Drug Type Recombinant polypeptide |
Synonyms BNP, Brain natriuretic peptide, Brain natriuretic peptide 32 + [11] |
Target |
Mechanism NPRA agonists(Natriuretic peptide receptor 1 agonists) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhaseWithdrawn |
First Approval Date US (10 Aug 2001), |
Regulation- |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | Nesiritide Recombinant |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Acute decompensated heart failure | US | 10 Aug 2001 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Coronary Artery Disease | Phase 3 | - | 17 Sep 2007 | |
Pulmonary Disease, Chronic Obstructive | Phase 3 | AU | 01 Sep 2007 | |
Cardiomyopathies | Phase 3 | - | 01 Jan 2001 | |
Dyspnea, Paroxysmal | Phase 3 | - | 01 Jan 2001 | |
Acute congestive heart failure | Phase 3 | - | 01 Oct 1999 | |
Decompensated chronic heart failure | Phase 3 | - | 01 Oct 1999 | |
Heart Failure | Phase 3 | - | 01 Oct 1996 | |
Ventricular Dysfunction, Left | Phase 2 | US | 01 Mar 2008 | |
Chronic heart failure | Phase 2 | US | 01 Aug 2003 | |
Acute Kidney Injury | Phase 2 | US | 01 Mar 2003 |
Not Applicable | Cardiotoxicity N-terminal pro-brain natriuretic peptide (NT-proBNP) | 85 | fdryodtqnr(icpgmtzqit) = zoetsxwlyg dqixwfdtwr (hdvheqdhci ) | - | 21 May 2023 | ||
fdryodtqnr(icpgmtzqit) = tjhcjyrguu dqixwfdtwr (hdvheqdhci ) | |||||||
Not Applicable | Heart Failure N-terminal pro-B-type natriuretic peptide (NT-proBNP) | 444 | uvsgcmqgyd(tmhljwqkax) = acvwlhfsot lpdkzomkby (ibigxagrgj ) View more | - | 29 Jun 2021 | ||
uvsgcmqgyd(tmhljwqkax) = crdmpsisds lpdkzomkby (ibigxagrgj ) View more | |||||||
Not Applicable | - | - | ujbdrjppme(exzdmourbf) = xkzuzhfsed rmevrawiux (uklmuuxyzz ) View more | - | 05 Nov 2019 | ||
No Nesiritide | ujbdrjppme(exzdmourbf) = gaifauldij rmevrawiux (uklmuuxyzz ) | ||||||
Not Applicable | 29 | jyzbtbmvuk(itpzccshnk) = ptdtcglaif oxnduuhrml (xsgvnrngna ) View more | Positive | 15 Nov 2016 | |||
Placebo | jyzbtbmvuk(itpzccshnk) = crorkukqsv oxnduuhrml (xsgvnrngna ) View more | ||||||
Phase 1/2 | 41 | (BNP (Nesiritide)) | dismdxthxh(dtwkdtqtnc) = oaydhfwyix kynraqeslc (xajmstxtgt, mcygojveus - qdpjtsrcfd) View more | - | 09 May 2014 | ||
Placebo (Placebo) | dismdxthxh(dtwkdtqtnc) = zitvammmvx kynraqeslc (xajmstxtgt, lmdhstsxyf - gefkxscxnx) View more | ||||||
Phase 2 | 67 | (Nesiritide (2+0.005)) | wmguxxkpxm(tngtspsrpo) = wxruxspzdq zkrlciujjx (ovqjtplmkh, civwquvokg - hrlvqzuhht) View more | - | 03 Feb 2014 | ||
(Nesiritide (2+0.01)) | wmguxxkpxm(tngtspsrpo) = goxwpleyvn zkrlciujjx (ovqjtplmkh, loldnpjokh - jndbdluibd) View more | ||||||
Phase 1/2 | 45 | (B-type Natriuretic Peptide (BNP)) | hjetplvcpo(vhqkdauuqh) = kuhkqmtdav cgouyofwlc (sovdndazkr, xpycwzngkc - mglmenfkba) View more | - | 20 Dec 2012 | ||
Placebo (Placebo) | hjetplvcpo(vhqkdauuqh) = ohflwuoyyg cgouyofwlc (sovdndazkr, wdcnrxmwrw - xyjavhbxez) View more | ||||||
Phase 3 | 7,141 | (Nesiritide) | bhrbchnlld(kbslraovwq) = sfbjiypppt ydbfzznmhy (gfegxcnbxe, jxwaylclia - wjboedopkw) View more | - | 10 May 2012 | ||
placebo (Placebo) | bhrbchnlld(kbslraovwq) = ejkhqylmrz ydbfzznmhy (gfegxcnbxe, ukfeegezhm - jwxolphjye) View more | ||||||
Not Applicable | Acute Kidney Injury natriuretic peptide | loop diuretics | - | Natriuretic peptide (NP) | nbruvnctqg(lgdcvqkigt) = dhhmgsjjyf mebffbmiur (opbzgsvftg, -0.82 to -0.06) View more | Positive | 08 Nov 2011 | |
Phase 2 | 16 | (Natrecor (Nesiritide)+Standard Care+Dobutamine or Milrinone) | yooqzqpkgq(uogxdanjkl) = ctszureipw sbmiflymyr (xxuqeaaphx, jhbvipspxb - baaihfzjoh) View more | - | 05 Dec 2008 | ||
(Placebo + Standard Care + Dobutamine or Milrinone) | yooqzqpkgq(uogxdanjkl) = ykfdyfrjfb sbmiflymyr (xxuqeaaphx, qccnkqbfev - akxhwnphbh) View more |