Delving into the Latest Updates on Nesiritide Recombinant with Synapse

Overview

Basic Info

Drug Type

Recombinant polypeptide

Synonyms

BNP, Brain natriuretic peptide, Brain natriuretic peptide 32

+ [11]

Target

NPRA

Action

agonists

Mechanism

NPRA agonists(Natriuretic peptide receptor 1 agonists)

Therapeutic Areas

Cardiovascular DiseasesRespiratory DiseasesUrogenital Diseases+ [1]

Active Indication-

Inactive Indication

Acute congestive heart failureAcute decompensated heart failureAcute Kidney Injury+ [16]

Originator Organization

Johnson & Johnson

Active Organization-

Inactive Organization

Scios, Inc.

Chengdu Shengnuo Biotechnology Co., Ltd.Janssen-Cilag Pty Ltd.

+ [3]

License Organization

Scios, Inc.

Johnson & Johnson

Drug Highest PhaseWithdrawn

First Approval Date

United States (10 Aug 2001),

Acute decompensated heart failure

Regulation-

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Structure/Sequence

Sequence Code 37334

Source: *****

The congestive heart failure is a common disease among patients who receive cardiac surgery and may lead to prolonged ventilation support. Nesiritide was a potential therapy for congestive heart failure. This study aimed to compare the Nesiritide induced hemodynamical status changes among congestive heart failure patients with invasive ventilation support.

Start Date14 May 2020

Sponsor / Collaborator

Zhongshan Hospital Fudan University

100 Clinical Results associated with Nesiritide Recombinant

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100 Translational Medicine associated with Nesiritide Recombinant

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100 Patents (Medical) associated with Nesiritide Recombinant

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1,690

Literatures (Medical) associated with Nesiritide Recombinant

01 Jul 2025·Journal of Advanced Research

A general strategy for the efficient utilization of Microbiocide by using polyacrylic acid sodium as a flexible framework material

Article

Author: Li, Yingbin ; Liu, Yixiang ; Yan, Weiyao ; Cao, Yongsong ; Tang, Gang ; Liu, Yulu ; Huang, Yuqi ; Zhang, Xiaohong ; Xiao, Jianhua ; Yan, Guangyao ; Zhang, Zhiping ; Hu, Gaohua

INTRODUCTION:

Copper sulfide nanoparticles are ideal carrier materials for the preparation of controlled release nano-systems that can effectively improve the utilization efficiency and environmental safety of microbicides because of their excellent antimicrobial activity, low environmental toxicity, and controllable structure.

OBJECTIVES:

This study aims to elucidate the general rules of loading and release of drugs in pH-responsive nano-delivery systems based on CuS NPs and develop a general strategy for efficient utilization of microbicide and sustainable plant disease management.

METHODS:

Three microbicide-loaded copper sulfide nanoparticles (Microbicide@PAS-CuS NPs) were fabricated via a one-pot route by using polyacrylic acid sodium (PAS) as a flexible framework carrier material and berberine sulfate (BBR), bronopol (BNP), and kasugamycin (KSM) as the loaded microbicides. The physicochemical properties, bioactivity, effective duration, genotoxicity, and plant safety of the obtained Microbicide@PAS-CuS NPs were characterized and evaluated systematically.

RESULTS:

The results indicated that the encapsulation efficiency and microbicide loading capacity of Microbicide@PAS-CuS NPs increased with decreasing LogP values of the microbicides. The obtained Microbicide@PAS-CuS NPs were regular spherical nanoparticles with a uniform particle size, good dispersion stability, and high microbicide loading rate (ranging from 21.36 to 37.50 %) and could respond to the acidic microenvironments associated with pathogen infection to control release the microbicide. Because KSM and BNP were loaded into the channels of nanocapsules formed by incorporating Cu²⁺ and S^2- into PAS nanomicells, their photostabilities were increased by 15.11 and 2.84 times, respectively. Compared with the microbicide alone, the Microbicide@PAS-CuS NPs not only had better antimicrobial activity with a longer effective duration but also improved the safety of both the microbicide and Cu²⁺ to plants.

CONCLUSION:

This study provides a universal strategy to increase the utilization efficiency and environmental safety of microbicides. Microbicide@PAS-CuS NPs have promising applications as novel stimuli-responsive controlled release nano-delivery systems.

01 Jun 2025·CHEMOSPHERE

Green synthesized Zn-based mono and bi-metallic nanoparticles for improved micronutrient delivery: A futuristic study in hydroponic crop culture system

Article

Author: Gogoi, Nayanmoni ; Purkayastha, Karishma Das ; Bhattacharya, Satya Sundar

Hydroponic farming is gaining importance due to the rapid expansion of cities worldwide. However, the significance of nano-enabled nutrient delivery in hydroponic crop culture is still poorly understood. Therefore, ZnO monometallic and Zn-Cu bimetallic nanoparticles (MNP and BNP) were innovatively synthesized through green routes using alcoholic leaf extract (ALE) 1-10 % (w/v) of Chrysalidocarpus lutescens due to its enriched phytochemical profile, prolific radical scavenging efficiency, and reasonably high IC50 values. The structural uniformity and batch-wise yield of MNP and BNP were optimized following response surface methodology. The uniqueness of C. lutescens-derived phytochemicals facilitated the production of anisotropic and crystalline MNP and BNP. It was revealed that structural uniformity and yields were most significant at pH 9 with 3 % ALE for both MNP (Yield/batch -20.54 ± 0.15 g) and BNP (Yield/batch - 18.37 ± 0.30 g). Both nanoparticles were hexagonal 30-85 nm nanocrystals, stable at alkaline pH (∼9) with uniform pore volume, surface area, and surface charge. The hydroponic compatibility of the MNP and BNP were compared with non-nanoscale Zn and Cu by cultivating Cicer arietinum with different doses of MNP, BNP, and other treatments. Among all doses, 250 and 500 mg L^-1 doses of MNP and BNP significantly augmented C. arietinum germination by ∼40-45 % and plumule growth by ∼18-22 % and enhanced chlorophyll stability while reducing oxidative stress in the seedlings. The MNP and BNP were ecologically safe for microorganisms (Rhizobium sp. and Salmonella typhi) and were viable within 250 mg L^-1 to 2000 mg L^-1 of MNP and BNP doses. Overall, the study reveals that the green synthetic routes using C. lutescens phytoextract led to significant yield of productive, biocompatible, and organically rich Zn and Cu-based MNP and BNP that can be easily pursued and sustainably applied in hydroponics or other agriculture platforms.

01 Jun 2025·Materials Today Bio

Bioactive deproteinized bovine bone mineral based on self-assembled albumin nanoparticles promoted bone regeneration via activation of Wnt/β-catenin pathway

Article

Author: Chen, Wei ; Zhu, Ya-Wen ; Wei, Yu-Wen ; Shen, Zhe ; Qiu, Jing ; Ma, Jing-Yi

One of the major problems faced with pre-implant bone reconstruction therapy is that large bone defects do not heal over time. Artificial bone graft materials, such as deproteinized bovine bone mineral, are commonly used in clinics. However, the lack of osteoinductive capacity and risk of post-implantation infections remain key limitations. Bioactive materials with strong bone formation and a high degree of biocompatibility are still needed. In this study, we synthesised bovine serum albumin nanoparticles (BNP) loaded with Tideglusib (TD), TD and BNP were bound together by self-assembly, and mixed with deproteinized bovine bone mineral (DBBM) to form a bone substitute material (TD-BNP@DBBM) that had low cytotoxicity, promoted cell proliferation and migration, induced cell differentiation, and regulated osteogenesis. In vitro, experiments suggested that TD-BNP@DBBM could promote osteoblast differentiation of MC3T3-E1 cells. In vivo, experiments demonstrated that TD-BNP@DBBM significantly accelerated bone reconstruction and enhanced bone healing in a rat cranial defect model. Furthermore, this result suggested a link between the Wnt/β-catenin pathway and the osteogenic effect, providing a basis for subsequent investigations into the mechanism of bone regeneration induced by osteogenic biomaterials. TD-BNP@DBBM might be a promising new approach for treating bone defects.

2

News (Medical) associated with Nesiritide Recombinant

19 Oct 2023

·www.sciencedaily.com

BNP peptide a culprit in eczema

Researchers have pinpointed a particular peptide's role in activating atopic dermatitis, or eczema. The work could lead to more effective treatments for the condition. Researchers from North Carolina State University have pinpointed a particular peptide's role in activating atopic dermatitis, or eczema. The work could lead to more effective treatments for the condition. Atopic dermatitis (AD) is a skin condition characterized by itching, irritated and thickened skin at the site of the irritation. The brain natriuretic peptide (BNP) is a peptide, or short chain of amino acids, that is elevated in patients with AD. "BNP is expressed in sensory neurons, the neurons responsible for conveying sensation to the brain via the spinal cord," says Santosh Mishra, associate professor of molecular biomedical sciences at NC State and corresponding author of the work. "We know from previous work that BNP helps translate the sensation of itch from the skin to the brain. In this work we wanted to see if BNP was involved in activating AD." In a chemically induced mouse model of AD, the researchers saw that mice without BNP did not exhibit the thickened or irritated skin commonly associated with AD, and their itching was reduced compared with control mice who did have BNP. "The results show that BNP likely plays a role in itch activation," Mishra says. "We next looked at BNP's relationship to periostin, to see if we could determine how that activation takes place." Periostin is a protein that can interact with sensory neurons in skin to activate itch response. It is produced in skin cells called keratinocytes and fibroblasts. Keratinocytes in turn, have receptors for BNP, which are called NPR1 receptors. When the BNP receptors are activated, periostin is produced and itch can be turned on. "But the interesting thing here is that the sensory neurons are the activator," Mishra says. The neuron releases BNP, which activates keratinocytes with the NPR1 receptor, which then release the periostin. "This work shows that peripheral neurons, not just central neurons, are playing a role in AD -- it begins in the sensory neurons, and cascades from there," Mishra adds. "It also points to some potential therapeutic strategies, such as blocking BNP's ability to bind to NPR1 receptors in the skin." The research appears as a letter to the editor in the Oct. 11 issue of the Journal of Investigative Dermatology. The work was supported by the National Institutes of Health under grant number 1R56AR077692-01. NC State undergraduate student Junho Yu, former NC State undergraduate student Nidha Williams, and NC State postdoctoral research scholar Joshua Wheeler, also contributed to the work.

26 Apr 2023

·www.prnewswire.com

The Role of Natriuretic Peptides in the Diagnosis and Management of Heart Failure Discussed in New Joint Scientific Statement by the Heart Failure Society of America, Heart Failure Association of the European Society of Cardiology, and Japanese Heart Failure Society

ROCKVILLE, Md., April 26, 2023 /PRNewswire/ -- The Heart Failure Society of America (HFSA), the Heart Failure Association of the European Society of Cardiology (HFA-ESC) and the Japanese Heart Failure Society (JHFS) announced today a joint scientific statement on Natriuretic Peptides: Role in the Diagnosis and Management of Heart Failure. Natriuretic peptides, brain (B-type) natriuretic peptide (BNP) and N-terminal prohormone of brain natriuretic peptide (NT-proBNP), are internationally used as a biomarker for diagnosis and management in adults with heart failure (HF). In addition, natriuretic peptide biomarker data can be important in risk stratification of heart failure prognosis. In addition to biomarker data, implementation of an oral angiotensin receptor neprilysin inhibitor (ARNI) has increased healthcare professionals' awareness of natriuretic peptides as an important therapeutic agent. Natriuretic Peptides: Role in the Diagnosis and Management of Heart Failure scientific statement aims to provide a framework and expert recommendations to healthcare professionals on the diagnosis and management of HF and focuses on the following areas: History and basic research: discovery, production, and cardiovascular protection Diagnostic and prognostic biomarkers: acute HF, chronic HF, inclusion/endpoint in clinical trials, and natriuretic peptides-guided therapy Therapeutic use: nesiritide (BNP), carperitide (ANP), and sacubitril (neprilysin inhibitor [combined with an angiotensin receptor blocker]), and Gaps in knowledge and future directions Standardized screening for HF remains challenging because of the heterogeneity of risk factors across different patient populations. Natriuretic peptides are recommended for initial diagnosis of HF as noted in the 2022 ACC/AHA/HFSA Guideline for the Management of HF, 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic HF, and JCS2017/JHF2017 Guideline on diagnosis and treatment of acute and chronic HF. "There are several differences in the statements among HF Societies regarding the use of natriuretic peptides as biomarkers for risk stratification and prevention. The scientific statement provides up-to-date perspectives and guidance that healthcare professionals can use to navigate and provide the best care for their patients with HF," Nancy Albert, PhD, CCNS, CHFN; co-chair and co-author representing HFSA in the Trilateral International Consensus Conference (TICC) said. The joint scientific statement on natriuretic peptides was developed by the TICC, a collaboration of HFSA, JHFS and HFSA-ESC. The TICC 2021 was hosted by the JHFS and was chaired by Hiroyuki Tsutsui, President of the JHFS, with Nancy M. Albert (HFSA) and Andrew Coats (HFA-ESC) serving as co-chairs. The Natriuretic Peptides: Role in the Diagnosis and Management of Heart Failure scientific statement will jointly publish on Monday 17 April at 9:00 AM EDT in the Journal of Cardiac Failure, the official journal of the HFSA and the JHFS, and the European Journal of Heart Failure, the official journal of the HFA-ESC. DOI: 10.1016/j.cardfail.2023.02.009 To receive a copy of the manuscript in advance of the embargo, contact [email protected]. About the Heart Failure Society of America The Heart Failure Society of America, Inc. (HFSA) represents the first organized effort by heart failure experts from the Americas to provide a forum for all those interested in heart function, heart failure, and congestive heart failure (CHF) research and patient care. The mission of HFSA is to provide a platform to improve and expand heart failure care through collaboration, education, innovation, research, and advocacy. HFSA members include physicians, scientists, nurses, nurse practitioners, pharmacists, trainees, other healthcare workers and patients. For more information, visit hfsa.org. About the Heart Failure Association of the European Society of Cardiology As the world's largest heart failure association, the Heart Failure Association of the ESC prioritizes patient management and awareness of heart failure as a global health problem. HFA-ESC's mission is to improve quality of life and longevity through better prevention, diagnosis and treatment of heart failure, including the establishment of networks for its management, education and research. Learn more online. About the Japanese Heart Failure Society In response to the increased interest in heart failure, based on the basic studies on its mechanisms and clinical trials, the Japanese Heart Failure Society (JHFS) was established in 1996. The first General and Scientific Meeting of the JHFS was held in October 1997 at the Kyoto International Conference Center. The number of members increased from 900 to approximately 4000 in 2020. The vision of JHFS is to enrich the happy life of the patients and their families through investigating the basic pathophysiology of heart failure, and developing the effective and efficient diagnosis, prevention and treatment strategies. About the Journal of Cardiac Failure The Journal of Cardiac Failure (JCF) publishes the highest quality science in the field of heart failure with a focus on diversity, equity, and inclusion, mentorship, multidisciplinary partnerships, and patient-centeredness. Published papers span original investigator-initiated work to state-of-the-art reviews, guidelines and scientific statements, expert perspectives, early career and trainee spotlight pieces, patient and patient-partner narratives. JCF also emphasizes the power of language and prioritizes innovative approaches to dissemination of published work to reach and impact the broader heart failure community. For more information, visit onlinejcf.com. About the European Journal of Heart Failure The European Journal of Heart Failure (EJHF) is dedicated to the advancement of knowledge in the field of heart failure management. The journal publishes reviews and editorials to improve the understanding, prevention, investigation and treatment of heart failure. Molecular and cellular biology, pathology, physiology, electrophysiology, pharmacology, as well as clinical, social and population sciences all form part of the discipline. Visit EJHF online. Media Contact: Laura Poko: Director of Marketing and Communications, Heart Failure Society of America, 301-798-4493, ext. 226 [email protected] Olivia Seward: Associate Director Communication, European Society of Cardiology, +33 (0)4 89 87 20 10, [email protected] SOURCE Heart Failure Society of America

100 Deals associated with Nesiritide Recombinant

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External Link

KEGG	Wiki	ATC	Drug Bank
-	Nesiritide Recombinant	C01DX19	DB04899

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Acute decompensated heart failure	United States	Scios LLC	10 Aug 2001

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Coronary Artery Disease	Phase 3	-	Scios, Inc.	17 Sep 2007
Pulmonary Disease, Chronic Obstructive	Phase 3	Australia	Janssen-Cilag Pty Ltd.	01 Sep 2007
Renal Insufficiency	Phase 3	United States	Scios, Inc.	01 Mar 2003
Cardiomyopathies	Phase 3	-	Scios, Inc.	01 Jan 2001
Dyspnea, Paroxysmal	Phase 3	-	Scios, Inc.	01 Jan 2001
Acute congestive heart failure	Phase 3	-	Scios, Inc.	01 Oct 1999
Decompensated chronic heart failure	Phase 3	-	Scios, Inc.	01 Oct 1999
Heart failure NYHA class IV	Phase 3	-	Scios, Inc.	01 Aug 1998
Chronic congestive heart failure	Phase 3	-	Scios, Inc.	01 Oct 1996
Heart Failure	Phase 3	-	Scios, Inc.	01 Oct 1996

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT00543309 (CTgov)	Phase 2	Heart Defects, Congenital	106	nesiritide (I- Nesiritide)	cxcuomfdoa(infwetrlgt) = losowizfqw ahwrpiamau (wusjpwmpyf, jdhzonnnyh - famnplrgtm) View more	-	25 Jun 2018
				milrinone (II- Milrinone)	cxcuomfdoa(infwetrlgt) = hntjwjcudc ahwrpiamau (wusjpwmpyf, xexxkamumh - nwzfgbcfws) View more
NCT00475852 (ASCEND-HF, Pubmed \| Circ Heart Fail)	Phase 3	Acute decompensated heart failure	7,141	Nesiritide (High enrolling sites)	gwfnxcfguy(sitoapqfjq): hazard ratio = 0.99 (95% CI, 0.98 - 1.01) View more	-	01 Sep 2016
				Nesiritide (Low enrolling sites)
NCT00475852 (ASCEND-HF, Pubmed \| BMJ Open)	Phase 3	Heart Failure	1,068	Nesiritide (Self-presentation)	yqmkvqppmk(zetjdlfybk) = avwuufiilp pzcsbeukha (gmqdpmjfam ) View more	-	17 Mar 2016
				Nesiritide (Ambulance)	yqmkvqppmk(zetjdlfybk) = wplutasreu pzcsbeukha (gmqdpmjfam ) View more
NCT00475852 (ASCEND-HF, Pubmed \| J Am Heart Assoc)	Phase 3	Heart Failure \| Atrial Fibrillation	7,007	nesiritide (Patients with AF)	vgvakghapz(llrmsvjhjs) = rcikkpbgwo gqoqcijotb (lqlvmkkkbb )	-	24 Aug 2015
				nesiritide (Patients without AF)	vgvakghapz(llrmsvjhjs) = lspzwujgbd gqoqcijotb (lqlvmkkkbb )
NCT00475852 (ASCEND-HF, Pubmed \| Circulation)	Phase 3	Acute decompensated heart failure	7,141	Nesiritide	juynvtgmxm(ooyczqmaso) = xrqjstrxzm wwfngrhguk (pkmlftaobb ) View more	-	16 Sep 2014
				Placebo	juynvtgmxm(ooyczqmaso) = ghcbhefzew wwfngrhguk (pkmlftaobb ) View more
NCT00573144 (Believe II, CTgov)	Phase 2	Anterior Wall Myocardial Infarction \| Acute myocardial infarction	59	Placebo (Placebo)	tnfpwntmpj(jdbijcjeaw) = pqthzuzjxx ynqdkecdeu (aaqblzkjdu, 58) View more	-	09 Sep 2014
				Nesiritide (Nesiritide)	tnfpwntmpj(jdbijcjeaw) = lzvojgbpdr ynqdkecdeu (aaqblzkjdu, 31) View more
NCT01132846 (ROSE/RED ROSE \| ROSE, CTgov)	Phase 2	Dyspnea \| Heart Failure	360	Dopamine (Low Dose Dopamine)	kpodjgdhjr(knfjazwlox) = ulkantrhih osftwftows (hpwnfokypa, .32) View more	-	21 Aug 2014
				Placebo (Placebo)	kpodjgdhjr(knfjazwlox) = nabtvlvpbi osftwftows (hpwnfokypa, .27) View more
NCT01836809 (CTgov)	Phase 4	Cardio-Renal Syndrome	2	nesiritide (Total Artificial Heart)	tpyusxccle(vctfjymltz) = jrszlzvzna zvkdjmloey (bgoydmlcgg, nkticiidgk - jijvfwwclx) View more	-	18 Aug 2014
				placebo (Total Artificial Heart: Placebo)	tpyusxccle(vctfjymltz) = iipsfwrpji zvkdjmloey (bgoydmlcgg, javkbpppud - akqyukbroj) View more
NCT00405548 (CTgov)	Phase 1/2	Ventricular Dysfunction, Left	41	BNP (nesiritide) (BNP (Nesiritide))	joemhscfdh(tbbopbzdat) = jicikpepzy xadigtoxtq (petvbljaxh, 450.8) View more	-	09 May 2014
				Placebo (Placebo)	joemhscfdh(tbbopbzdat) = jhszebotwt xadigtoxtq (petvbljaxh, 90.1) View more

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Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

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