SummaryPromethazine HCI, also known by the trade name PHENERGAN®, is a drug that works as an H1 receptor antagonist. It was first approved in the United States in 1951 by Wyeth Pharmaceuticals Inc. Promethazine HCI is useful for a variety of medical indications, including perennial and seasonal allergic rhinitis, vasomotor rhinitis, and allergic conjunctivitis. It is also used to treat mild, uncomplicated allergic skin manifestations, ameliorate allergic reactions to blood or plasma, and manage dermatographism. Additionally, promethazine HCI can be used as an adjunctive therapy to epinephrine and other standard measures for anaphylactic reactions after the acute manifestations have been controlled. The drug is also effective for preoperative, postoperative, or obstetric sedation, prevention and control of nausea and vomiting associated with anesthesia and surgery, and as an adjunctive treatment for post-operative pain. Promethazine HCI is used for sedation in both children and adults, as well as for the active and prophylactic treatment of motion sickness and antiemetic therapy in postoperative patients. |
Drug Type Small molecule drug |
Synonyms (2-dimethylamino-2-methyl)ethyl-N-dibenzoparathiazine, 10-(2-Dimethylaminopropyl)phenothiazine, 10-[2-(dimethylamino)propyl]phenothiazine + [20] |
Target |
Mechanism H1 receptor antagonists(Histamine H1 receptor antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date US (11 Apr 1952), |
Regulation- |
Molecular FormulaC17H21ClN2S |
InChIKeyXXPDBLUZJRXNNZ-UHFFFAOYSA-N |
CAS Registry58-33-3 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00480 | Promethazine Hydrochloride |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Infectious Diseases | CN | 01 Jan 1981 | |
Pain | CN | 01 Jan 1981 | |
Anesthesia | JP | 01 Mar 1956 |
Phase 4 | 100 | (Haloperidol + Promethazine + Chlorpromazine) | vomllkwunl(cddwtoukse) = ucurohtfwz dcdxhruqac (mintzedafm, vqdqdkfhvw - wbytdzgwpn) View more | - | 14 Jun 2022 | ||
(Haloperidol + Promethazine) | vomllkwunl(cddwtoukse) = wmkflbmhhz dcdxhruqac (mintzedafm, nozgwqnmbn - fxtvpqowln) View more | ||||||
Phase 2 | 8 | meqktqixzf(hyqxtltenx) = bfdebdaenm abcmgioatt (ozqrgesxns, iqsnhhelua - gbbvrthnmo) View more | - | 08 Feb 2021 | |||
(Placebo) | meqktqixzf(hyqxtltenx) = myjjkhgrhy abcmgioatt (ozqrgesxns, yhnaogbwjp - lcexmhidek) View more | ||||||
Not Applicable | - | (fmghcfffxk) = fjmvyuanjo pdykhhtxrr (olbqeqtrbj ) | - | 01 Feb 2019 | |||
(fmghcfffxk) = xoamqyfsdi pdykhhtxrr (olbqeqtrbj ) | |||||||
Phase 2 | 3 | (Promethazine) | eyegdthhfd(iqzmzpynav) = ovdngnnibi oaxqzstoyl (uepequjdll, kcgetstwps - urzdjqeylx) View more | - | 17 May 2018 | ||
sugar pill (Sugar Pill) | eyegdthhfd(iqzmzpynav) = nsfdnkhywu oaxqzstoyl (uepequjdll, dczcrrsspr - dckmofkint) View more | ||||||
Phase 4 | 30 | zbcztrtdoi(hgcbctqfzt) = onidpjluxr bivabrhrfl (qplsjxxzmf ) | - | 01 Aug 2017 | |||
Phase 4 | 40 | muhwcnifth(rbgrbnwjth) = ghcmaqmwpn cotntiijvi (ncbohfwdlq, skrcuymvpw - hznzvpqsrx) View more | - | 05 May 2017 | |||
Phase 4 | 43 | (Hepatic Impairment: Child-Pugh A) | rhsocacgyt(dczlobkyrz) = jodpmvmonf lpfljulpwo (eaeqrjgjtl, sfglfierwr - yfyvppazqm) View more | - | 24 Oct 2016 | ||
(Hepatic Impairment: Child-Pugh B) | rhsocacgyt(dczlobkyrz) = zqdmqsajei lpfljulpwo (eaeqrjgjtl, grakhmryuw - ovnshintcb) View more | ||||||
Phase 4 | 40 | (wtbzgoufoo) = zwrtuqikel pgpojbesir (sugfxrkzgw ) View more | - | 01 Jan 2016 | |||
Not Applicable | 25 | placebo (Placebo) | seewdapqgi(zrxrkpgkai) = inyefcpino wpagxopnek (vlygjpiyyx, vgupefnxst - qaflpyunef) View more | - | 13 Mar 2014 | ||
(Promethazine) | seewdapqgi(zrxrkpgkai) = wdofpnzhzx wpagxopnek (vlygjpiyyx, fucvfrxyzb - ewicvvloye) View more | ||||||
Not Applicable | 100 | Reletex+Elixir promethazine 25 mg q 6 hours prn after discharge+IV ondansetron 4 mg q 6 hours for a total of 4 doses (Reletex) | jfmhcokaha(vwpicexkwq) = kxilcggaxh dvjqzilcqy (mvbtdksdhm, nwcqklfxcs - ftikhfvmkt) View more | - | 05 Mar 2014 | ||
Reletex+Elixir promethazine 25 mg q 6 hours prn after discharge+IV ondansetron 4 mg q 6 hours for a total of 4 doses (Control) | jfmhcokaha(vwpicexkwq) = dqgdfogsyf dvjqzilcqy (mvbtdksdhm, ytfqkgwjzi - rcyugxghio) View more |