Colonoscopy Preparation: Comparing Sennoside A+B and PM/Ca
Colonoscopy is a test used to examine the inside of the bowel. Proper bowel preparation is crucial because it helps doctors get a clear view during the procedure.
What is Sennoside A+B? Sennoside A+B is a type of laxative made from the senna plant. It works by stimulating the bowel to move and reducing the absorption of water, making it easier to pass stools. Research has shown that high doses of sennoside A+B can be effective for bowel preparation.
Sennoside A+B vs. PEG:
Some studies have found that sennoside A+B is more effective than PEG, another laxative, but can cause more abdominal pain. Other studies have found no significant difference in effectiveness between the two.
What is Picosulfate/Magnesium Oxide/Citric Acid (PM/Ca)? PM/Ca is a combination of sodium picosulfate, magnesium oxide, and citric acid. Sodium picosulfate stimulates bowel movements, while magnesium oxide and citric acid help increase water in the bowel, making it easier to pass stools.
PM/Ca vs. PEG:
Research has shown that PM/Ca is as effective as PEG for bowel preparation. Patients using PM/Ca generally tolerate the preparation process better than those using PEG.
Conclusion:
While PEG is the preferred option according to guidelines, its high cost can make it less accessible in some places. In this study, we aim to compare the effectiveness and patient tolerance of Sennoside A+B and PM/Ca since no direct comparison between these two preparations has been made before.

Start Date22 Aug 2024

Sponsor / Collaborator

Hittite University

NCT03593252

/ Unknown statusNot ApplicableIIT

Pre-Operative Mechanical Bowel Preparation And Prophylactic Oral Antibiotics For Pediatric Patients Undergoing Elective Colorectal Surgery: A Feasibility Randomized Controlled Trial

Infections after elective intestinal surgery remain a significant burden for patients and for the health care system. The cost of treating a single surgical site infection is estimated at approximately $27,000. In adult patients, there is good evidence that the combination of oral antibiotics and mechanical bowel preparation is effective at reducing infections after intestinal surgery. In children, the body of evidence is much weaker. In this population, little evidence exists for oral antibiotics reducing infections and no data exists as to the effect of combining antibiotics with mechanical bowel preparation (such as polyethylene glycol (PEG)). The goal of the proposed study is to examine the effects of oral antibiotics with and without the combined use of mechanical bowel preparation on the rate of post-operative infectious complications in children aged 6 months to 18 years. This will be compared to the institution's current standard of care, which is to abstain from any type of mechanical bowel preparations or oral antibiotic administration before intestinal surgery.

Start Date01 Jan 2022

Sponsor / Collaborator

McMaster University

NCT03491540

/ CompletedPhase 3IIT

Mechanical Bowel Preparation and Oral Antibiotics Before Rectal Cancer Surgery: a Multi Center Double-Blinded Randomized Controlled Trial (PREPACOL2 Study)

This study aims to demonstrate that a preoperative combination of mechanical bowel preparation and oral antibiotics, before elective laparoscopic rectal cancer surgery, is associated with a reduction of postoperative surgical site infection rate, as compared to mechanical bowel preparation alone Our hypothesis is that a preoperative colonic preparation including a combination of mechanical bowel preparation and oral antibiotics before elective laparoscopic rectal cancer surgery is associated with a reduced rate of 30-day postoperative surgical site infection, as compared to mechanical bowel preparation alone

Start Date03 Sep 2018

Sponsor / Collaborator

Assistance Publique des Hôpitaux de Paris SA

100 Clinical Results associated with Sennosides

100 Translational Medicine associated with Sennosides

100 Patents (Medical) associated with Sennosides

919

Literatures (Medical) associated with Sennosides

01 Mar 2025·Journal of Food Composition and Analysis

Plant tissue-driven differentiation of bioactive compounds and mineral elements in Rheum tanguticum and their correlation

Author: Zhou, Guoying ; Ma, Huiyuan ; Li, Jianan ; Wang, Bo ; Yang, Xue ; Zhao, Shuo

Mineral elements are important to nutrient absorption and secondary metabolite accumulation in plants.Rheum tanguticum Maxim. ex Regel increasingly becomes scarce due to overexploitation.Consequently, it is imperative to address market demand through artificial cultivation and to explore the value of various plant tissues.We selected two sites with distinct altitude differences to collect roots, petioles, and leaves of both wild and cultivated R. tanguticum, determining the contents of sennoside A, gallic acid, emodin, and chrysophanol and analyzing 17 elements, including Ca, Na, Ba, and more, in the samples.Our results indicated that, except for emodin, the content of other bioactive compounds exhibited a decreasing trend from root to leaf.The wild rhubarbs were of higher quality at high altitudes, while the cultivated at lower altitudes had higher levels of anthraquinones.Meanwhile, significant differences were observed in the elemental content across different tissues, with a decreasing trend from aboveground to underground.A strong correlation existed between elements and bioactive compounds, with more pos. correlations observed in the roots.Elements such as B, Cr, Na, and Zn demonstrated a significant pos. correlation with the bioactive compoundsThis study provides scientific foundations for the quality identification and control of R. tanguticum.

10 Jan 2025·ACS Pharmacology & Translational Science

Thiol-Reactive or Redox-Active: Revising a Repurposing Screen Led to a New Invalidation Pipeline and Identified a True Noncovalent Inhibitor Against Papain-like Protease from SARS-CoV-2

Article

Author: Beccari, Andrea R. ; Gribbon, Philip ; Reinshagen, Jeanette ; Monti, Maria ; Cozzolino, Flora ; Corona, Angela ; Iaconis, Daniela ; Manelfi, Candida ; Paulis, Annalaura ; Monaco, Vittoria ; Summa, Vincenzo ; Golič Grdadolnik, Simona ; Storici, Paola ; Zaliani, Andrea ; Plavec, Janez ; Šket, Primož ; Esposito, Francesca ; Windshügel, Björn ; Kuzikov, Maria ; Wolf, Markus ; Morasso, Stefano ; Tramontano, Enzo

The SARS-CoV-2 papain-like protease PLpro has multiple roles in the viral replication cycle, related to both its polypeptide cleavage function and its ability to antagonize the host immune response. Targeting the PLpro function is recognized as a promising mechanism to modulate viral replication, while supporting host immune responses. However, the development of PLpro-specific inhibitors remains challenging. Comprehensive investigations utilizing enzymatic, binding studies, and cellular assays revealed the previously reported inhibitors to act in an unspecific manner. At present, GRL-0617 and its derivatives remain the best-validated compounds with demonstrated antiviral activity in cells and in mouse models. In this study, we refer to the pitfalls of the redox sensitivity of PLpro. Using a screening-based approach to identify inhibitors of PLpro's proteolytic activity, we made extensive efforts to validate active compounds over a range of conditions and readouts, emphasizing the need for comprehensive orthogonal data when profiling putative PLpro inhibitors. The remaining active compound, CPI-169, was shown to be a noncovalent inhibitor capable of competing with GRL-0617 in NMR-based experiments, suggesting that it occupied a similar binding site and inhibited viral replication in Vero-E6 cells, opening new design opportunities for further development as antiviral agents.

01 Jan 2025·Biomedical Chromatography

Determination of Sennoside A in Rat Plasma by Liquid Chromatography/Electrospray Ionization Tandem Mass Spectrometry and Its Application to a Rat Pharmacokinetic Study

Article

Author: Gu, Yifan ; Qi, Wen ; Gu, Chunyan ; Chu, Feifei ; Shen, Jiawei ; Sun, Jingjing

ABSTRACTTo characterize pharmacokinetic profile of sennoside A in rats after intravenous and oral administration, a simple and sensitive liquid chromatography tandem mass spectrometry method was established and validated for quantitative determination of sennoside A in rat plasma. After prepared by protein precipitation with acetonitrile, sennoside A and internal standard were separated on a Waters ACQUITY HSS T3 (2.1 × 100 mm, 1.8 μm) column using acetonitrile and 5‐mM ammonium acetate in water as mobile phase by gradient elution. The method showed excellent linearity over the range of 0.5–1000 ng/mL with acceptable intra‐ and inter‐day precision, accuracy, matrix effect, and recovery. The stability assay indicated that sennoside A was stable in plasma during the sample collection, preparation, and analysis. Next, the method was applied to pharmacokinetic study of sennoside A in rats. After intravenous and intragastric administrated to rats, the concentrations of sennoside A in plasma at different time points were quantitated and the pharmacokinetic parameters were calculated by software of DAS 2.0. Pharmacokinetic parameters suggested that after oral administration, sennoside A was reached to the peak at 2.9–3.6 h with a Cmax value of 13.2–31.7 ng/mL. Sennoside A was eliminated slowly from the plasma with T1/2 value between 15.4 and 18.3 h. The oral absolute bioavailability was among 0.9%–1.3%, which indicated low blood exposure level.

100 Deals associated with Sennosides

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KEGG	Wiki	ATC	Drug Bank
D02171	-	A06AB06	DB11365

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Indication	Country/Location	Organization	Date
Constipation	Japan	Sun Pharma Japan Ltd.	01 Jul 1967

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT02481219 (CTgov)	Not Applicable	Colorectal Cancer	122	SUPREP oral sulfate solution+PEG+Metoclopramide+Bisacodyl+Senna tablets+Erythromycin (Bowel Preparation Regimen -Control)	lipzzhahkj(uwxtwtdsua) = gtmzdgbqzs ojtybfewyo (pwhldxtnef, kvqdqspuux - ilecprexzx) View more	-	11 Jul 2016
				SUPREP oral sulfate solution+PEG+Metoclopramide+Bisacodyl+Senna tablets+Erythromycin (Bowel Preparation Regimen-Test)	lipzzhahkj(uwxtwtdsua) = voxmuytvcc ojtybfewyo (pwhldxtnef, bgefzwxtnb - cayxxchodn) View more

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