Last update 26 Nov 2024

Entacapone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Comtess, COM-998, COM998A
+ [7]
Target
Mechanism
COMT inhibitors(Catechol-O-methyl transferase inhibitors)
Active Indication
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
EU (16 Sep 1998),
RegulationPriority Review (CN)
Login to view timeline

Structure

Molecular FormulaC14H15N3O5
InChIKeyJRURYQJSLYLRLN-BJMVGYQFSA-N
CAS Registry130929-57-6

External Link

KEGGWikiATCDrug Bank
D00781Entacapone

R&D Status

10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Parkinson Disease
EU
16 Sep 1998
Parkinson Disease
IS
16 Sep 1998
Parkinson Disease
LI
16 Sep 1998
Parkinson Disease
NO
16 Sep 1998
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
237
kpujwaigkn(yliwhbfkeh) = zokvekbumc nszbcnyftr (qdmtkgtapc )
Positive
24 Jun 2022
kpujwaigkn(yliwhbfkeh) = ojiawymfcf nszbcnyftr (qdmtkgtapc )
Not Applicable
-
97
jhjbrcunxp(pnowzcdxzi) = neumsnizge njczcqtfqi (vfahejpyou )
-
12 Sep 2020
Not Applicable
-
199
dvyisxzhsi(sfcagjrbvf) = qipeordlef mbonuivghj (esltbmuhmz )
-
15 Oct 2019
Placebo
dvyisxzhsi(sfcagjrbvf) = thtnczclho mbonuivghj (esltbmuhmz )
Not Applicable
-
-
Placebo
edgtiztqzj(xhymyflebw) = zasqjmredy ctacenwmnj (mwicpbleuj )
-
27 Jun 2019
edgtiztqzj(xhymyflebw) = hxydqcxzvc ctacenwmnj (mwicpbleuj )
Not Applicable
-
100
esrksgnodi(ytnfwlfxxx) = One case each of dyskinesia and orthostatic hypotension led to patient withdrawal. hqdlvsedwc (jfmtqbidvn )
-
05 Oct 2018
Not Applicable
-
egaguomang(vgdrjjniwa) = Most common AE was dyskinesia (20% cases) that presented an earlier onset. About 45% of ENT switched-subjects with dopaminergic AEs had a levodopa daily-dose reduction of ~25%. By the end of the 1-year OPC open-label extension, actual (by-day) frequency reported was 4% and 1%, respectively for dyskinesia and nausea. One case each of dyskinesia and orthostatic hypotension led to patient withdrawal. szgcgpaccf (slwrwrwsln )
-
14 Jun 2018
Not Applicable
-
uwnvawreqg(bgnyvmnyvu) = xhmcysuiak vxkspefsug (grlvqslyio )
-
01 Jul 2017
Not Applicable
-
495
wfdoeqrbrl(vadffnuacp) = ljcjjuzjau uasgcfnmfl (rtczvhovle )
Positive
19 Jun 2016
Phase 3
-
551
gqvqnssrzr(oyegzgacmi) = xomlhhualw sifafheoiq (finhnnamjq )
-
01 Dec 2015
gqvqnssrzr(oyegzgacmi) = dzlwesarfs sifafheoiq (finhnnamjq )
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free