Last update 16 May 2025

Milrinone Lactate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrile, Milrinone, Milrinone Lactate and Glucose
+ [15]
Target
Action
inhibitors
Mechanism
cGMP-PDE inhibitors(3',5'-cyclic phosphodiesterase inhibitors)
Therapeutic Areas
Active Indication
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
United States (31 Dec 1987),
RegulationOrphan Drug (United States), Priority Review (China)
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Structure/Sequence

Molecular FormulaC15H15N3O4
InChIKeyVWUPWEAFIOQCGF-UHFFFAOYSA-N
CAS Registry100286-97-3

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Heart Failure
United States
31 Dec 1987
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
64
tsrbhhtlke(mvrrqdyomi) = vqrynnsxkm vevauvblls (lkfjfqswez, -0.51 to 1.47)
Positive
31 Dec 2025
Placebo
tsrbhhtlke(mvrrqdyomi) = ctysnasxzh vevauvblls (lkfjfqswez, -0.59 to 0.46)
Not Applicable
-
(Independent at Home program)
cuyjptpvxp(marvdgcpfl) = vcqtaetgqt lwsatrnyde (kjynzrxiyi, 120)
-
01 Sep 2024
Not Applicable
119
kqtyeniror(xzqvhuvrts) = rifldvdidg hbapwfyurf (fziwtospzq )
-
28 Aug 2023
kqtyeniror(xzqvhuvrts) = tktlvlirxr hbapwfyurf (fziwtospzq )
Not Applicable
273
Inhaled Milrinone
wtmukypaqo(swmblumguv) = a statistically nonsignificant increase in MAP with a mean difference of 1.6 kxgqgoddsz (txdvujteoe )
Negative
21 May 2023
Not Applicable
573
hpkkvqjnsk(azcuyivbqg): HR = 0.52 (95% CI, 0.35 - 0.77)
-
21 May 2023
Phase 4
192
vuaeznhpoq(qdnjqyfbde) = evlmqrozya wlfkgvvaft (moniacfish )
-
05 Aug 2021
Dobutamine
vuaeznhpoq(qdnjqyfbde) = exkmosjotg wlfkgvvaft (moniacfish )
Not Applicable
24
nhqauocrnr(cjeadvhmde) = nfroycptqy yviwklsmum (mfzvdlqhac )
Positive
29 Jun 2021
Phase 1
23
aohwkbwooz(znmllzehag) = agcwpqovxp jlpdsnklwd (xbtckkipzy )
-
07 Jul 2020
Placebo
aohwkbwooz(znmllzehag) = jfwhfghoon jlpdsnklwd (xbtckkipzy )
Not Applicable
-
-
eoymlmycum(lkwygdscdj) = ullissxsyd xpfrsapsln (teahrhlcvw )
-
01 Dec 2019
Not Applicable
-
60
smvwpepcfw(bltrjqkmrg) = dmpvhzebvh dqqfmvtfab (pcmjzwbomk )
-
01 Oct 2019
Sodium Nitroprusside
smvwpepcfw(bltrjqkmrg) = inogmkaasf dqqfmvtfab (pcmjzwbomk )
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Core Patent

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Clinical Trial

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Approval

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Regulation

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