Study on the effect of plasmapheresis combined with high dose of IVIG reduces donor-specific HLA antibody titer to promote donor cell implantation in allogeneic hematopoietic stem cell transplantation

Start Date28 Nov 2023

Sponsor / Collaborator

The General Hospital of Western Theater Command

JPRN-jRCT2041220136

/ RecruitingPhase 3IIT

A multicenter, open-label study to investigate the efficacy and safety of GB-0998 for the treatment of neurological neuropathy in patients with Eosinophilic Granulomatosis with Polyangiitis(EGPA).

Start Date15 Jan 2023

Sponsor / Collaborator-

ChiCTR2200062896

/ SuspendedNot ApplicableIIT

A multicenter study of a short-course blood purification sequential reduction IVIG regimen for the treatment of severe autoimmune diseases

Start Date01 Sep 2022

Sponsor / Collaborator-

100 Clinical Results associated with Human Normal Immunoglobulin (The Japan Blood Products Organization)

100 Translational Medicine associated with Human Normal Immunoglobulin (The Japan Blood Products Organization)

100 Patents (Medical) associated with Human Normal Immunoglobulin (The Japan Blood Products Organization)

8,984

Literatures (Medical) associated with Human Normal Immunoglobulin (The Japan Blood Products Organization)

31 Dec 2025·Hematology

Sustained response off treatment after fostamatinib in refractory immune thrombocytopenia: A series of four case reports

Article

Author: Ghanima, Waleed ; Rackwitz, Stefan ; Lucas Boronat, Francisco Javier ; Carrai, Valentina

INTRODUCTION:

A goal of most primary immune thrombocytopenia (ITP) treatments is reducing or discontinuing treatment while maintaining a response including an absence of bleeding events. We present four cases describing treatment with the spleen tyrosine kinase (SYK) inhibitor, fostamatinib, that showed sustained response off treatment (SROT).

CASE PRESENTATIONS:

Case 1 was a 66-year-old male with chronic ITP. He was pre-treated with prednisone and rituximab before being in the FIT-2 clinical trial (placebo). He received fostamatinib in the FIT-3 open-label extension for seven weeks and maintained SROT for 2.5 years. Case 2 was a 54-year-old female patient with chronic, highly refractory ITP. SROT was achieved after 6 months of fostamatinib and was maintained for more than 16 months (in remission to date). Case 3 was a 60-year-old male with chronic ITP. He was successfully treated with cycles of corticosteroids for six years prior to fostamatinib. He was treated with fostamatinib plus prednisone for approximately two months. SROT was observed in this patient for one year. Case 4 was a 67-year-old male with persistent ITP. Before fostamatinib, he was unresponsive to high-dose dexamethasone, IVIG, eltrombopag and romiplostim. After 11 months of fostamatinib, his dose was tapered for three months and ultimately discontinued. SROT was observed for more than ten months (in remission to date).

DISCUSSION:

These cases emphasize that SROT is achievable with fostamatinib in complex ITP cases unresponsive to multiple previous therapies. Additional research is needed to identify the magnitude of the underlying mechanisms, and the clinical factors associated with, and potentially predictive of, SROT.

31 Dec 2025·Hematology

The costs of treating bleeding episodes in patients with immune thrombocytopaenia in the United Kingdom

Article

Author: McDonald, Vickie ; James, Samuel ; Pochopień, Michał ; Zakrzewski, Maja ; Guterres, Sebastian

OBJECTIVES:

Immune thrombocytopaenia (ITP) is a rare autoimmune disorder characterized by low platelet count and increased risk of bleeding. This study aimed to be the first publication to characterize the economic burden of bleeding events in patients with ITP in the UK.

METHODS:

We performed a microcosting analysis to estimate the costs associated with bleeding events in patients with ITP. Healthcare resources utilized in the management of bleeds of different severity were costed using well-established UK cost sources. The results were validated through semi-structured interviews with clinical experts.

RESULTS:

The severity of bleeding events was classified into four categories, ranging from bleeding managed at home, through mild bleeding managed in the outpatient or day case setting, to serious and life-threatening bleeding events requiring inpatient admission. Total medical costs per event ranged from £2,930 for managing a mild bleeding event, through £16,711 for a serious bleeding event to £32,461 for a life-threatening event. The major cost driver for mild and serious events were intravenous immunoglobulin (IVIg) costs, amounting to £1,614 and £8,071 for the two severity categories, respectively. For life-threatening events, the costs of intensive care unit stay (£9,089) exceeded those of IVIg (£8,071).

CONCLUSION:

Real-world costs of managing bleeding in patients with ITP in the UK are substantial and greater than costs set only based on the UK NHS Tariff. Mitigating the risk of bleeding in patients with ITP is likely to yield not only clinical advantages for patients but also offer substantial cost savings to the health system.

31 Dec 2025·PLATELETS

A case with a novel GATA1 variant mimicking immune thrombocytopenia attacks

Article

Author: Aktekin, Elif Habibe ; Ceylaner, Serdar ; Erbay, Ayşe ; Beşen, Şeyda ; Yazıcı, Nalan

One of the leading thrombocytopenia occasions in childhood is immune thrombocytopenia (ITP). Small number of these patients do not respond to treatment methods known to be effective for ITP such as corticosteroids, intravenous immunoglobulin and thrombopoietin receptor agonists (eltrombopag, romiplostim, etc.) and have serious bleeding symptoms. We present a case in which a molecular genetic analysis was performed due to challenging responses to medical treatment for severe systemic bleeding symptoms which were similar to ITP. A hemizygous variant was detected in the GATA1 gene and a homozygous variant in the ATP2A1 gene for Brody myopathy. Eltrombopag, romiplostim, IVIG and corticosteroid were applied to resistant thrombocytopenia of the patient without knowing the cause. Patient had response in platelet counts in some occasions. This situation attracted our attention after the detection of this GATA variant in the etiopathogenesis of thrombocytopenia. Further investigations should be performed for much more rare causes of thrombocytopenia in patients with refractory thrombocytopenia attacks.

News (Medical) associated with Human Normal Immunoglobulin (The Japan Blood Products Organization)

20 May 2025

·pipelinereview.com

Annexon Showcases Tanruprubart Data Demonstrating Improved Clinical Outcomes in Guillain-Barré Syndrome (GBS) at 2025 Peripheral Nerve Society (PNS) Annual Meeting

First Oral Presentation of the Tanruprubart Real-World Evidence (RWE) Study by International Guillain-Barré Syndrome Outcomes Study (IGOS) Researchers Highlights Benefits over Current Standard of Care in Matched Patient Populations Poster Presentations on New Pivotal Phase 3 Analyses Underscore Tanruprubart’s Rapid and Sustained Treatment Effect and Improvement in Quality of Life Compared to Placebo BRISBANE, CA, USA I May 19, 2025 I Annexon, Inc. (Nasdaq: ANNX), a biopharmaceutical company advancing a late-stage clinical platform of novel therapies for people living with devastating classical complement-mediated neuroinflammatory diseases of the body, brain, and eye, today presented oral and poster presentations highlighting improved outcomes with tanruprubart (formerly ANX005) at the 2025 Peripheral Nerve Society (PNS) Annual Meeting being held May 17-20, 2025 in Edinburgh, UK. GBS is a neuromuscular emergency and rare autoimmune disease that affects at least 150,000 people worldwide each year, with no FDA-approved therapies. In its acute phase, GBS rapidly progresses toward severe weakness that can lead to sudden and complete paralysis, often requiring intensive care and mechanical ventilation. Tanruprubart is a first-in-kind monoclonal antibody designed to block C1q, the initiating molecule of the classical complement cascade, with a single infusion to halt ongoing neuroinflammation and nerve damage in the early phase of GBS to improve and expedite overall recovery. “These compelling clinical results presented at PNS depict how a rapid gain in muscle strength can lead to a better state of health with a single infusion of tanruprubart in a real world setting,” said Henk-André Kroon, M.D., senior vice president of Translational Medicine at Annexon. “Currently, outcomes for GBS patients around the world remain poor, and we are grateful to our collaborators at IGOS for conducting this prespecified analysis showing the significant improvement with tanruprubart compared to standard of care. As the potential first targeted immunotherapy in GBS, we are eager to move tanruprubart forward for patients in need, with the aim of transforming the global treatment landscape for GBS.” RWE Findings Demonstrate Benefits with Tanruprubart over Current Standard of Care in Matched Patient Populations Results of the pivotal Phase 3 trial are reinforced by a RWE study that matched tanruprubart-treated patients from the pivotal Phase 3 trial with patients predominantly from western countries included in the IGOS registry who were treated with current standard of care, intravenous immunoglobulin (IVIg) or plasma exchange (PE). In the RWE study, tanruprubart showed a rapid increase in muscle function resulting in a sustained and more complete recovery compared to IVIg or PE: New Pivotal Phase 3 Trial Analyses Reinforce the Rapid and Sustained Clinical Benefits of a Single Dose of Tanruprubart Presentations are available on the publications page of the company’s website . About Tanruprubart (formerly ANX005) Annexon’s lead investigational therapy, tanruprubart, is a first-of-its kind selective, targeted and rapid-acting agent designed to reduce inflammation and nerve damage by stopping C1q activity in the peripheral and central nervous systems. In GBS, tanruprubart is designed to seek out C1q and prevent its binding to targets on peripheral nerves. Tanruprubart is administered intravenously and has been observed to act almost immediately in blocking C1q function. The aim of an effective treatment in GBS is to rapidly stop the autoimmune damage on nerve cells, allowing patients to regain muscle strength sooner and to regain independence and return to pre-illness activities. Tanruprubart has received both Fast Track and Orphan Drug designations from the U.S. Food and Drug Administration as well as orphan drug designation from the European Medicines Agency for the treatment of GBS. About Guillain-Barré Syndrome (GBS) GBS is a rare neuromuscular emergency resulting from an acute autoantibody and classical complement-mediated attack on peripheral nerves that generally occurs post-infection in otherwise healthy persons. It is an acute, rapidly progressive disease with a narrow timeframe for therapeutic intervention. GBS results in the hospitalization of more than 22,000 people annually in the U.S. and Europe. In its acute phase, the peripheral nerve damage progresses rapidly, causing sudden and complete neuromuscular paralysis that can lead to significant morbidity, disability and mortality. Currently, there are no approved treatments for GBS in the U.S. The long-term disease burden associated with GBS has led to a multi-billion-dollar annual economic cost to the U.S. healthcare system alone. More information about the impact of GBS is available at MoveGBSForward.com . About Annexon Annexon Biosciences (Nasdaq: ANNX) is developing therapeutics that stop classical complement-driven neuroinflammation as first-in-kind treatments for millions of people living with serious neuroinflammatory diseases of the body, brain and eye. Our novel scientific approach focuses on C1q, the initiating molecule of classical complement’s potent inflammatory pathway that when misdirected can lead to tissue damage and loss. By targeting C1q, our immunotherapies are designed to stop this neuroinflammatory cascade in disease before it starts. Our pipeline spans three diverse therapeutic areas – autoimmune, neurodegenerative and ophthalmic diseases – and includes targeted investigational drug candidates designed to address the unmet needs of over 8 million people worldwide. Annexon’s mission is to deliver game-changing therapies to patients so that they can live their best lives. To learn more visit annexonbio.com . SOURCE: Annexon Biosciences

Clinical ResultPhase 3Orphan DrugFast TrackImmunotherapy

14 May 2025

·www.businesswire.com

Nuvig Therapeutics Announces First Patient Dosed in Phase 2 CIDP Trial of NVG-2089 and Presentation of Phase 1 Data

MENLO PARK, Calif.--(BUSINESS WIRE)--Nuvig Therapeutics, Inc. (“Nuvig”), a privately held biotechnology company developing novel immunomodulatory therapeutics for patients with inflammatory autoimmune diseases, today announced that the first patient has been dosed in its Phase 2 clinical trial evaluating NVG-2089 in individuals with chronic inflammatory demyelinating polyneuropathy (CIDP). The company also announced that it will present results from a Phase 1 study of NVG-2089 in healthy volunteers at the 2025 Peripheral Nerve Society (PNS) Annual Meeting on May 19th in Edinburgh, Scotland. “Dosing the first patient in our Phase 2 CIDP trial marks an important step forward in our mission to deliver targeted, mechanism-based immunomodulation for patients with autoimmune diseases,” said Alan Glicklich, M.D., Chief Medical Officer of Nuvig. “Dosing the first patient in our Phase 2 CIDP trial marks an important step forward in our mission to deliver targeted, mechanism-based immunomodulation for patients with autoimmune diseases,” said Alan Glicklich, M.D., Chief Medical Officer of Nuvig Therapeutics. “We are encouraged by the safety and pharmacodynamic data observed in our Phase 1 study and look forward to evaluating NVG-2089 in individuals living with CIDP, a condition that remains underserved by currently available therapies.” The Phase 2 study, called INVGOR, is a multicenter, global trial evaluating the safety, tolerability, and potential clinical benefit of NVG-2089 in up to 60 participants with CIDP. The trial includes patients currently treated with intravenous immunoglobulin (IVIg) who will transition to NVG-2089 and patients who have not previously been treated. The INVGOR trial is being conducted at approximately 40 sites globally. It will evaluate the safety and tolerability of NVG-2089, as well as evaluating the percentage of treatment naive patients achieving evidence of clinical improvement (ECI) at Week 14, and the percentage of IVIg treatment experienced patients achieving ECI at week 14 or stability of disease as measured by adjusted INCAT score between weeks 4 and 14. “There remains a considerable unmet need for CIDP therapies that are effective, non-immunosuppressive, well tolerated, and more convenient than current therapies,” said Jeffrey Allen, M.D., Professor of Neurology at the University of Minnesota Medical School. “We welcome the development of new treatment options such as NVG-2089 that aim to address these limitations and improve patient outcomes.” Presentation of the Phase 1 findings at the upcoming PNS meeting reflects the continued clinical momentum behind NVG-2089. In the Phase 1 study, NVG-2089 was well tolerated, with no serious adverse events, no severe adverse events, and no discontinuations due to adverse events. About NVG-2089 NVG-2089 is a recombinant human IgG1-Fc fusion protein designed to mimic the key immunomodulatory mechanisms of intravenous immunoglobulin (IVIg), the current standard of care for a range of autoimmune diseases. Unlike plasma-derived IVIg, NVG-2089 is produced recombinantly, offering the potential for improved consistency, scalability, and patient convenience. By selectively engaging anti-inflammatory pathways without broadly suppressing the immune system, NVG-2089 is being developed as a next-generation alternative to IVIg with the goal of addressing its limitations in supply, tolerability, and administration burden. About Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) Chronic inflammatory demyelinating polyneuropathy (CIDP) is a neurological autoimmune disorder characterized by progressive weakness and impaired sensory function in the legs and arms. Symptoms typically include symmetrical muscle weakness leading to difficulties with walking, climbing stairs, and performing fine motor tasks. Sensory disturbances such as numbness, tingling, or burning sensations. Additionally, diminished or absent reflexes are a common clinical finding. Fatigue is frequent, significantly impacting the patient’s quality of life. CIDP symptoms can vary in severity and may progress over several months. Diagnosis is typically confirmed through nerve conduction studies, which reveal demyelination, and cerebrospinal fluid analysis showing elevated protein levels. About Nuvig Therapeutics Nuvig Therapeutics is a clinical-stage biotechnology company that is advancing an innovative and transformational pipeline of novel immune therapeutics for chronic inflammatory and autoimmune diseases. The Company’s lead investigational drug candidate, NVG-2089, is an engineered Fc fragment designed to precisely target type II Fc receptors. When NVG-2089 binds to its target, it upregulates the expression of FcgRIIb and causes the expansion of T regulatory cells and the downregulation of numerous inflammatory pathways. Nuvig is based in Menlo Park, California. For more information, please visit www.nuvigtherapeutics.com.

Phase 1ImmunotherapyPhase 2Clinical Result

14 May 2025

·www.prnewswire.com

Hansa Biopharma data at the 2025 PNS Annual Meeting demonstrates potential of imlifidase in the treatment of GBS

LUND, Sweden, May 14, 2025 /PRNewswire/ -- Hansa Biopharma AB, "Hansa" (Nasdaq Stockholm: HNSA), will present data from its 15-HMedIdeS-09 Phase 2 single arm study of imlifidase, a first in class IgG cleaving enzyme, in Guillain-Barré Syndrome (GBS) at the Peripheral Nerve Society (PNS) Annual Meeting, taking place 17-20 May in Edinburgh, Scotland. Hansa communicated the results from the 15-HMedIdeS-09 study in December 2024. Professor Shahram Attarian, Head of Department of Neuromuscular Diseases and ALS, Hopitaux Universitaires de Marseille (APHM) and International Coordinating Principal Investigator will present data from 15-HMedIdeS-09 Phase 2 study at the 2025 PNS Annual Meeting. Hitto Kaufmann, Chief R&D Officer, Hansa Biopharma said, "We are pleased to be able to share more detail around the positive data from our 15-HMedIdeS-09 Phase 2 study, which demonstrated the significant potential imlifidase could have in combination with standard of care IVIg for patients with GBS. We know that IgG is a key driver of inflammatory attacks on peripheral nerves and has been clinically linked to the severity and progression of GBS, and that there is a clear and urgent need for new and faster treatment options in GBS. This data offers meaningful insights to help advance the understanding of IgG in GBS and improve patient care." Hansa's Phase 2 15-HMedIdes-09 open-label, single arm study was performed across multi-centers in the UK, France, and the Netherlands evaluating the safety, tolerability, and efficacy of a single dose of imlifidase (0.25 mg/kg) in 30 adult GBS patients in combination with standard of care (SoC) intravenous immunoglobulin (IVIg). The administration of imlifidase prior to SoC in patients with GBS was considered to be safe and well tolerated. --- ENDS --- Contacts for more information: Evan Ballantyne, Chief Financial Officer [email protected] Stephanie Kenney, VP Global Corporate Affairs [email protected] Notes to editors About imlifidase Imlifidase is a unique antibody-cleaving enzyme originating from Streptococcus pyogenes that specifically targets IgG and inhibits IgG-mediated immune response.1 It has a rapid onset of action, cleaving IgG-antibodies and inhibiting their activity within hours after administration. Imlifidase has conditional marketing approval in Europe and is marketed under the trade name IDEFIRIX® for the desensitization treatment of highly sensitized adult kidney transplant patients with a positive crossmatch against an available deceased donor.1 About imlifidase and autoimmune diseases Autoimmune diseases form a group of serious diseases caused by the immune system attacking the body. In many autoimmune diseases the immune system mistakenly recognizes the body's own proteins, as foreign and mounts an immune response, creating antibodies to attack the body's own cells and tissues.2-4 Pathogenic IgG can contribute to a broad spectrum of autoimmune diseases. Hansa Biopharma is exploring how imlifidase and HNSA-5487 may be able to prevent or slow the progression of these diseases and their debilitating, life-threatening symptoms. Imlifidase is currently being studied in the following autoimmune diseases: anti-glomerular basement membrane (anti-GBM) disease and Guillain-Barré Syndrome (GBS). HNSA-5487 is moving quickly into the clinical phase focusing on patients with myasthenia gravis (MG) and potentially other neuro-autoimmune diseases. About Guillain-Barré Syndrome Guillain-Barré Syndrome (GBS) is a rare, acute, paralyzing, inflammatory disease of the peripheral nervous system caused by the immune system damaging nerve cells and structures. It affects 1-2 in 100,000 people annually.5 In GBS, rapid onset and progression of muscle weakness occurs and can lead to severe paralysis of the arms and legs. Approximately 25 percent of patients require mechanical ventilation for days to months and 20 percent are unable to walk after six months.6-8 Even with current standard of care - either plasma exchange or IVIg therapy - GBS is fatal in 3-7% of cases.6-8 Most GBS patients also have sensory disturbance (tingling or numbness or ataxia) and pain, and some patients have double vision or problems with swallowing. GBS may also involve the respiratory muscles, leading to intensive care unit (ICU) admission and mechanical ventilation.9 About Hansa Biopharma Hansa Biopharma is a pioneering commercial-stage biopharmaceutical company on a mission to develop and commercialize innovative, lifesaving and life-altering treatments for patients with rare immunological conditions. The company has a rich and expanding research and development program based on its proprietary IgG-cleaving enzyme technology platform, to address serious unmet medical needs in autoimmune diseases, gene therapy and transplantation. The company's portfolio includes imlifidase, a first-in-class immunoglobulin G (IgG) antibody-cleaving enzyme therapy, which has been shown to enable kidney transplantation in highly sensitized patients and HNSA-5487, a next-generation IgG cleaving molecule with redosing potential. Hansa Biopharma is based in Lund, Sweden, and has operations in Europe and the U.S. The company is listed on Nasdaq Stockholm under the ticker HNSA. Find out more at and follow us on LinkedIn. ©2025 Hansa Biopharma AB. Hansa Biopharma, the beacon logo, IDEFIRIX, and IDEFIRIX flower logo are trademarks of Hansa Biopharma AB, Lund, Sweden. All rights reserved. References European Medicines Agency. Idefirix® summary of product characteristics. Available at: . Angum F, et al. The Prevalence of Autoimmune Disorders in Women: A Narrative Review. Cureus. 2020 May 13;12(5):e8094. doi: 10.7759/cureus.8094. Wang L, et al. Human autoimmune diseases: a comprehensive update. J Intern Med. 2015 Oct;278(4):369-95. doi: 10.1111/joim.12395. Ma H, Murphy C, Loscher CE and O'Kennedy R (2022) Autoantibodies – enemies, and/or potential allies? Front. Immunol. 13:953726. doi: 10.3389/fimmu.2022.953726 McGrogan A, Madle GC, Seaman HE, de Vries CS. The epidemiology of Guillain-Barré syndrome worldwide. A systematic literature review. Neuroepidemiology. 2009;32(2):150-63. doi: 10.1159/000184748. Epub 2008 Dec 17. PMID: 19088488.Fletcher D, et al. Neurology. 2000 27;54(12):2311-5 Leonhard SE, Papri N, Querol L, Rinaldi S, Shahrizaila N, Jacobs BC. Guillain-Barré syndrome. Nat Rev Dis Primers. 2024 Dec 19;10(1):97. doi: 10.1038/s41572-024-00580-4. PMID: 39702645. Fletcher DD, Lawn ND, Wolter TD, Wijdicks EF. Long-term outcome in patients with Guillain-Barre syndrome requiring mechanical ventilation. Neurology. 2000;54(12):2311–5. van den Berg B, Walgaard C, Drenthen J, Fokke C, Jacobs BC, van Doorn PA. Guillain-Barré syndrome: pathogenesis, diagnosis, treatment and prognosis. Nat Rev Neurol. 2014 Aug;10(8):469-82. doi: 10.1038/nrneurol.2014.121. Epub 2014 Jul 15. PMID: 25023340. Willison HJ, Jacobs BC, van Doorn PA. Guillain-Barré syndrome. Lancet. 2016 Aug 13;388(10045):717-27. doi: 10.1016/S0140-6736(16)00339-1. Epub 2016 Mar 2. PMID: 26948435. This information was brought to you by Cision The following files are available for download: SOURCE Hansa Biopharma AB WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

Phase 2Clinical ResultDrug Approval

100 Deals associated with Human Normal Immunoglobulin (The Japan Blood Products Organization)

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Graft Rejection	Japan	The Japan Blood Products Organization	24 Sep 2024
Guillain-Barre Syndrome	Japan	The Japan Blood Products Organization	08 Feb 2017
Pemphigoid, Bullous	Japan	The Japan Blood Products Organization	27 Jul 2016
Otitis Media	Japan	The Japan Blood Products Organization	02 Feb 2015
Pemphigus	Japan	The Japan Blood Products Organization	05 Aug 2013
Myasthenia Gravis	Japan	The Japan Blood Products Organization	26 Sep 2011
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	Japan	The Japan Blood Products Organization	07 Feb 2011
Dermatomyositis	Japan	The Japan Blood Products Organization	27 Oct 2010
Polymyositis	Japan	The Japan Blood Products Organization	27 Oct 2010
Mucocutaneous Lymph Node Syndrome	Japan	The Japan Blood Products Organization	31 Jan 1996
Agammaglobulinemia	Japan	The Japan Blood Products Organization	28 Jun 1991
Infectious Diseases	Japan	The Japan Blood Products Organization	28 Jun 1991
Purpura, Thrombocytopenic, Idiopathic	Japan	The Japan Blood Products Organization	28 Jun 1991

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Abortion, Habitual	Phase 3	Japan	The Japan Blood Products Organization	03 Jun 2014
Kidney Failure, Chronic	Phase 3	Japan	The Japan Blood Products Organization	01 Nov 2013
Autoimmune Diseases	Preclinical	United States	Vanderbilt University School of Medicine	30 Oct 2012

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


EHA2024	Not Applicable	-	25	IVIG 400mg/kg	eycgkxyeow(wxzsdcwapz) = iaobfukvkp bwkchjkyif (ebyasaxrki, 1 - 000-10 to 500) View more	Positive	14 May 2024
EHA2024	Not Applicable	-	25	Dexamethasone 10mg/m2	eycgkxyeow(wxzsdcwapz) = kdocxqbwpi bwkchjkyif (ebyasaxrki, 1 - 000-10 to 500) View more	Positive	14 May 2024
ASH2023	Not Applicable	Thrombocytopenia	651	IVIG	yrqdupgvpp(xnbaxwqlrs) = fupdavrtxt hgmahmbpmv (oasfwcnbfl ) View more	-	10 Dec 2023
ISN WCN2023	Not Applicable	Polyomavirus Infections	-	IVIG	csmcofbyrh(wfwmiowfcv) = rjzicrxdyh qdirmjwxwy (foabybbuml ) View more	-	01 Mar 2023
ISN WCN2023	Not Applicable	Polyomavirus Infections	-	No IVIG	csmcofbyrh(wfwmiowfcv) = ukxxtpabjs qdirmjwxwy (foabybbuml ) View more	-	01 Mar 2023
AAAAI2023	Not Applicable	decreased IgA levels \| concurrent treatment with an immunomodulating agent \| prior reported drug-allergy ... View more	15	IVIG infusion	ibgxgohpth(cuyalkoibs) = xmxqorjhkp rjacarvoks (ptqdghcvtz )	Positive	01 Feb 2023
AAO2022	Not Applicable	Pain \| Peripheral Nervous System Diseases auto-/dysimmune antibodies	-	IVIG	ofqsduafey(hrcdqlxfsb) = Four patients discontinued treatment before follow-up due to side effects hvqmbkmtng (ornuhughgc ) View more	Positive	29 Sep 2022
AAN2022	Not Applicable	Muscle Weakness	-	IVIG	veetvihbwk(nezbqlmgmn) = eckcubyrst kciquecuta (pkkyjzqdxt, 1.19 - 2.10)	-	03 May 2022
AAN2022	Not Applicable	Muscle Weakness	-	IVIG	rkdbwpjanc(pvqormqqav) = biobfqnzas ibglpwmbaa (kuspkuwumd ) View more	-	03 May 2022
ProCID study (AAN2022)	Not Applicable	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	142	High dose IVIG (2.0g/kg)	lsduqfwqho(olscidvszm) = allergic dermatitis qjunmcogma (cbtxbwfoiu ) View more	-	03 May 2022
AAAAI2022	Not Applicable	Immunologic Deficiency Syndromes	53	PCV13IVIG (PCV13 vaccination)	kjdljmrpce(qifwihlmbm) = xhfdfncvgv elwisggdff (rxhhnnrbhg )	-	01 Feb 2022
AAAAI2022	Not Applicable	Immunologic Deficiency Syndromes	53	PPSV23IVIG (PPSV23 vaccination)	lrvvibcmvn(nwkljcukbi) = mxwvkygllq uhuavwgtgc (txjfrefxxp )	-	01 Feb 2022
P5.2-072 (AAN2019)	Not Applicable	anti-aquaporin 4 (AQP4) antibodies \| anti-myelin oligodendrocyte glycoprotein (MOG) antibodies \| anti-Human 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (HMGCR) antibodies ... View more	-	IVIg preparations	nnbojqnkfu(mdchrfanil) = iynmavvgna brzwcwsyiw (prjhgktrjh, 41 - 816)	-	09 Apr 2019
P4.9-033 (AAN2019)	Not Applicable	West Nile Fever	2	IVIG	dcluwxcjuo(eoffvqwyqg) = Both OMA and MRI changes resolved significantly with 2 sessions of IVIG fmqckkrdtl (mzobdxnahf ) View more	Positive	09 Apr 2019

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