Last update 14 Dec 2024

Salicylic acid

Last update 14 Dec 2024

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

SummarySalicylic acid serves as a precursor to and a metabolite of aspirin, earning it some clout in the pharmaceutical world. It is frequently employed as a topical medication, particularly due to its ability to expel the external layer of skin, which essentially means that it can treat an assortment of skin conditions.

Drug Type

Small molecule drug

Synonyms

2-Carboxyphenol, 2-Hydroxybenzoic acid, O-carboxyphenol

+ [9]

Target

COX

Mechanism

COX inhibitors(Cyclooxygenases inhibitors)

Therapeutic Areas

Immune System DiseasesInfectious DiseasesCongenital Disorders+ [2]

Active Indication

Acne VulgarisDarier DiseaseDermatitis, Atopic+ [12]

Inactive Indication-

Originator Organization

Nichiban Co., Ltd.

Active Organization

Toho Pharmaceutical Co., Ltd.Nichiban Co., Ltd.

Inactive Organization

G. Pohl-Boskamp GmbH & Co. KG

Drug Highest PhaseApproved

First Approval Date

JP (01 Oct 1950),

Skin Diseases

Regulation-

Structure

Molecular FormulaC7H6O3

InChIKeyYGSDEFSMJLZEOE-UHFFFAOYSA-N

CAS Registry69-72-7

Clinical Trials associated with Salicylic acid

ChiCTR2400092514 / SuspendedIIT

The Efficacy and Mechanisms of Fire Needling Combined with 30% Salicylic Acid in the Treatment of Common Acne

Start Date25 Nov 2024

Sponsor / Collaborator-

CTRI/2024/07/071474 / Not yet recruitingNot Applicable

A Clinical Study to Evaluate the Skin Irritation Potential of Mosaic Wellness Hyaluronic Acid Body Wash Mousse and 2percent Salicylic Acid Cleansing Balm on Healthy Human Subjects - NIL

Start Date09 Aug 2024

Sponsor / Collaborator

Mosaic Wellness Pvt Ltd.Startup

CTRI/2024/02/062468 / Not yet recruitingPhase 2/3IIT

Open Randomized Controlled Trial On Erand Patranal Kshar On Mashak With Special Reference to Wart - Nil

Start Date13 Feb 2024

Sponsor / Collaborator-

100 Clinical Results associated with Salicylic acid

100 Translational Medicine associated with Salicylic acid

100 Patents (Medical) associated with Salicylic acid

8,192

Literatures (Medical) associated with Salicylic acid

01 Feb 2025·PLANT SCIENCE

PyWRKY40 negatively regulates anthocyanin synthesis in pear fruit

Article

Author: Yin, Mingxin ; Xu, Mingyang ; Gao, Siyang ; Zhang, He ; Du, Guodong ; Zhang, Xuefeng

The deposition of anthocyanin plays a crucial role in fruit pigmentation and serves as the primary determinant of pear quality. Various factors influence the synthesis of anthocyanins, with salicylic acid playing a significant role among them. However, the mechanism by which salicylic acid affects anthocyanin synthesis remains unclear. Our study identifies the transcription factor PyWRKY40 as a pivotal regulator of SA-mediated anthocyanin synthesis in the nucleus. The negative regulatory function of this factor lies in its ability to suppress anthocyanin synthesis, thereby exerting an influence on fruit coloration. We have confirmed the direct binding of PyWRKY40 to the PyDFR promoter through Y1H and EMSA experiments. The findings elucidate a signaling regulatory module, PyWRKY40-PyDFR, which is responsive to SA and enhances fruit pigmentation by modulating anthocyanin metabolism. This insight offers a viable approach to enhancing fruit coloration and improving the overall quality of pear fruits.

15 Jan 2025·JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Investigation of miniature goat cheese produced from Cynara scolymus L. pistil cell suspension culture extracts elicited with melatonin and salicylic acid

Article

Author: Çayir, Özlem ; Şimşek, Bedia ; Akçay, Ufuk Çelikkol

Abstract:

BACKGROUND:

The present study aimed to evaluate the potential of enzymes produced by artichoke (Cynara scolymus L.) flower cell suspension cultures elicited by melatonin (5 μm) and salicylic acid (50 μm) on the production and characteristics of miniature goat cheeses. In this study, five types of fresh miniature goat cheese were produced using whole artichoke flower extract, salicylic acid (50 μm) or melatonin (5 μm) treated artichoke suspension cell culture extracts, a culture extract without elicitor treatment (control) and rennin enzyme.

RESULTS:

The milk clotting activity values of the enzymes were measured in the range 0.52–0.74. The effect of the enzymes on the titratable acidity, water‐soluble nitrogen, ripening index, αs‐caseins and β‐caseins of goat cheese was significant (P < 0.05). The highest level of casein degradation was observed in the cheese produced with the enzyme containing melatonin, followed by the cheese produced with the enzyme containing salicylic acid.

CONCLUSION:

For the enzymes produced by the suspension cell culture method, the addition of melatonin and salicylic acid had a slightly positive effect on the proteolytic activity of the extracts. It was also found that the enzymes obtained from artichokes by the suspension cell culture method did not achieve successful cheese production in terms of chemical, textural and biochemical aspects compared to those obtained from animal enzymes. © 2024 Society of Chemical Industry.

01 Jan 2025·JOURNAL OF INORGANIC BIOCHEMISTRY

A tale of two old drugs tetracycline and salicylic acid with new perspectives—Coordination chemistry of their Co(II) and Ni(II) complexes, redox activity of Cu(II) complex, and molecular interactions

Article

Author: Xu, Mengsheng ; Yang, Guang ; Islam, Shahedul ; Wang, Le ; Ming, Li-June ; Zheng, Xiaojing ; Eswara, Prahathees ; Suits, Logan ; Su, Xiqi ; Huang, Shaohua ; Cai, Jianfeng ; Xie, Jinhua

Extensive use of the broad-spectrum tetracycline antibiotics (TCs) has resulted their wide spread in the environment and drive new microecological balances, including the infamous antibiotic resistance. TCs require metal ions for their antibiotic activity and resistance via interactions with ribosome and tetracycline repressor TetR, respectively, at specific metal-binding sites. Moreover, the Lewis-acidic metal center(s) in metallo-TCs can interact with Lewis-basic moieties of many bioactive secondary metabolites, which in turn may alter their associated chemical equilibria and biological activities. Thus, it is ultimately important to reveal detailed coordination chemistry of metallo-TC complexes. Herein, we report (a) conclusive specific Co²⁺, Ni²⁺, and Cu²⁺-binding of TC revealed by paramagnetic ¹H NMR, showing different conformations of the coordination and different metal-binding sites in solution and solid state, (b) significant metal-mediated activity of Cu-TC toward catechol oxidation with different mechanisms by air and H₂O₂ (i.e., mono- and di-nuclear pathways, respectively), (c) interactions of metallo-TCs with bioactive salicylic acid and its precursor benzoic acid, and (d) noticeable change of TC antibiotic activity by metal and salicylic acid. The results imply that TCs may play broad and versatile roles in maintaining certain equilibria in microecological environments in addition to their well-established antibiotic activity. We hope the results may foster further exploration of previously unknown metal-mediated activities of metallo-TC complexes and other metalloantibiotics.

News (Medical) associated with Salicylic acid

28 Aug 2024

·www.prnewswire.com

The Chemical Peel Market is projected to grow by USD 814.4 million from 2024 to 2028, driven by rising demand for aesthetic treatments and technological advancements, AI-powered report- Technavio

NEW YORK, Aug. 28, 2024 /PRNewswire/ -- Report on how AI is driving market transformation- The global chemical peel market size is estimated to grow by USD 814.4 millionn from 2024-2028, according to Technavio. The market is estimated to grow at a CAGR of 7.19% during the forecast period. Increasing demand for aesthetic procedures and technological advancement is driving market growth, with a trend towards increasing awareness about anti-aging measures. However, high cost of chemical peel products poses a challenge. Key market players include AbbVie Inc., AMOREPACIFIC Group Inc., Bausch Health Companies Inc., BeautyPharmaCo, Candela Corp., Caudalie International SE, Galderma SA, Hale Cosmeceuticals Inc, Image International Manufacturing LLC, Johnson and Johnson Services Inc., LOreal SA, MedPeel, Merz Pharma GmbH and Co KGaA, NEFTIS LABORATORIOS SL, Pierre Fabre SA, ProDerma Light, Radius Healthcare Pvt. Ltd., Renee Rouleau Inc., Topix Pharmaceuticals Inc., and Unilever PLC. Continue Reading Technavio has announced its latest market research report titled Global chemical peel market 2024-2028 Get a detailed analysis on regions, market segments, customer landscape, and companies - Click for the snapshot of this report Key Market Trends Fueling Growth The chemical peel market is experiencing significant growth due to the increasing awareness and demand for anti-aging procedures. In 2021 and 2022, there has been a rise in the number of cosmetic procedures performed in countries like the US, Brazil, Mexico, Germany, and Spain. This trend is driven by the advantages of chemical peels, including age spot reduction, sun damage removal, skin lightening, smoothening, and improved collagen growth. Vendors are actively promoting these benefits through various channels, such as websites, conferences, and magazine advertisements. Moreover, the increasing per capita income and economic development in emerging economies, particularly India and China, have led to a surge in online research and comparisons of various procedures. As a result, the chemical peel market is poised for continued growth during the forecast period. The Chemical Peel Market is witnessing significant growth due to the increasing demand for non-surgical skincare solutions. Trichloroacetic acid and Jessner's Solution are popular peeling agents used in chemical resurfacing for improving skin texture, reducing hyperpigmentation, acne scars, fine lines, and wrinkle reduction. These treatments are effective for sun damage, melasma treatment, and acne treatment. Medical aesthetics and cosmeceutical treatments using chemical formulations offer clinical benefits for various skin conditions. Glytone, Alpha hydroxy acid (AHA), sugar cane, sugar beets, lactic peel, milk, and Alpha-hydroxy acids (AHAs) are common peeling agents. Medium peels target the epidermis and dermis layers for enhanced skin health and beauty. The chemical peel procedure is a dermatologic treatment for skin health improvement and aesthetic enhancement. Discover a Comprehensive 360° Market Analysis: Understand the Impact of AI. For detailed information- Request Sample! Market Challenges The chemical peel market is currently facing a growth challenge due to the high cost of treatments, which is limiting its adoption, particularly in developing countries. The average price for a chemical peel ranges from USD600 to USD900, with significant variations depending on the type of peel. Light peels cost as low as USD150 but require multiple sessions for optimal results, while medium and deep peels can cost up to USD6,000. These high costs include fees for the chemical peel procedure, anesthesia, and operating room. The monopolistic approach of vendors, such as Allergan plc, in the market further contributes to the lack of competitive pricing. Allergan, a leading player in medical aesthetics, has acquired most of the market share, targeting high-income and upper-middle-class consumers. As a result, the inability of middle and lower-middle-class individuals to afford these costly procedures is hindering the growth of the global chemical peel market. The Chemical Peel market is thriving in the Skincare and Aesthetics industries, providing solutions for common concerns such as Acne, Pigmentation, and Wrinkle issues. Glytone's Peeling Solution, which contains Alpha Hydroxy Acids (AHAs) derived from Sugar Cane and Sugar Beets, is a popular choice for exfoliating the Epidermis. Medium Peels, using stronger Chemical Agents like TCA, reach deeper into the Dermis to address Acne spots, Dark Circles, and signs of Fatigue. Dermatology and Aesthetic Medicine professionals use these Dermatological Procedures for Skin Renewal, often combining different Chemical Compounds like Glycolic Acid, Lactic Acid, and Salicylic Acid for optimal results. The Beauty Industry continues to innovate with new Peeling Solutions, offering professional Chemical Exfoliation treatments for Facial Rejuvenation. For more insights on driver and challenges - Download a Sample Report Segment Overview This chemical peel market report extensively covers market segmentation by End-user 1.1 Hospital and recreation centers 1.2 Dermatology clinics Type 2.1 Light peel 2.2 Medium peel 2.3 Deep peel Geography 3.1 North America 3.2 Europe 3.3 APAC 3.4 South America 3.5 Middle East and Africa 1.1 Hospital and recreation centers- The Chemical Peel Market is experiencing steady growth due to increasing consumer awareness and demand for skin rejuvenation treatments. Businesses are offering various types of chemical peels to cater to diverse skin concerns, such as acne scars, aging, and sun damage. Market leaders are focusing on research and development to introduce innovative peel solutions and expand their customer base. Overall, the market is expected to continue its expansion in the coming years.For more information on market segmentation with geographical analysis including forecast (2024-2028) and historic data (2018 - 2022) - Download a Sample Report Research Analysis The Chemical Peel market encompasses a range of skincare treatments used in aesthetics to address various skin concerns, including acne, pigmentation, and wrinkle issues. These peels work by applying a chemical solution to the skin, causing it to exfoliate and peel off, revealing smoother, fresher skin. The solutions typically contain Alpha-hydroxy acids (AHAs) derived from fruits like glycolic acid from sugar cane and lactic peels from milk. Deeper peels may involve Phenol or Trichloroacetic acid, reaching the dermis for more significant results. Acne spots, dark circles, and signs of fatigue can also be targeted. Genetics and collagen production play a role in skin health, making chemical peels a popular choice for those seeking to improve their complexion in dermatology practices. Market Research Overview The Chemical Peel market encompasses a range of skincare treatments that utilize chemical solutions to improve the appearance of the skin. These peels are commonly used for various aesthetic concerns such as acne, pigmentation, and wrinkle issues. The solutions typically contain Alpha Hydroxy Acids (AHAs) derived from fruits like sugar cane and sugar beets, or Beta Hydroxy Acids (BHAs) like Salicylic Acid. The depth of the peel can vary from light to medium, affecting the epidermis or dermis layers. Chemical Peels are used to address acne spots, dark circles, fatigue, and signs of aging such as fine lines and wrinkles. The causes of these conditions can stem from genetics, sun damage, or lifestyle factors. The treatments promote collagen production, leading to skin renewal and texture improvement. Chemical Peels are considered a dermatological procedure and are also offered in aesthetic medicine clinics and the beauty industry. They provide a form of chemical exfoliation that goes beyond traditional cleansing methods. The solutions work by dissolving the bonds holding dead skin cells together, revealing smoother, healthier skin. Popular chemical peel formulations include Glytone, Jessner's Solution, TCA Peel, and various combinations of AHAs and BHAs. These treatments are administered as facial treatments in professional settings and are an essential part of medical aesthetics and cosmeceutical offerings. Chemical Peels contribute to skin health and beauty enhancement, addressing various skin conditions and concerns. They are an effective means of reducing hyperpigmentation, acne scars, sun damage, and melasma. The cosmetic procedure is a popular choice for individuals seeking wrinkle reduction and skin rejuvenation. Table of Contents: 1 Executive Summary 2 Market Landscape 3 Market Sizing 4 Historic Market Size 5 Five Forces Analysis 6 Market Segmentation End-user Hospital And Recreation Centers Dermatology Clinics Type Light Peel Medium Peel Deep Peel Geography North America Europe APAC South America Middle East And Africa 7 Customer Landscape 8 Geographic Landscape 9 Drivers, Challenges, and Trends 10 Company Landscape 11 Company Analysis 12 Appendix About Technavio Technavio is a leading global technology research and advisory company. Their research and analysis focuses on emerging market trends and provides actionable insights to help businesses identify market opportunities and develop effective strategies to optimize their market positions. With over 500 specialized analysts, Technavio's report library consists of more than 17,000 reports and counting, covering 800 technologies, spanning across 50 countries. Their client base consists of enterprises of all sizes, including more than 100 Fortune 500 companies. This growing client base relies on Technavio's comprehensive coverage, extensive research, and actionable market insights to identify opportunities in existing and potential markets and assess their competitive positions within changing market scenarios. Contacts Technavio Research Jesse Maida Media & Marketing Executive US: +1 844 364 1100 UK: +44 203 893 3200 Email: [email protected] Website: SOURCE Technavio

30 Jul 2024

·www.drugs.com

FDA Warns Against Purchasing or Using Chemical Peel Skin Products Without Professional Supervision

Audience: Consumer July 30, 2024 -- FDA is warning consumers not to purchase or use certain chemical peel skin products without appropriate professional supervision due to risk of serious skin injuries. The agency has not approved any chemical peel products, and consumers should only consider using chemical peel products under the supervision of a dermatologist or licensed and trained practitioner. Many of these chemical peel products are sold in beauty product stores and online and marketed for purposes such as acne, discoloration, wrinkles, and collagen production. They contain ingredients such as trichloroacetic acid (TCA), glycolic acid, salicylic acid and lactic acid in varying concentrations that are too high to be used safely at home without supervision by a dermatologist or other licensed and trained practitioner. Using products that contain high concentrations of these acids may lead to serious injury from chemical burns. The concentration, number of applications, and length of time a chemical peel product is left on the skin all influence how deeply it can penetrate skin layers and potentially lead to chemical burns. These products remove layers of skin to varying depths and may cause severe chemical burns, pain, swelling, infection, skin color changes, and disfiguring scars. These injuries may even require emergency care or specialty care from a dermatologist or surgeon. FDA has issued warning letters to the following companies for selling these products: FDA encourages health care professionals and consumers to report adverse events or quality problems with these or any medications to FDA’s MedWatch Adverse Event Reporting program: Source: FDA Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

01 May 2024

·www.sciencedaily.com

Novel genetic plant regeneration approach without the application of phytohormones

Conventional plant regeneration approaches by cell culture require the external application of plant growth regulators, including hormones. However, optimizing culture conditions can be laborious. Now, researchers have developed a novel plant regeneration system that omits the need for hormone application by genetically regulating the expression of genes that control plant cell differentiation. Their work holds significant potential in the development of genetically modified plants in a simpler and cost-effective manner. Conventional plant regeneration approaches by cell culture require the external application of plant growth regulators, including hormones. However, optimizing culture conditions can be laborious. Now, researchers have developed a novel plant regeneration system that omits the need for hormone application by genetically regulating the expression of genes that control plant cell differentiation. Their work holds significant potential in the development of genetically modified plants in a simpler and cost-effective manner. For ages now, plants have been the primary source of nutrition for animals and humankind. Additionally, plants are used for the extraction of various medicinal and therapeutic compounds. However, their indiscriminate use, along with the rising demand for food, underscores the need for novel plant breeding practices. Advances in plant biotechnology can address the problems associated with food scarcity in the future by enabling the production of genetically modified (GM) plants with higher productivity and resilience to the changing climate. Naturally, plants can regenerate an entire new plant from a single 'totipotent' cell (a cell that can give rise to multiple cell types) through dedifferentiation and redifferentiation into cells with various structures and functions. Artificial regulation of such totipotent cells through plant tissue culture is widely used for plant conservation, breeding, generation of GM species, and scientific research purposes. Conventionally, tissue culture for plant regeneration requires the application of plant growth regulators (PGRs), such as auxins and cytokinins, to control cell differentiation. However, optimum hormone conditions can vary significantly with plant species, culture conditions, and tissue type. Therefore, establishing optimum PGR conditions can be time-consuming and laborious. To overcome this challenge, Associate Professor Tomoko Igawa, along with Associate Professor Mai F. Minamikawa from Chiba University, Professor Hitoshi Sakakibara from the Graduate School of Bioagricultural Sciences, Nagoya University, and Expert Technician Mikiko Kojima from RIKEN CSRS, have developed a versatile method of plant regeneration by modulating the expression of 'developmental regulator' (DR) genes which control plant cell differentiation. Giving further insights into their research work published on 3 April 2024 in Volume 15 of Frontiers in Plant Science, Dr. Igawa says, "Instead of using external PGRs, our system uses the DR genes, which are involved in development and morphogenesis, to control cellular differentiation. The system utilizes transcription factor genes and resembles induced pluripotent cell generation in mammals." The researchers ectopically expressed two DR genes, namely -- BABY BOOM (BBM) and WUSCHEL (WUS) from Arabidopsis thaliana (used as the model plant), and examined their effects on the differentiation of tobacco, lettuce, and petunia tissue cultures. BBM encodes a transcription factor that regulates embryonic development, while WUS encodes a transcription factor that maintains stem cell identity in the shoot apical meristem region. Their experiments revealed that the expression of Arabidopsis BBM or WUS alone was insufficient to induce cell differentiation in tobacco leaf tissue. Conversely, co-expression of functionally enhanced BBM and functionally modified WUS induced an accelerated and autonomous differentiation phenotype. The transgenic leaf cells differentiated into calli (a disorganized mass of cells), greenish organ-like structures, and adventitious shoots in the absence of PGR application. Quantitative polymerase chain reaction (qPCR) analysis (a technique used to quantify gene transcripts) revealed that the expression of Arabidopsis BBM and WUS was associated with the formation of transgenic calli and shoots. Given the key role of phytohormones in cell division and differentiation, the researchers went on to quantify the levels of six phytohormones, namely -- auxins, cytokinins, abscisic acid (ABA), gibberellins (GAs), jasmonic acid (JA), salicylic acid (SA), and their metabolites in the transgenic plant cultures. Their findings revealed that the levels of active auxins, cytokinins, ABA, and inactive GAs increased as cells differentiated to form organs, highlighting their role in plant cell differentiation and organogenesis. Furthermore, the researchers used transcriptome by RNA sequencing (a technique used for qualitative and quantitative analysis of gene expression) to assess the gene expression patterns in the transgenic cells showing active differentiation. Their results suggested that genes related to cell proliferation and auxins were enriched among the differentially upregulated genes. Further validation using qPCR revealed that four genes were upregulated or downregulated in the transgenic cells, including those regulating plant cell differentiation, metabolism, organogenesis, and auxin response. Overall, these findings shed light on the novel and versatile approach to plant regeneration without the need for externally applying PGR. Moreover, the system used in this study has the potential to advance our understanding of the fundamental processes of plant cell differentiation and improve the biotechnological breeding of useful plant species. Highlighting the applications of their work, Dr. Igawa remarks, "The reported system can improve plant breeding by providing a tool to induce cellular differentiation of GM plant cells without PGR application. Therefore, in societies where GM plants are accepted as products, it would accelerate plant breeding and reduce associated production costs."

100 Deals associated with Salicylic acid

External Link

KEGG	Wiki	ATC	Drug Bank
D00097	Salicylic acid	S01BC08 D01AE12	DB00936

R&D Status

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Acne Vulgaris	JP	Toho Pharmaceutical Co., Ltd.	20 Dec 2023
Darier Disease	JP	Toho Pharmaceutical Co., Ltd.	20 Dec 2023
Dermatitis, Atopic	JP	Toho Pharmaceutical Co., Ltd.	20 Dec 2023
Dermatitis, Perioral	JP	Toho Pharmaceutical Co., Ltd.	20 Dec 2023
Eczema	JP	Toho Pharmaceutical Co., Ltd.	20 Dec 2023
Hyperhidrosis	JP	Toho Pharmaceutical Co., Ltd.	20 Dec 2023
Impetigo	JP	Toho Pharmaceutical Co., Ltd.	20 Dec 2023
Keratoderma, Palmoplantar	JP	Toho Pharmaceutical Co., Ltd.	20 Dec 2023
Odour body	JP	Toho Pharmaceutical Co., Ltd.	20 Dec 2023
Pityriasis Rubra Pilaris	JP	Toho Pharmaceutical Co., Ltd.	20 Dec 2023
Psoriasis	JP	Toho Pharmaceutical Co., Ltd.	20 Dec 2023
tinea cruris	JP	Toho Pharmaceutical Co., Ltd.	20 Dec 2023
Tinea Versicolor	JP	Toho Pharmaceutical Co., Ltd.	20 Dec 2023
Warts	JP	Nichiban Co., Ltd.	29 Jul 1985
Skin Diseases	JP	Nichiban Co., Ltd.	01 Oct 1950

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


EADV2023	Not Applicable	Acne Vulgaris	60	16.7% salicylic acid and 16.7% lactic acid in collodion base	bwqbrdprlv(vvsnuxduur) = Mild burning, erythema and exfoliation was seen in 31.6% of patients prmwhbzhey (cpgesduolh )	Positive	11 Oct 2023
EADV2022	Not Applicable	Dandruff	100	SeS 2 -1% salicylic acid shampoo	srawvsertq(xwxtesedaq) = ewvfffzdpw skgrbrgjxc (tqnwvnqlpl )	-	07 Sep 2022
NCT01237821 (CTgov)	Not Applicable	Acne Vulgaris	66	Effaclar (Effaclar)	ijacfavorj(bxftvsgjfj) = wdlbjlqrsi caceovyayz (bqdaboxnbo, sizhdlejdu - rhmpfbzyia) View more	-	16 Jul 2019
NCT01237821 (CTgov)	Not Applicable	Acne Vulgaris	66	BenzaClin (Benzaclin)	ijacfavorj(bxftvsgjfj) = cvbuxsffpb caceovyayz (bqdaboxnbo, thibwwiowx - btvdtegvvc) View more	-	16 Jul 2019
NCT01706263 (CTgov)	Phase 4	Acne Vulgaris	28	MAXCLARITY II (0.5% Salicylic Acid) Toner Foam+MAXCLARITY II (2.5% BPO) Foam Treatment	wiexvromfx(ahvwjgxkue) = ouuufqqibl hubutxsniv (fhgzqrxjmo, gtfjyrkkdp - dsbcfrfyws) View more	-	08 Jan 2018
NCT00848744 (CTgov)	Not Applicable	Acne Vulgaris	10	salicylic acid (Salicylic Acid)	coqmpkyjar(xzittuccmt) = vhxzszpqru volbqhnkdm (opoeinsmpe, qbfoqyreuq - gphehrhcve) View more	-	05 Jul 2010
NCT00848744 (CTgov)	Not Applicable	Acne Vulgaris	10	salicylic acid (Formulation B)	coqmpkyjar(xzittuccmt) = dzqkdpzaud volbqhnkdm (opoeinsmpe, kjnyutrubj - wsvqdibkxa) View more	-	05 Jul 2010
ARVO2003	Not Applicable	-	-	Salicylic acid	dqdqjlfjin(btklfwfhvm) = ckuddogoiq lminvamino (wkmnhdjmoo ) View more	Positive	01 May 2003

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