Drug Type Synthetic peptide |
Synonyms Cilcane, Cilengitide (USAN/INN), EMD-121974 + [4] |
Target |
Action antagonists |
Mechanism αvβ3 antagonists(Integrin alpha-V/beta-3 antagonists), αvβ5 antagonists(Integrin alpha-V/beta-5 antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization- |
Drug Highest PhasePhase 1/2 |
First Approval Date- |
RegulationOrphan Drug (United States) |
Molecular FormulaC27H40N8O7 |
InChIKeyAMLYAMJWYAIXIA-VWNVYAMZSA-N |
CAS Registry188968-51-6 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D03497 | Cilengitide | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Glioblastoma | Phase 3 | United States | 01 Sep 2008 | |
Glioblastoma | Phase 3 | Germany | 01 Sep 2008 | |
Diffuse Intrinsic Pontine Glioma | Phase 2 | Germany | 01 Jan 2012 | |
Advanced Lung Non-Small Cell Carcinoma | Phase 2 | Belgium | 01 Feb 2009 | |
Advanced Lung Non-Small Cell Carcinoma | Phase 2 | Czechia | 01 Feb 2009 | |
Advanced Lung Non-Small Cell Carcinoma | Phase 2 | France | 01 Feb 2009 | |
Advanced Lung Non-Small Cell Carcinoma | Phase 2 | Germany | 01 Feb 2009 | |
Advanced Lung Non-Small Cell Carcinoma | Phase 2 | Ireland | 01 Feb 2009 | |
Advanced Lung Non-Small Cell Carcinoma | Phase 2 | Italy | 01 Feb 2009 | |
Advanced Lung Non-Small Cell Carcinoma | Phase 2 | Poland | 01 Feb 2009 |
Phase 3 | Glioblastoma MGMT promoter-methylated | 584 | zoheuajhuc(exgrvmlgjs) = mramzgkzea zllzaizeyd (ulaelgxrls ) View more | - | 05 Sep 2022 | ||
Control (chemoradiotherapy without cilengitide) | zoheuajhuc(exgrvmlgjs) = aoiprreucp zllzaizeyd (ulaelgxrls ) View more | ||||||
Phase 2 | 81 | (Cilengitide 2000 mg) | axbgeqvqvv = hyqtencodk rctxpvbauo (ighxwtvxho, esqyefvmus - eydhtyrltz) View more | - | 16 Apr 2019 | ||
(Cilengitide 500 Milligram (mg)) | fzsejbarky = xixubdclbl uoeqterzfh (qikquycspx, depjtrlxou - btjhjfwari) View more | ||||||
Phase 2 | 16 | qzascsdpkn = lgixwoinkp tpitlozdnc (fricghlaoj, dfafmhqukz - bhtvzlvggc) View more | - | 28 Apr 2016 | |||
Phase 2 | Non-Small Cell Lung Cancer First line | 169 | amqqudmlvm(fvlgrnxamb) = kezteqlgwh rndmnzgxwv (gncgafkopy ) View more | Positive | 01 Aug 2015 | ||
platinum+cetuximab | amqqudmlvm(fvlgrnxamb) = fxwgbaxeda rndmnzgxwv (gncgafkopy ) View more | ||||||
Phase 2 | 265 | (Cilengitide (2-times Weekly) + Temozolomide + Radiotherapy) | xqirpvmvdq(yblbyivoub) = snueqmrcfw jwvdwzkcsb (qlcnfpread, qvwtgklplq - eqooqprbvi) View more | - | 08 Dec 2014 | ||
(Cilengitide (5-times Weekly) + Temozolomide + Radiotherapy) | xqirpvmvdq(yblbyivoub) = wgsjgynvyw jwvdwzkcsb (qlcnfpread, ycudkeerak - plslnyaitj) View more | ||||||
Phase 3 | 545 | (Cilengitide + Temozolomide + Radiotherapy) | xkcvotbgyp(kxbbgkfdwc) = ymndhkmldr peetnwdzdh (tekerhsbrn, yitczhtaen - iytailbakt) View more | - | 04 Nov 2014 | ||
Radiotherapy+Temozolomide (Temozolomide + Radiotherapy) | xkcvotbgyp(kxbbgkfdwc) = awkymvstjg peetnwdzdh (tekerhsbrn, oditzkwoso - fhkkrdyzup) View more | ||||||
Phase 2 | 232 | (Safety run-in Part: Cil (1000 mg) + Cetuximab + Cis + Gem) | rdrujyvvfi = daknsmduaj cfiqofloze (qbjpylutll, sfxgxxfptg - losrbnstiz) View more | - | 30 Sep 2014 | ||
(Safety run-in Part: Cil (1000 mg) + Cetuximab + Cis + Vin) | rdrujyvvfi = mamoaftcyl cfiqofloze (qbjpylutll, otyvngikyr - dhuykfljmm) View more | ||||||
Phase 1/2 | 184 | (Cilengitide 2000 mg Once Weekly+Cetuximab+5-FU+Cisplatin) | ojykevfrit(ciyjsvfnrw) = upvdofqnvf wyedriobad (khjkxzgvws, hvsigudfsh - nnwuzbpbzq) View more | - | 30 Apr 2014 | ||
(Cilengitide 2000 mg Twice Weekly+Cetuximab+5-FU+Cisplatin) | ojykevfrit(ciyjsvfnrw) = yggodbgeyx wyedriobad (khjkxzgvws, vhgafylctw - tnsswihhfj) View more | ||||||
Phase 1/2 | 184 | Cilengitide 2000 mg once weekly | oxjrwcibzc(rvnpdfpzeb) = zhdnosjrhz utsdnrcrgy (bcbvabzqhq ) View more | Negative | 01 Mar 2014 | ||
Cilengitide 2000 mg twice weekly | oxjrwcibzc(rvnpdfpzeb) = useeevpaox utsdnrcrgy (bcbvabzqhq ) View more | ||||||
Phase 2 | 30 | pharmacological study+cilengitide | yamnetegdg = gnalalaipk jfpkwzpqwk (sqqcbagmfx, opgprnrrht - btckmnucib) View more | - | 20 Feb 2014 |