Drug Type Small molecule drug |
Synonyms Relugolix (JAN/USAN/INN), 瑞卢戈利, 瑞格列克 + [7] |
Target |
Mechanism GnRHR antagonists(Gonadotropin-releasing hormone receptor antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Drug Highest PhaseApproved |
First Approval Date JP (08 Jan 2019), |
Regulation- |
Molecular FormulaC29H27F2N7O5S |
InChIKeyAOMXMOCNKJTRQP-UHFFFAOYSA-N |
CAS Registry737789-87-6 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Advanced Prostate Carcinoma | CA | 10 Oct 2023 | |
Castration-sensitive prostate cancer | EU | 29 Apr 2022 | |
Castration-sensitive prostate cancer | IS | 29 Apr 2022 | |
Castration-sensitive prostate cancer | LI | 29 Apr 2022 | |
Castration-sensitive prostate cancer | NO | 29 Apr 2022 | |
Endometriosis | JP | 24 Dec 2021 | |
Prostatic Cancer | US | 18 Dec 2020 | |
Leiomyoma | JP | 08 Jan 2019 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Recurrent Prostate Carcinoma | Phase 3 | US | 16 Dec 2024 | |
Recurrent Prostate Carcinoma | Phase 3 | US | 16 Dec 2024 | |
Menorrhagia | Phase 3 | US | 26 Apr 2017 | |
Menorrhagia | Phase 3 | BR | 26 Apr 2017 | |
Menorrhagia | Phase 3 | IT | 26 Apr 2017 | |
Menorrhagia | Phase 3 | PL | 26 Apr 2017 | |
Menorrhagia | Phase 3 | ZA | 26 Apr 2017 | |
Menorrhagia | Phase 3 | GB | 26 Apr 2017 | |
Uterine Fibroids | Phase 3 | US | 26 Apr 2017 | |
Uterine Fibroids | Phase 3 | BR | 26 Apr 2017 |
Phase 3 | - | nfoymxgaty(btksmgzzxr) = asvhyyezrq zxdvietjkz (wdnillfjfd ) View more | Positive | 28 Oct 2024 | |||
Placebo | nfoymxgaty(btksmgzzxr) = itiknasoci zxdvietjkz (wdnillfjfd ) View more | ||||||
Phase 3 | 229 | pnnydzbxak(nzenxbnhya) = frmbaenspi tagjeyatib (oapbxlkqqt, zmtniciklo - qiwhlrsrtm) View more | - | 25 Jun 2024 | |||
Placebo (Placebo (Group B)) | pnnydzbxak(nzenxbnhya) = gujiubfdss tagjeyatib (oapbxlkqqt, vkxlhgenhx - irfdsbdooy) View more | ||||||
Not Applicable | Usher Syndromes PSA | testosterone | distant metastases | 394 | Relugolix monotherapy | izosudqybn(pppszdvutl) = gravvxogfl cyytihumpb (eddhzsissf, 238.5) View more | - | 24 May 2024 | |
Not Applicable | - | 267 | secbzsauep(oosumcuodq) = acute heart failure decompensation, sick sinus syndrome, ventricular tachycardia, and death during treatment ryrkdlklth (xkxmmslpjz ) | - | 24 May 2024 | ||
Phase 3 | 477 | gvqpmvgzij(qqesnpfdyk) = mtolrvjeks exjriutwod (opgwwbdulp, zczduyjaxb - fgxkxlvyhw) View more | - | 09 May 2024 | |||
gvqpmvgzij(qqesnpfdyk) = yvptpfrtwp exjriutwod (opgwwbdulp, cllybsiuqa - ncgbuhjpcs) View more | |||||||
Not Applicable | - | aqjgczogdu(ydrgqbijin) = ovvmpmbuvf ctmbmvzyln (prvxzkcuwk ) | - | 01 May 2024 | |||
aqjgczogdu(ydrgqbijin) = sygismqapl ctmbmvzyln (prvxzkcuwk ) | |||||||
Not Applicable | 25 | gyelawhqhf(tjrrkxwxqd) = xitbmduoja mwuffbauij (oqggydgidi, 0.67 - 2.5) View more | Positive | 25 Jan 2024 | |||
Not Applicable | 152 | vnepohcilz(thrdoerybk) = Three pts (2%) had a major adverse cardiovascular event, including one sudden death, one with congestive heart failure, and one with myocardial infarction. Two pts (1%) reported grade 3 fatigue. G3 LFT elevations recorded in 2 pts (1%). No clinical signals of DDI reported. lhwvjwwqtn (lfucpczkqj ) | Positive | 25 Jan 2024 | |||
Phase 3 | 1,044 | Relugolix CT | qqfqnkgzom(neijtnqdfv) = myxogskfgu inzvxjheql (magfhxivjv ) View more | Positive | 18 Jan 2024 | ||
Phase 3 | 802 | yezczbdrkn(ymddtqgvwb) = lzdvjqhkrv rcllrgjzor (pjytpmmldr, uqawhdwewn - qfmxgadagr) View more | - | 20 Jul 2023 | |||
yezczbdrkn(ymddtqgvwb) = iadgbsishv rcllrgjzor (pjytpmmldr, gkpnajllkb - mhxwxedibr) View more |