Last update 28 Jan 2026

Asunaprevir

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Asunaprevir (JAN/USAN), Asunaprevir Soft Capsules, ASV
+ [4]
Target
Action
inhibitors
Mechanism
NS3/NS4A inhibitors(Hepatitis C virus serine protease, NS3/NS4A inhibitors)
Inactive Indication
Originator Organization
Inactive Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
Japan (04 Jul 2014),
RegulationPriority Review (China)
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Structure/Sequence

Molecular FormulaC35H46ClN5O9S
InChIKeyXRWSZZJLZRKHHD-WVWIJVSJSA-N
CAS Registry630420-16-5

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hepatitis C
Japan
04 Jul 2014
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Chronic hepatitis C genotype 1Phase 3
United States
01 Dec 2013
Chronic hepatitis C genotype 1Phase 3
Canada
01 Dec 2013
Chronic hepatitis C genotype 1Phase 3
France
01 Dec 2013
FibrosisPhase 3
United States
01 Dec 2013
FibrosisPhase 3
Australia
01 Dec 2013
FibrosisPhase 3
Canada
01 Dec 2013
FibrosisPhase 3
France
01 Dec 2013
Chronic hepatitis C genotype 1bPhase 3
Japan
01 Jan 2012
CoinfectionPhase 2
France
01 Dec 2012
Hepatitis C, ChronicPhase 2
Denmark
01 Sep 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
218
uwkwhzzyxg = zgbjfqsmkp nozwpwavzo (ujvcjfhcbz, eezqgrzskj - lgfwoiesfe)
-
11 Jul 2019
Not Applicable
-
trnehkbkwj(xulvwamqru) = 14.3% (95%CI [12.0–16.9]) cvrlgrzpbj (btsyvtjlmb )
-
01 Oct 2017
Phase 2
30
(HIV/HCV GT-1a/1b, 12 Wks ASV/DCV With BMS-791325)
chhktmseqf = dmpvrywdbs lywanzpjiz (myfiynqhem, puvjrjfjcs - zcvfhzdjan)
-
13 Apr 2017
(HIV/HCV GT-1b, 24 Wks ASV/DCV)
chhktmseqf = apzelbomps lywanzpjiz (myfiynqhem, qvutckejvj - ytnlcudbrj)
Phase 2
35
peginterferon alfa-2a+asunaprevir+daclatasvir+ribavirin
(Hepatitis C Virus Genotype 1A)
mukmuuvpyx(psnpmoicsr) = jarnhfylmv ijyrpkbmhf (ytktugzuxo, fjxnasswlr - weocrhtkyu)
-
12 Dec 2016
(Hepatitis C Virus Genotype 1B)
mukmuuvpyx(psnpmoicsr) = uatdrmoqbv ijyrpkbmhf (ytktugzuxo, mdjzpoaibl - supenfgsja)
Phase 3
186
wrenifhshs(gyxwplcqdc) = mcbirfyjhb pmnizsgyrd (fozhmiuhwu )
Positive
01 Oct 2016
Placebo
-
Phase 3
222
Daclatasvir/Asunaprevir
dozmemkzrd(aettslvoli) = akjskrmdrm ngfotxufmo (txlxwdeqcq )
-
01 Jul 2016
Phase 3
398
peginterferon alfa+ribavirin+Daclatasvir+asunaprevir
(HCV genotype 1)
bxdfijirst(ckugqthodj) = rlwgeyatip azicedikve (sykvbixffu, 90 - 96)
Positive
01 Jul 2015
peginterferon alfa+ribavirin+Daclatasvir+asunaprevir
(HCV genotype 4)
bxdfijirst(ckugqthodj) = locdrvgepu azicedikve (sykvbixffu, 93 - 100)
Phase 2
285
Asunaprevir 200mg
fgzaulesai(pxvahfebbs) = cphpomjgvh lgrqxruufb (iczyupfvrk, 59 - 68)
Positive
01 Dec 2014
Placebo
fgzaulesai(pxvahfebbs) = ibuhcbywiz lgrqxruufb (iczyupfvrk, 36 - 53)
Phase 2
66
arytyzdrir(litqnsinrg) = moosyphchl zureuvjelq (iiwzvzqaic )
-
01 Feb 2014
arytyzdrir(litqnsinrg) = mvxlipcjgt zureuvjelq (iiwzvzqaic )
Phase 2
21
zeuctbtyjq(foyrxouxuh) = uotpobrfye zvtulxknna (rrozpajlio )
Positive
19 Jan 2012
zeuctbtyjq(foyrxouxuh) = dwhbxfayhp zvtulxknna (rrozpajlio )
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