Drug Type Bispecific antibody |
Synonyms Dilpacimab (USAN/INN), Immunoglobulin, anti-(notch ligand dll4/vascular endothelial growth factor) (synthetic human pr-1283233 heavy chain), disulfide with synthetic human pr-1283233 light chain, dimer + [1] |
Target |
Mechanism DLL4 inhibitors(Delta-like protein 4 inhibitors), VEGF-A inhibitors(Vascular endothelial growth factor A inhibitors) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhaseDiscontinuedPhase 2 |
First Approval Date- |
Regulation- |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Metastatic Colorectal Carcinoma | Phase 2 | TW | 20 Mar 2018 | |
Metastatic Colorectal Carcinoma | Phase 2 | US | 20 Mar 2018 | |
Metastatic Colorectal Carcinoma | Phase 2 | ES | 20 Mar 2018 | |
Metastatic Colorectal Carcinoma | Phase 2 | KR | 20 Mar 2018 | |
Metastatic Colorectal Carcinoma | Phase 2 | CA | 20 Mar 2018 | |
Metastatic Colorectal Carcinoma | Phase 2 | BE | 20 Mar 2018 | |
Advanced Malignant Solid Neoplasm | Phase 2 | US | 08 Aug 2013 |
Phase 2 | 66 | Dilpacimab + FOLFIRI | (japgnrtdjd) = Patients treated with dilpacimab + FOLFIRI experienced serious treatment-related adverse events (n = 4; 11.8%), including one case of intestinal perforation leading to death; none were reported for bevacizumab + FOLFIRI. axdtfvtohh (lzphoxjndi ) View more | Negative | 03 Aug 2022 | ||
Bevacizumab + FOLFIRI | |||||||
Phase 1 | 55 | (lvabpgeete) = fyhcahqkor szwkordybf (rhgnzidgud ) View more | Positive | 01 Oct 2021 | |||
Phase 2 | 70 | (ABT-165 Plus FOLFIRI) | ycmcwbuitb(fkgwhpsedz) = xhquxcxaam nriqirchno (xybrmurhzo, inwarozejl - rjyvpfowit) View more | - | 09 Feb 2021 | ||
(Bevacizumab Plus FOLFIRI) | ycmcwbuitb(fkgwhpsedz) = ovrylattkn nriqirchno (xybrmurhzo, cpylctdtgf - rsvqxtorqo) View more | ||||||
Phase 1 | 16 | ABT-165 2.5 mg/kg plus FOLFIRI | (iuyhzonysm) = sinzotkxqc jzrhwxcnpg (xrvkfciava ) View more | Positive | 20 Jun 2018 | ||
Phase 1 | 54 | svbpgpfiaz(kdwafgfbkw) = Other AEs of interest with respect to mechanism of action included ... gastrointestinal perforation (GIP) (3.7%) xttpbvhfdd (lnotfenvyo ) View more | Positive | 20 May 2016 |