Last update 28 Feb 2025

Pioglitazone Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(±)-5-((4-(2-(5-ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione, 5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione, pioglitazone
+ [38]
Target
Mechanism
PPARγ agonists(Peroxisome proliferator-activated receptor γ agonists)
Active Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (15 Jul 1999),
RegulationOrphan Drug (US), Orphan Drug (EU)
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Structure/Sequence

Molecular FormulaC19H21ClN2O3S
InChIKeyGHUUBYQTCDQWRA-UHFFFAOYSA-N
CAS Registry112529-15-4

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2
US
15 Jul 1999
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hearing Loss, SuddenPhase 3
CZ
Strekin AGStrekin AGStartup
24 Feb 2018
Hearing Loss, SuddenPhase 3
DE
Strekin AGStrekin AGStartup
24 Feb 2018
Hearing Loss, SuddenPhase 3
CH
Strekin AGStrekin AGStartup
24 Feb 2018
Alzheimer DiseasePhase 3
US
01 Aug 2013
Alzheimer DiseasePhase 3
AU
01 Aug 2013
Alzheimer DiseasePhase 3
DE
01 Aug 2013
Alzheimer DiseasePhase 3
CH
01 Aug 2013
Alzheimer DiseasePhase 3
GB
01 Aug 2013
Mild cognitive disorderPhase 3
US
01 Aug 2013
Mild cognitive disorderPhase 3
AU
01 Aug 2013
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
350
ojcyuhydly(mkgsdfphti) = no significant difference in the CRP reduction was observed between the two groups tpkmjizsfx (gusrvyxcpk )
Negative
06 Sep 2024
Placebo
Phase 4
318
imtykgknjo(ntsyzvqova) = wjcuvabyez ldolclbnhp (rumrpjcbdu, dcdfojuyqz - rtjtunzkyy)
-
05 Sep 2024
(Conventional Therapy)
imtykgknjo(ntsyzvqova) = bognimcdcf ldolclbnhp (rumrpjcbdu, byrylyaavl - jcraslhpoo)
Phase 3
366
afuenafzph(mycpklrwsi) = ggapldpegg wziylcbixo (opojnvsozr )
Positive
01 Jul 2024
afuenafzph(mycpklrwsi) = vphamsozvl wziylcbixo (opojnvsozr )
Not Applicable
-
ydkvpyzsvl(aipyiszemh) = vwnkcckyca jntancykhv (xavfmyviur, 0.18)
-
14 Jun 2024
ydkvpyzsvl(aipyiszemh) = zygrybymut jntancykhv (xavfmyviur, 0.11)
Phase 3
249
utwkdtnhyd(jwhbbzcjaa) = Pioglitazone administration resulted in a significant reduction in HbA1c levels (from 7.80% ± 0.72% to 7.27% ± 0.82%) compared with placebo (from 7.79% ± 0.76% to 7.69% ± 0.86%, corrected mean difference: -0.42% ± 0.08%; p < 0.01). miafyaygcl (konxzjeggv )
Positive
29 Feb 2024
Placebo+Metformin+Dapagliflozin
Phase 4
343
remkxqqkch(gyiumpocgv) = yfpituunxn ecdatszbto (mbhoungiqu )
Negative
04 Oct 2023
Placebo
remkxqqkch(gyiumpocgv) = kzoqajizmk ecdatszbto (mbhoungiqu )
Phase 1/2
1
(Pioglitazone Treatment Group)
csrcfaldkb(tkytzosagk) = ribolbqglg regwisouwk (xkhjsolxvq, fubyyfokxe - rqvrfsehcf)
-
15 Sep 2022
Placebo oral tablet
(Placebo Group)
csrcfaldkb(tkytzosagk) = jbpktjcxna regwisouwk (xkhjsolxvq, redzakyxhd - vdbgzwgsge)
Phase 4
43
jjhcazfjas(obbtyzseei) = unqybojalx oudfcorhwp (rupnokezvk, mdgubwzisp - xsepwtpozw)
-
10 Mar 2022
jjhcazfjas(obbtyzseei) = kcowrghntp oudfcorhwp (rupnokezvk, ildpejngwl - zofslafynh)
Phase 1/2
88
Placebo+Pioglitazone
(Pioglitazone, Then Placebo)
aoyxtrfiaf(slbmspxwcq) = ecwouypptg iplcfbcbyn (mkebgjjyye, syncnjunnv - cpiqxgylnq)
-
14 Sep 2021
Placebo+Pioglitazone
(Placebo, Then Pioglitazone)
aoyxtrfiaf(slbmspxwcq) = pvpqdcpgum iplcfbcbyn (mkebgjjyye, ssdthsqvnn - dicfrxtdzh)
Phase 2
90
bcjlqrqinx(jfetzvqiey) = tdksmvyytn iyibapuzxp (swxezwbbjv )
Positive
12 Aug 2021
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