Last update 04 Nov 2024

Ixazomib citrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
ixazomib, Ixazomib citrate (JAN/USAN), 伊沙佐米
+ [7]
Mechanism
Proteasome inhibitors
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (20 Nov 2015),
RegulationOrphan Drug (US), Orphan Drug (KR), Special Review Project (CN), Priority Review (CN), Orphan Drug (JP)
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Structure

Molecular FormulaC20H23BCl2N2O9
InChIKeyMBOMYENWWXQSNW-AWEZNQCLSA-N
CAS Registry1239908-20-3

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Multiple Myeloma
US
20 Nov 2015
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
PlasmacytomaPhase 3
US
01 Dec 2015
PlasmacytomaPhase 3
US
01 Dec 2015
Spondylocarpotarsal SynostosisPhase 3
US
17 Mar 2015
Spondylocarpotarsal SynostosisPhase 3
US
17 Mar 2015
Spondylocarpotarsal SynostosisPhase 3
US
17 Mar 2015
Spondylocarpotarsal SynostosisPhase 3
JP
17 Mar 2015
Spondylocarpotarsal SynostosisPhase 3
JP
17 Mar 2015
Spondylocarpotarsal SynostosisPhase 3
JP
17 Mar 2015
Spondylocarpotarsal SynostosisPhase 3
AR
17 Mar 2015
Spondylocarpotarsal SynostosisPhase 3
AR
17 Mar 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
30
txpzqeokld(lodtoxjccd) = More hematologic toxicities were seen with the triplet therapy vujektfsey (kjkcgvmrsz )
Positive
08 Oct 2024
Phase 3
1
Bone Marrow Biopsy+Lenalidomide+Ixazomib Citrate
(Arm A (Lenalidomide, Ixazomib Citrate))
ttdgvhhgug(ghuahwylsp) = exfmfvhjpr oavzbznvgf (icowpsxzag, mcmjiqjrtq - shdcidrynd)
-
01 Aug 2024
Bone Marrow Biopsy+Lenalidomide
(Arm B (Lenalidomide, Placebo))
ttdgvhhgug(ghuahwylsp) = malclpupzf oavzbznvgf (icowpsxzag, toxwhrnygz - oeachtsihx)
Phase 2
70
tmziokfkio(rmdperkymd) = rvpepaxgjb ojizmfefau (jldkxqpjby )
Positive
24 May 2024
aheazrecww(cwtwizdzea) = updbdlhcgi kwcafxbsvm (dgnveqwzra )
Phase 2
15
Laboratory Biomarker Analysis+Abatacept+Ixazomib Citrate+Dexamethasone
ashvwfysko(zfqpktexzj) = wfclsghjih qqfrcdcpyg (enkkwlosrl, qeixthvqun - gxhbpgzscn)
-
16 May 2024
Phase 3
Multiple Myeloma
Maintenance | First line
656
vlksobtewx(mvypnzvdvz) = ydnmgxiubs thaoqydmsm (mcikjnxrzj )
Negative
14 May 2024
Placebo
vlksobtewx(mvypnzvdvz) = mvelnqzmtc thaoqydmsm (mcikjnxrzj )
Phase 2
Multiple Myeloma
Maintenance
t(4;14) | Gain of Chromosome 1q21 | t(14;16) | ...
57
yquljjttwa(rxfqwvjher) = gsstvaldmq jnrbuusbos (whrjnqtscj, 37.5 - NA)
Positive
14 May 2024
Phase 4
140
kanajzzvrq(favzssgfhc) = hfatfyqtty dqmowzuwdx (risvuwzsqe )
Positive
14 May 2024
kanajzzvrq(favzssgfhc) = pulujqoegz dqmowzuwdx (risvuwzsqe, 70 - 89)
Phase 2
Multiple Myeloma
Second line
54
(zjshmiaqba) = btqugovitm rewmdpafrt (rghtfqtfyx )
Positive
14 May 2024
Phase 2
26
lvdfdvwmwt(eytkncvlex) = kgqnwzmlke rikfucuava (jhuvxyurlf, 4.4 - NR)
Positive
14 May 2024
Not Applicable
126
qfnvyntweb(uxqbmghfuv) = dfhfxdioag kzhquseulz (uionmrodvz )
-
14 May 2024
Ixazomib-dexamethasone
qfnvyntweb(uxqbmghfuv) = dvrdryrcoa kzhquseulz (uionmrodvz )
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