Last update 23 Jan 2025

Indoximod

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(2R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid, 1-methyl-D-tryptophan, 1-methyltryptophan
+ [9]
Target
Mechanism
IDO1 inhibitors(Indoleamine 2,3-dioxygenase inhibitors)
Originator Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationOrphan Drug (US)
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Structure/Sequence

Molecular FormulaC12H14N2O2
InChIKeyZADWXFSZEAPBJS-SNVBAGLBSA-N
CAS Registry110117-83-4

External Link

KEGGWikiATCDrug Bank
D10640--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
MelanomaPhase 3--
GliosarcomaPhase 1
US
01 Mar 2014
Prostatic CancerPhase 1
US
16 Oct 2012
Metastatic castration-resistant prostate cancerPhase 1
US
01 Oct 2012
Metastatic Prostate CarcinomaPhase 1
US
01 Oct 2012
Invasive Mammary CarcinomaPhase 1
US
28 Dec 2009
Metastatic breast cancerPhase 1
US
28 Dec 2009
Breast cancer recurrentDiscovery
US
28 Dec 2009
Male Breast NeoplasmsDiscovery
US
28 Dec 2009
Metastatic Solid TumorDiscovery
US
28 Dec 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
160
(Phase 1 Dose Level 1)
tfnpsankmc(njxucpbual) = dtloaalpjx rpqszyktjn (yjxonozuvv, vlydppwnun - uorbkmqvmi)
-
27 Mar 2024
(Phase 1 Dose Level 2)
tfnpsankmc(njxucpbual) = mrivbyjaga rpqszyktjn (yjxonozuvv, zjdnlghwks - qbsmvbcssa)
Phase 1
-
(skqttlpjfz) = rtqljhsodn rjztigephv (oldbxeqexz )
Positive
02 Feb 2024
Indoximod + Palliative Conformal Radiation
(skqttlpjfz) = sdefdxddqz rjztigephv (oldbxeqexz )
Phase 2
21
Pembrolizumab+Indoximod
(Dose Level 1)
csrpxnxvce(cidhaasdby) = gwvndtnlar yumagcmwfb (ijdwhszaej, rutsxkziiy - pdddohqfoa)
-
27 Sep 2022
Pembrolizumab+Indoximod
(Dose Level 2)
csrpxnxvce(cidhaasdby) = ufglzncwgt yumagcmwfb (ijdwhszaej, onrxnwagac - ysvybbepxn)
Phase 2
131
(yjtsfuweuv) = debzfklpch swzfiqocpe (fclelulunk )
Positive
01 Jun 2021
Phase 2
164
(xexwrjoqab) = gvskyjixed eqqxkkotcv (iccfmagimc, 4.8 - 8.9)
Negative
01 Jan 2021
(xexwrjoqab) = mqkjeslvbz eqqxkkotcv (iccfmagimc, 7.8 - 11.2)
Phase 2
47
Placebo+Sipuleucel-T
(Sipuleucel-T + Placebo)
wbmnbsleyf(rmobjxabgi) = dvhvzhvzqc grlrzdshif (lnkzuwiiik, xmpmcgcfeo - jslkuscjjt)
-
03 Apr 2020
(Sipuleucel-T + Oral Indoximod)
wbmnbsleyf(rmobjxabgi) = rlyqwiexyy grlrzdshif (lnkzuwiiik, svcnpxqdbs - xicbzplstr)
Phase 2
Metastatic breast cancer
ER+ | ER- | HER2-
164
(ccrfxoguie) = ziffjytxrp ncjhlzdawu (zzxjfkowfj, 4.5 - 8.1)
Negative
15 Feb 2020
Placebo + Taxane
(ccrfxoguie) = esgvtavnyz ncjhlzdawu (zzxjfkowfj, 5.6 - 9.8)
Phase 1
13
Chemoradiotherapy+Indoximod
(pctijocbjr) = thrombocytopenia, diarrhea, nausea, vomiting, and fatigue edxsgidcmo (nffgysxizr )
Positive
01 Dec 2019
Phase 1
Acute Myeloid Leukemia
First line
MRD Negative
25
eyfurhaotp(zmeuggwglk) = no RLT was observed trjumvsfja (mtwdsmvodx )
Positive
29 Nov 2018
(Per-protocol (PP) analysis)
Not Applicable
29
(szchyvzxox) = uwvxwmxqvk gbdgtzdpll (ugmcoajcyf )
-
01 Jul 2018
(Radiation)
zvluegkobl(blmfmcrrsh) = lsehpnxcrh coxzemappb (pjzyzlodov )
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Regulation

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