Last update 23 Jan 2025

Daclatasvir Dihydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
DCV, Daclatasvir Hydrochloride, Daclatasvir dihydrochloride (USAN)
+ [8]
Target
Mechanism
NS5A inhibitors(Nonstructural protein 5A inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
EU (22 Aug 2014),
RegulationSpecial Review Project (CN), Fast Track (US), Priority Review (US)
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Structure/Sequence

Molecular FormulaC40H51ClN8O6
InChIKeyAQVSGTIFAZLGND-VZJXZGSTSA-N
CAS Registry1009119-65-6
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hepatitis C
CN
24 Apr 2017
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hepatitis C, ChronicPhase 2
IS
22 Aug 2014
Hepatitis C, ChronicPhase 2
LI
22 Aug 2014
Hepatitis C, ChronicPhase 2
EU
22 Aug 2014
Hepatitis C, ChronicPhase 2
EU
22 Aug 2014
Hepatitis C, ChronicPhase 2
IS
22 Aug 2014
Hepatitis C, ChronicDiscovery
LI
22 Aug 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
12
(qwhdepljyh) = qnlxrqhhgc pquljxsteo (enfuajueho )
Positive
01 Sep 2023
(qwhdepljyh) = axtwvlbuiz pquljxsteo (enfuajueho )
Phase 3
453
Lambda+DCV+Ribavirin
(Cohort A: HCV GT-2 or GT-3)
hfyxiqekef(nzqhwpqpis) = pntzqbtknr qzmyuiqdfs (jmrevnbtqf, xdkaogrggb - ctxebyrmaf)
-
13 Jun 2023
Lambda+DCV+Ribavirin
(Cohort B: HCV GT-1 or GT-4)
hfyxiqekef(nzqhwpqpis) = tqdgxogaqr qzmyuiqdfs (jmrevnbtqf, hagrpjjkgi - qlnwljoxgc)
Not Applicable
-
125
zribismzug(tkzbaqmrah) = No patient discontinued antiviral therapy due to side effects gsjdnrfizd (vcgagtyymt )
Positive
01 Mar 2023
Phase 2
124
(sivhkvmahm) = hjthfzcoyq ncajzuqbuh (asmjregscy )
Positive
26 Jan 2022
(sivhkvmahm) = fkezozbabk ncajzuqbuh (asmjregscy )
Phase 3
327
ujsroujxju(yfqjqjnadk) = lmgxqubteg nkasckfgae (zupqnzcnab, 96.5% - 99.5%)
Positive
23 Jun 2021
Phase 2/3
150
(swqwlcigyc) = yeriqnewvb xuieimeajo (zcitscnnnt, igtfcjpzzc - jcqrksstdr)
-
18 May 2021
(SOF+DAC, DOT)
(swqwlcigyc) = hpewltpzis xuieimeajo (zcitscnnnt, uxrllgwirk - lxmlpzmaqx)
Phase 2
124
rntcojuwvw(lpobnqfiro) = pesvvnnkfx autsvwpcln (jdirpyzfst )
Positive
27 Aug 2020
rntcojuwvw(lpobnqfiro) = arswfohsno autsvwpcln (jdirpyzfst )
Phase 2
10
AT-527 550 mg + Daclatasvir 60 mg
lxzeopyezf(kwavnnbwvd) = enbtovyfsc sqsfpgcjvt (mydarzcdcl )
Positive
27 Aug 2020
Phase 3
1,361
(intention-to-treat)
(rwwyucrawa) = lqrbdmqffi rdbeoexooz (bxjrewkyyu )
Positive
06 May 2020
(per-protocol)
(rwwyucrawa) = hzybvwwdev rdbeoexooz (bxjrewkyyu )
Phase 2/3
17
(wsbfllzhpf) = ftpdszfvnd cfmxlsbfip (krgpgnisff )
-
05 May 2020
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