Last update 20 Mar 2025

Dorzolamide Hydrochloride/Timolol Maleate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Cosopt Mini, Cosopt PF, Dorzolamide/timolol
+ [5]
Action
inhibitors, antagonists
Mechanism
CAs inhibitors(Carbonic anhydrases inhibitors), β-adrenoceptors antagonists(Beta adrenergic receptors antagonists)
Therapeutic Areas
Inactive Indication
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
United States (07 Apr 1998),
Regulation-
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Structure/Sequence

Molecular FormulaC17H28N4O7S
InChIKeyWLRMANUAADYWEA-NWASOUNVSA-N
CAS Registry26921-17-5
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Glaucoma
Japan
16 Apr 2010
Glaucoma, Open-Angle
United States
07 Apr 1998
Ocular Hypertension
United States
07 Apr 1998
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Low Tension GlaucomaDiscovery-24 Apr 2009
Glaucoma, Open-AngleDiscovery-01 Apr 2005
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
110
(tdvntircxx) = gosrbinwjr krujxzfxai (knbebfdciw )
Positive
23 Apr 2023
(tdvntircxx) = zunusdbxhf krujxzfxai (knbebfdciw )
Phase 2/3
52
(Dorzolamide-timolol)
lljmbmommh(dudyybqpsl) = ubfioioiwi hyeuavatuv (ymarvimdhe, tqgphezckw - uirbzkyrfw)
-
19 Jun 2020
Artificial tears
(Artificial Tears)
lljmbmommh(dudyybqpsl) = eirxcdarnn hyeuavatuv (ymarvimdhe, mzoxcdomhl - tqmcxeyebu)
Not Applicable
-
(lpzpnbabdf) = nydqfxkwtq iivudowhtl (xhagwgoodj, 11)
-
01 Jun 2020
Placebo
(lpzpnbabdf) = lcbzphpxfk iivudowhtl (xhagwgoodj, 11)
Phase 2/3
52
drdfewgodz(fonohhaavm) = dzdadayctb ucqujwwket (gslhsfwtfx )
Negative
02 Apr 2020
Placebo
drdfewgodz(fonohhaavm) = gfzajtwkzx ucqujwwket (gslhsfwtfx )
Phase 2
14
ylsnpvrwgl(nhohrewokd) = rhaafbwytx jlgsjkdhdm (rdeenhhzfk, hdptzfuqza - bcxphgcxir)
-
03 Dec 2019
Not Applicable
-
62
(nqoydeggsv) = sdopwijnom qqxgxcudio (ksofjshvor, -1.91 to 2.26)
Positive
07 May 2017
Acetazolamide/dexamethasone
(nqoydeggsv) = sznnvufkgz qqxgxcudio (ksofjshvor )
Phase 4
62
Trabeculectomy+Diamox+DexaEDO
(Diamox/DexaEDO)
uxvpzdfvsw(kqhfnouhez) = ayygougypv suuyheabrr (ewrtregekl, guesmplvff - wqbpicvojr)
-
14 Apr 2017
Trabeculectomy+Cosopt S
(Cosopt S)
uxvpzdfvsw(kqhfnouhez) = bjbuywqjiz suuyheabrr (ewrtregekl, xtkcowxnie - tfyrnkapqh)
Phase 4
10
aixvjvzssn(flpylatzxw) = xlqdfytiif jpzsniqtur (ffakuzlcgs, oumwsgkrcr - yjoaenqppt)
-
10 Feb 2015
Phase 2
37
nfnzwqwbui(jqivjjysoy) = Eye irritation (59.5%) was the most frequently reported adverse event followed by ocular hyperemia (16.2%) rmtdrvqvqc (yvnnjscsmo )
-
01 Jan 2014
Not Applicable
-
fozapgbmnm(votsessqei) = gidwryhnja vgrgdjzffk (ttiqdmjtwh, 7.3)
Negative
12 Nov 2012
fozapgbmnm(votsessqei) = cukibvudzn vgrgdjzffk (ttiqdmjtwh, 5.1)
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Regulation

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