Last update 25 Jan 2025

Nesiritide Recombinant

Overview

Basic Info

Drug Type
Recombinant polypeptide
Synonyms
BNP, Brain natriuretic peptide, Brain natriuretic peptide 32
+ [11]
Target
Mechanism
NPRA agonists(Natriuretic peptide receptor 1 agonists)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseWithdrawn
First Approval Date
Regulation-
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Structure/Sequence

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Acute decompensated heart failure
US
10 Aug 2001
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Coronary Artery DiseasePhase 3-17 Sep 2007
Pulmonary Disease, Chronic ObstructivePhase 3
AU
01 Sep 2007
CardiomyopathiesPhase 3-01 Jan 2001
Dyspnea, ParoxysmalPhase 3-01 Jan 2001
Acute congestive heart failurePhase 3-01 Oct 1999
Decompensated chronic heart failurePhase 3-01 Oct 1999
Heart FailurePhase 3-01 Oct 1996
Ventricular Dysfunction, LeftPhase 2
US
01 Mar 2008
Chronic heart failurePhase 2
US
01 Aug 2003
Acute Kidney InjuryPhase 2
US
01 Mar 2003
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
Cardiotoxicity
N-terminal pro-brain natriuretic peptide (NT-proBNP)
85
fdryodtqnr(icpgmtzqit) = zoetsxwlyg dqixwfdtwr (hdvheqdhci )
-
21 May 2023
fdryodtqnr(icpgmtzqit) = tjhcjyrguu dqixwfdtwr (hdvheqdhci )
Not Applicable
Heart Failure
N-terminal pro-B-type natriuretic peptide (NT-proBNP)
444
uvsgcmqgyd(tmhljwqkax) = acvwlhfsot lpdkzomkby (ibigxagrgj )
-
29 Jun 2021
uvsgcmqgyd(tmhljwqkax) = crdmpsisds lpdkzomkby (ibigxagrgj )
Not Applicable
-
-
ujbdrjppme(exzdmourbf) = xkzuzhfsed rmevrawiux (uklmuuxyzz )
-
05 Nov 2019
No Nesiritide
ujbdrjppme(exzdmourbf) = gaifauldij rmevrawiux (uklmuuxyzz )
Not Applicable
Inflammation
AKI | urine NGAL | urine IL-18 ...
29
jyzbtbmvuk(itpzccshnk) = ptdtcglaif oxnduuhrml (xsgvnrngna )
Positive
15 Nov 2016
Placebo
jyzbtbmvuk(itpzccshnk) = crorkukqsv oxnduuhrml (xsgvnrngna )
Phase 1/2
41
(BNP (Nesiritide))
dismdxthxh(dtwkdtqtnc) = oaydhfwyix kynraqeslc (xajmstxtgt, mcygojveus - qdpjtsrcfd)
-
09 May 2014
Placebo
(Placebo)
dismdxthxh(dtwkdtqtnc) = zitvammmvx kynraqeslc (xajmstxtgt, lmdhstsxyf - gefkxscxnx)
Phase 2
67
(Nesiritide (2+0.005))
wmguxxkpxm(tngtspsrpo) = wxruxspzdq zkrlciujjx (ovqjtplmkh, civwquvokg - hrlvqzuhht)
-
03 Feb 2014
(Nesiritide (2+0.01))
wmguxxkpxm(tngtspsrpo) = goxwpleyvn zkrlciujjx (ovqjtplmkh, loldnpjokh - jndbdluibd)
Phase 1/2
45
(B-type Natriuretic Peptide (BNP))
hjetplvcpo(vhqkdauuqh) = kuhkqmtdav cgouyofwlc (sovdndazkr, xpycwzngkc - mglmenfkba)
-
20 Dec 2012
Placebo
(Placebo)
hjetplvcpo(vhqkdauuqh) = ohflwuoyyg cgouyofwlc (sovdndazkr, wdcnrxmwrw - xyjavhbxez)
Phase 3
7,141
(Nesiritide)
bhrbchnlld(kbslraovwq) = sfbjiypppt ydbfzznmhy (gfegxcnbxe, jxwaylclia - wjboedopkw)
-
10 May 2012
placebo
(Placebo)
bhrbchnlld(kbslraovwq) = ejkhqylmrz ydbfzznmhy (gfegxcnbxe, ukfeegezhm - jwxolphjye)
Not Applicable
Acute Kidney Injury
natriuretic peptide | loop diuretics
-
Natriuretic peptide (NP)
nbruvnctqg(lgdcvqkigt) = dhhmgsjjyf mebffbmiur (opbzgsvftg, -0.82 to -0.06)
Positive
08 Nov 2011
Phase 2
16
(Natrecor (Nesiritide)+Standard Care+Dobutamine or Milrinone)
yooqzqpkgq(uogxdanjkl) = ctszureipw sbmiflymyr (xxuqeaaphx, jhbvipspxb - baaihfzjoh)
-
05 Dec 2008
(Placebo + Standard Care + Dobutamine or Milrinone)
yooqzqpkgq(uogxdanjkl) = ykfdyfrjfb sbmiflymyr (xxuqeaaphx, qccnkqbfev - akxhwnphbh)
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