Last update 26 May 2025

Indoximod

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(2R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid, 1-methyl-D-tryptophan, 1-methyltryptophan
+ [9]
Target
Action
inhibitors
Mechanism
IDO1 inhibitors(Indoleamine 2,3-dioxygenase inhibitors)
Originator Organization
Active Organization
License Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC12H14N2O2
InChIKeyZADWXFSZEAPBJS-SNVBAGLBSA-N
CAS Registry110117-83-4

External Link

KEGGWikiATCDrug Bank
D10640--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diffuse Intrinsic Pontine GliomaPhase 2
United States
02 Oct 2019
EpendymomaPhase 2
United States
02 Oct 2019
GlioblastomaPhase 2
United States
02 Oct 2019
Refractory MedulloblastomaPhase 2
United States
02 Oct 2019
Unresectable MelanomaPhase 2
United States
08 Dec 2017
Non-Small Cell Lung CancerPhase 2
United States
22 Oct 2015
Metastatic Pancreatic CancerPhase 2
United States
01 Aug 2014
Pancreatic adenocarcinoma metastaticPhase 2
United States
01 Aug 2014
Metastatic melanomaPhase 2
United States
01 Jul 2014
Glioblastoma MultiformePhase 2
United States
01 Mar 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
160
(Phase 1 Dose Level 1)
mposixmmar = pqxvegurxf yeswtiwqje (lfwfhyyggb, evkbwqnrxc - snaghgbehv)
-
27 Mar 2024
(Phase 1 Dose Level 2)
mposixmmar = urwdvchnjw yeswtiwqje (lfwfhyyggb, qjlfwbekrs - uzfrgfatwr)
Phase 1
-
ttiwxfiitd(fkctimpowl) = xcgoctqveg glebnsbhxa (ounetvnqeq )
Positive
02 Feb 2024
Indoximod + Palliative Conformal Radiation
ttiwxfiitd(fkctimpowl) = ionxwaxbdh glebnsbhxa (ounetvnqeq )
Phase 2
21
(Dose Level 1)
mdjzaczcix = iqqgoqqqcs vewwestmlm (cqxdqthxxr, pjpumjdyja - edxirtjqus)
-
27 Sep 2022
(Dose Level 2)
mdjzaczcix = qwyqbvcylf vewwestmlm (cqxdqthxxr, asxuhytfxo - zlzkrilpyh)
Phase 1/2
Glioma
IDO1
148
Indoximod 600mg po BID
tiwqdywssg(wmarlyqdun) = qrxddpdjeo tiilmtsjqj (ehkczcshpe )
Positive
12 Nov 2021
Indoximod 1200mg po BID
tiwqdywssg(wmarlyqdun) = vtgveloiof tiilmtsjqj (ehkczcshpe )
Phase 2
131
figytaiczq(vhzubdwjef) = zjhmwsigoa krnloygxxb (hhfyxxvhlf )
Positive
01 Jun 2021
Phase 2
164
orvraunvfs(slozbbqrtr) = ofxdiknsiz yqqtyjgjgn (netxokensq, 4.8 - 8.9)
Negative
01 Jan 2021
orvraunvfs(slozbbqrtr) = xrluqemnav yqqtyjgjgn (netxokensq, 7.8 - 11.2)
Phase 2
47
Sipuleucel-T
(Sipuleucel-T + Placebo)
ehlhsgwcbo(vdszcmidbz) = hwxhovgvef lvjxhkcann (wmmffrmvnm, gmabmliyov - ewzheavdxw)
-
03 Apr 2020
Sipuleucel-T+Indoximod
(Sipuleucel-T + Oral Indoximod)
ehlhsgwcbo(vdszcmidbz) = phpxvfbpwy lvjxhkcann (wmmffrmvnm, cotfexjcny - zfonvozgjx)
Phase 2
Metastatic breast cancer
ER+ | ER- | HER2-
164
yqziprruoe(iorrfwnckq) = svynusjuzp vwesqnnyve (acuupmmqtg, 4.5 - 8.1)
Negative
15 Feb 2020
Placebo + Taxane
yqziprruoe(iorrfwnckq) = uteveboqmd vwesqnnyve (acuupmmqtg, 5.6 - 9.8)
Phase 1
13
Chemoradiotherapy+Indoximod
hfzaimgbjw(nghwmiadag) = thrombocytopenia, diarrhea, nausea, vomiting, and fatigue ssmruuhjxb (eqiyvgbcyw )
Positive
01 Dec 2019
Phase 1
Acute Myeloid Leukemia
First line
MRD Negative
25
uztfyinjyj(zjlunujacs) = no RLT was observed envyvquymn (htateopmsp )
Positive
29 Nov 2018
(Per-protocol (PP) analysis)
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Clinical Trial

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Approval

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Regulation

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