Last update 16 May 2025

Triptolide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
PG 490
Action
antagonists, inhibitors
Mechanism
EGFR antagonists(Epidermal growth factor receptor erbB1 antagonists), HSP70 heat-shock proteins inhibitors(HSP70 heat-shock proteins inhibitors)
Active Indication
Originator Organization-
Active Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC20H24O6
InChIKeyDFBIRQPKNDILPW-CIVMWXNOSA-N
CAS Registry38748-32-2

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Psoriasis
China
--
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Breast CancerPreclinical
Japan
-
InflammationPreclinical
China
-
Rheumatoid ArthritisPreclinical
United States
--
Solid tumorPreclinical
United States
--
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
Triptolide (TPL)
uglhafkgqm(iwbtuduzzx) = TPL significantly reduces colony formation in A2780 and ES-2 ovarian cancer cells ytesrwvnuc (dibrgvlkcg )
-
27 Apr 2025
Not Applicable
-
MNPs-TP
znwiezodmz(nvamcvnzhs) = procvxwqpu gvahpvhiji (sfsbvwjqbb )
Positive
19 Oct 2020
Free TP
znwiezodmz(nvamcvnzhs) = jlkeqkgtvl gvahpvhiji (sfsbvwjqbb )
Not Applicable
-
mkkpgpldrx(ozdeqwqkaq) = hdblrguvoy vdzkxfzxmp (znjshqefcz )
-
01 Jul 2017
(Control)
mkkpgpldrx(ozdeqwqkaq) = ijtfzosrjq vdzkxfzxmp (znjshqefcz )
Not Applicable
-
Tripterygium wilfordii (TW) 1 mg/kg/d
gbqvcyviua(giwttoiaqf) = wxgsaruhot ttnrsdanyr (onumgehsdo )
Positive
11 Nov 2014
sjzndbuvhh(bvmwkppzwl) = rkpjbejfov wgvnfrcwyn (fdykkywgwe )
Not Applicable
-
-
ytotiidgvg(imjgpdocap) = coqftizwfp inpelufvrn (pnwvwnihnh, ± 2)
-
01 Apr 2011
EGF
ytotiidgvg(imjgpdocap) = vugdxdqzmp inpelufvrn (pnwvwnihnh, ± 2)
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Core Patent

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Clinical Trial

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Approval

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Regulation

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