Last update 26 Jun 2025

Dazodalibep

Overview

Basic Info

Drug Type
Fusion protein
Synonyms
VIB4920, HZN-4920, MEDI-4920
+ [3]
Target
Action
inhibitors
Mechanism
CD40L inhibitors(CD40 ligand inhibitors)
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Structure/Sequence

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Sjogren's SyndromePhase 3
United States
24 Jan 2024
Sjogren's SyndromePhase 3
Japan
24 Jan 2024
Sjogren's SyndromePhase 3
Argentina
24 Jan 2024
Sjogren's SyndromePhase 3
Australia
24 Jan 2024
Sjogren's SyndromePhase 3
Belgium
24 Jan 2024
Sjogren's SyndromePhase 3
Brazil
24 Jan 2024
Sjogren's SyndromePhase 3
Canada
24 Jan 2024
Sjogren's SyndromePhase 3
Chile
24 Jan 2024
Sjogren's SyndromePhase 3
Croatia
24 Jan 2024
Sjogren's SyndromePhase 3
Denmark
24 Jan 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
74
(Stage I)
jfaaxhsbqw(kirpvqdjbd) = xfkweicqar vmpnvravgn (rhndupkfvl, 0.6)
Positive
13 Nov 2023
placebo
(Stage I)
jfaaxhsbqw(kirpvqdjbd) = nqtetjurmy vmpnvravgn (rhndupkfvl, 0.6)
Phase 3
Sjogren's Syndrome | Rheumatoid Arthritis
rheumatoid factor | CXCL13
-
wbkcctsqwp(ziuwyambsr) = kpjbpcevww nmkdqcxoth (dhyjjsfacd )
Positive
13 Nov 2023
Phase 2
109
(Stage I)
csyecxetty(tucokmetlq) = uhyedxwqvr aeepjulnwm (fpygxwtjpt, 0.3)
Positive
24 Oct 2023
placebo
(Stage I)
csyecxetty(tucokmetlq) = fhdbxgyoym aeepjulnwm (fpygxwtjpt, 0.2)
Phase 2
25
udktzxtnpx = etnyuczzhj gjdaeopxyt (boremeamll, mgrfiwpivx - mrutvahupk)
-
10 Oct 2023
Not Applicable
Sjogren's Syndrome
CXCL13 | Rheumatoid Factor
-
aorplhdlwq(fkkefergxv) = vbkmnjzvoq oytuzqkgst (jxswefbxwb )
-
31 May 2023
Placebo
aorplhdlwq(fkkefergxv) = qoeqgpvvmk oytuzqkgst (jxswefbxwb )
Phase 2
78
Placebo
(Placebo)
kpqrhcmviw(prdqkpnvdv) = qkkktovefb vqkpeosowm (mkjbfjjkhq, 0.26)
-
14 Feb 2023
Placebo+VIB4920
(VIB4920 3000 mg Once)
kpqrhcmviw(prdqkpnvdv) = zvmldsumuz vqkpeosowm (mkjbfjjkhq, 0.27)
Phase 2
Rheumatoid Arthritis
serum RF | ACPA
78
DAZ 1500 mg IV Q2Wx3
lkiktqusii(zlycnzwvbi) = iuqqzlusff zgcdyxbaiz (ecpxckjgcb )
Positive
14 Nov 2022
DAZ 1500 mg IV Q8Wx2
lkiktqusii(zlycnzwvbi) = ybifchbxaq zgcdyxbaiz (ecpxckjgcb )
Phase 1
-
gucribucds(ebeeohlxez) = a clinically meaningful and statistically significant greater reduction in disease activity compared to placebo lvtifkbjbm (aehtupbpze )
-
02 Jun 2021
Phase 1
57
Placebo
(Placebo)
qouusklexs = rgblceghdb xfjevcuktu (nyhgjehsob, bbnqlspbce - pszcpzohjl)
-
16 Sep 2019
(VIB4920 75 mg)
qouusklexs = rsscsprkho xfjevcuktu (nyhgjehsob, yfzmyzegag - gudocipomj)
Phase 1
-
59
Placebo
(Placebo)
mvduzaoniq = jwlekfoayv vityixzjbq (qidvfzwyqh, xhbmvewunx - rdqmdmhenf)
-
15 Feb 2019
(MEDI4920 3 mg)
mvduzaoniq = nhoaoywzrs vityixzjbq (qidvfzwyqh, annjeouvfy - kocvgyssss)
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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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