Delving into the Latest Updates on Mitsubishi Tanabe Pharma Factory Ltd. with Synapse

Overview

Basic Info

Introduction

Mitsubishi Tanabe Pharma Factory Ltd. is a Japanese corporation that operates as part of Mitsubishi Chemical Group Corp. and is headquartered in Osaka. The company specializes in the production and distribution of pharmaceutical products.

Tags

Other Diseases

Infectious Diseases

Respiratory Diseases

Small molecule drug

Biological products

Toxoid vaccine

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Infectious Diseases	7
Nervous System Diseases	3
Endocrinology and Metabolic Disease	3
Immune System Diseases	2

Top 5 Drug Type	Count

Small molecule drug	12
Inactivated vaccine	1
Toxoid vaccine	1
Prophylactic vaccine	1
Biological products	1

Top 5 Target	Count

H1 receptor(Histamine H1 receptor)	2
D2 receptor(Dopamine D2 receptor)	2
Tetanus toxin	1
GR(Glucocorticoid receptor)	1
hemagglutinin(Influenza virus hemagglutinin glycoproteins)	1

AbstractHelicobacter pylori (Hp) infection is related to the pathogenesis of chronic gastric disorders and extragastric diseases. Here, we examined the anorexigenic and anxiogenic effects of Hp vacuolating cytotoxin A (VacA) through activation of hypothalamic urocortin1 (Ucn1). VacA was detected in the hypothalamus after peripheral administration and increased Ucn1 mRNA expression and c-Fos-positive cells in the hypothalamus but not in the nucleus tractus solitarius. c-Fos and Ucn1-double positive cells were detected. CRF1 and CRF2 receptor antagonists suppressed VacA-induced anxiety and anorexia, respectively. VacA activated single paraventricular nucleus neurons and A7r5 cells; this activation was inhibited by phospholipase C (PLC) and protein kinase C (PKC) inhibitors. VacA causes anorexia and anxiety through the intracellular PLC-PKC pathway, migrates across the blood-brain barrier, and activates the Ucn1-CRF receptor axis.

100 Deals associated with Mitsubishi Tanabe Pharma Factory Ltd.

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100 Translational Medicine associated with Mitsubishi Tanabe Pharma Factory Ltd.

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Pipeline

Pipeline Snapshot as of 26 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Approved

15

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Colestilan ( Phosphates )	Hypercholesterolemia More	Approved
Oxiconazole Nitrate ( fungal CYP51A1 )	Dermatomycoses More	Approved
Promethazine Hydrochloride ( H1 receptor )	Anesthesia More	Approved
Influenza vaccine quadrivalent(Research Fdn for Microbial Diseases of Osaka University) ( hemagglutinin )	Influenza, Human More	Approved
Fluocinonide ( GR )	Alopecia Areata More	Approved