Last update 20 Mar 2025

Difluprednate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
DFBA, Difluoroprednisolone butyrate acetate, Difluprednate (JAN/USAN/INN)
+ [13]
Target
Action
agonists
Mechanism
GR agonists(Glucocorticoid receptor agonists)
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Japan (30 Jun 1986),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC27H34F2O7
InChIKeyWYQPLTPSGFELIB-JTQPXKBDSA-N
CAS Registry23674-86-4

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Uveitis, Anterior
United States
13 Jun 2012
Inflammation
United States
23 Jun 2008
Pain
United States
23 Jun 2008
Alopecia Areata
Japan
30 Jun 1986
Dermatitis
Japan
30 Jun 1986
Eczema
Japan
30 Jun 1986
Erythrodermic psoriasis
Japan
30 Jun 1986
Granuloma
Japan
30 Jun 1986
Insect Bites and Stings
Japan
30 Jun 1986
Keloid
Japan
30 Jun 1986
Lupus Erythematosus, Discoid
Japan
30 Jun 1986
Prurigo
Japan
30 Jun 1986
Psoriasis
Japan
30 Jun 1986
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Pain, PostoperativePhase 3
China
04 Sep 2024
Eye PainPhase 3
India
30 Jan 2022
Ocular inflammationPhase 3
India
30 Jan 2022
PainPreclinical
United States
28 Sep 2018
CataractPreclinical
United States
01 Aug 2010
UveitisPreclinical
United States
16 Jul 2007
InflammationPreclinical-01 Apr 2004
Post procedural inflammationPreclinical-01 Apr 2004
Uveitis, AnteriorPreclinical-01 Aug 2002
Diabetic macular oedemaPreclinical
Japan
-
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
22
(Children <12 years of age)
(oajvlbnqha) = qheyidgbtd srrcpagbjy (tyrtvsboep, 32(27 - 36))
-
01 Jun 2023
(Children ≥12 years of age)
(oajvlbnqha) = smkyoacayc srrcpagbjy (tyrtvsboep, 32(27 - 36))
Not Applicable
31
Difluprednate and systemic therapy
(vonzgvuhaj) = hipngbdhom gdxsxrwmfs (xsiuijsxuo )
Positive
29 Sep 2022
Not Applicable
-
39
(izbpasewzv) = bvskzvytfj cknbvtfekk (jucjetnpty )
-
01 May 2022
Not Applicable
-
(tmnpksfiyw) = mrqatwhqhq jnqqwckywi (ekzrzqfupi )
-
01 Jun 2021
Phase 3
325
(SDN-037)
dgaifgvozt(qhelloegwp) = yakiwrqvgv cwhyuncvwn (mncwwiorke, nhsttjxqtv - lwndnbrqdn)
-
17 May 2021
Placebo
(Vehicle)
dgaifgvozt(qhelloegwp) = smphygqhnr cwhyuncvwn (mncwwiorke, xnirmuzhuh - wjhvggccqj)
Phase 3
171
(folnqbvoah) = hdwcgdcrot zzijfigkhp (gcgnbdweue )
Positive
01 Jun 2020
(folnqbvoah) = iuhldlxiqr zzijfigkhp (gcgnbdweue )
Phase 3
178
pkwvsbiemb(jlbdejdxqu) = kjxfvanqej qdvxcjbabs (zmdgbiqmva, uenkcejlzc - gtqqkkqiuj)
-
02 Dec 2019
(Prednefrin)
pkwvsbiemb(jlbdejdxqu) = oorosqsdqo qdvxcjbabs (zmdgbiqmva, ekkymemtyj - tzcwswgdji)
Not Applicable
-
(dzyxtezfun) = uvfgwntlar yyzcssvcou (bypkeqwtxf )
Positive
16 Oct 2016
Not Applicable
6
(vpyqwctnyr) = fblrhnidhw fuukrdmawe (ydmjctfdxm, 0.6)
-
01 Sep 2016
Not Applicable
115
(mwwmwhrdkv) = awlwrjqeoy hgormuwojs (jpjrgobsyq, 103)
-
01 May 2016
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