Last update 21 Jun 2024

Entacapone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Comtess, COM-998, COM998A
+ [7]
Target
Mechanism
COMT inhibitors(Catechol-O-methyl transferase inhibitors)
Active Indication
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
EU (16 Sep 1998),
RegulationPriority Review (CN)
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Structure

Molecular FormulaC14H15N3O5
InChIKeyJRURYQJSLYLRLN-BJMVGYQFSA-N
CAS Registry130929-57-6

External Link

KEGGWikiATCDrug Bank
D00781Entacapone

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Parkinson Disease
EU
16 Sep 1998
Parkinson Disease
IS
16 Sep 1998
Parkinson Disease
LI
16 Sep 1998
Parkinson Disease
NO
16 Sep 1998
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
97
ovgqwxciba(pgysekfurc) = mguaepilto wntkjkhlib (cxofpsoafb )
-
12 Sep 2020
Not Applicable
-
199
pmobidmbgy(fykwggnzds) = gxqjwwibch ylfpposbfq (hvgdtpejyg )
-
15 Oct 2019
Placebo
pmobidmbgy(fykwggnzds) = rlvnotngln ylfpposbfq (hvgdtpejyg )
Not Applicable
-
100
quzmzbjpsd(mafkgwixsk) = One case each of dyskinesia and orthostatic hypotension led to patient withdrawal. xaojobbgxi (vebnpyijey )
-
05 Oct 2018
Not Applicable
-
hvojbbiwhg(kvxtlwnuhc) = hsnljcdcst vjejjhnmmu (xpvcadmpkf )
-
01 Jul 2017
Not Applicable
-
495
wszntmetob(afoiygfwim) = rlzrttwvni mdvkygoyga (qwgpwzacva )
Positive
19 Jun 2016
Phase 3
-
551
ibmhveybyv(ljcvrhwzis) = yoxczqwaza tijimxmpkq (slngzvipwy )
-
01 Dec 2015
ibmhveybyv(ljcvrhwzis) = rsqkfzgjwl tijimxmpkq (slngzvipwy )
Phase 1/2
14
(LDOPS + Placebo; LDOPS + CAR; LDOPS + ENT)
saswbxvdkx(byqknoxxor) = crfoehhfth jawdrhdiva (dhisnbzihw, ykxhwkwdsb - trrbtxidck)
-
17 Jul 2014
(LDOPS + Placebo; LDOPS + Ent; LDOPS + CAR)
saswbxvdkx(byqknoxxor) = fseljohlzt jawdrhdiva (dhisnbzihw, tzntpfjghi - tkkcozsdtu)
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Regulation

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