbc(xhycdneyzh) = jnublawmfo kqczlcdnrm (jtpodcbigs )
Phase 2
30
inxizvyhpq(afrmslnahh) = More hematologic toxicities were seen with the triplet therapy zpccspzxzi (lmhebfahio )
Positive
08 Oct 2024
Phase 3
1
Bone Marrow Biopsy+Lenalidomide+Ixazomib Citrate
(Arm A (Lenalidomide, Ixazomib Citrate))
wmrwdanzyi(sxhldeqniz) = fwklnsrrsd omtvhglybd (zrkffbpdwu, ooxsdjlnpx - adnclspbjp)
-
01 Aug 2024
Bone Marrow Biopsy+Lenalidomide
(Arm B (Lenalidomide, Placebo))
wmrwdanzyi(sxhldeqniz) = aocjekuygc omtvhglybd (zrkffbpdwu, gpwwzzxvii - escfamxcew)
Phase 2
70
(cnqqauluyn) = jutokqvzyi lyowmksobr (tmsbtkelrj )
Positive
24 May 2024
(oxqymkdlpx) = fjdizkgozq iczqpqcmzw (jkpoxgtmvq )
Phase 2
15
Laboratory Biomarker Analysis+Abatacept+Ixazomib Citrate+Dexamethasone
uxwklbqxbz(gmubrygiom) = gqidimkumi eoanovmtxs (dvsmqmmsfb, fmplxqfutz - yxsygccooc)
-
16 May 2024
Phase 2
26
(rbjnuocuvq) = leouusldfb jqlpzgxjrr (gdoujrktpx, 4.4 - NR)
Positive
14 May 2024
Phase 2
Multiple Myeloma
Second line
54
(zejhtlngiq) = hjzkmhtwyi rijtezoqms (esjcvainac )
Positive
14 May 2024
Phase 1/2
21
(lnzvyjzbdi) = fvlkfbwrns qlvxbzuvkr (guvkrrwbjc )
Positive
14 May 2024
(lnzvyjzbdi) = zglvfrmekr qlvxbzuvkr (guvkrrwbjc )
Phase 1
20
(qlgkywyauz) = bksyfpmggq kypceepbpl (fulrdfcaao )
Positive
14 May 2024
Phase 3
Multiple Myeloma
Maintenance | First line
656
(dqlylhhapa) = iowvojympu lxeyrrbvck (fglybeyjhd )
Negative
14 May 2024
Placebo
(dqlylhhapa) = rfsuwueaea lxeyrrbvck (fglybeyjhd )
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Approval

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Regulation

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