Last update 21 Nov 2024

Promethazine Hydrochloride

Overview

Basic Info

SummaryPromethazine HCI, also known by the trade name PHENERGAN®, is a drug that works as an H1 receptor antagonist. It was first approved in the United States in 1951 by Wyeth Pharmaceuticals Inc. Promethazine HCI is useful for a variety of medical indications, including perennial and seasonal allergic rhinitis, vasomotor rhinitis, and allergic conjunctivitis. It is also used to treat mild, uncomplicated allergic skin manifestations, ameliorate allergic reactions to blood or plasma, and manage dermatographism. Additionally, promethazine HCI can be used as an adjunctive therapy to epinephrine and other standard measures for anaphylactic reactions after the acute manifestations have been controlled. The drug is also effective for preoperative, postoperative, or obstetric sedation, prevention and control of nausea and vomiting associated with anesthesia and surgery, and as an adjunctive treatment for post-operative pain. Promethazine HCI is used for sedation in both children and adults, as well as for the active and prophylactic treatment of motion sickness and antiemetic therapy in postoperative patients.
Drug Type
Small molecule drug
Synonyms
(2-dimethylamino-2-methyl)ethyl-N-dibenzoparathiazine, 10-(2-Dimethylaminopropyl)phenothiazine, 10-[2-(dimethylamino)propyl]phenothiazine
+ [20]
Mechanism
H1 receptor antagonists(Histamine H1 receptor antagonists)
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Structure

Molecular FormulaC17H21ClN2S
InChIKeyXXPDBLUZJRXNNZ-UHFFFAOYSA-N
CAS Registry58-33-3
View All Structures (2)

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Infectious Diseases
CN
01 Jan 1981
Pain
CN
01 Jan 1981
Anesthesia
JP
01 Mar 1956
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
100
(Haloperidol + Promethazine + Chlorpromazine)
vomllkwunl(cddwtoukse) = ucurohtfwz dcdxhruqac (mintzedafm, vqdqdkfhvw - wbytdzgwpn)
-
14 Jun 2022
(Haloperidol + Promethazine)
vomllkwunl(cddwtoukse) = wmkflbmhhz dcdxhruqac (mintzedafm, nozgwqnmbn - fxtvpqowln)
Phase 2
8
meqktqixzf(hyqxtltenx) = bfdebdaenm abcmgioatt (ozqrgesxns, iqsnhhelua - gbbvrthnmo)
-
08 Feb 2021
meqktqixzf(hyqxtltenx) = myjjkhgrhy abcmgioatt (ozqrgesxns, yhnaogbwjp - lcexmhidek)
Not Applicable
-
(fmghcfffxk) = fjmvyuanjo pdykhhtxrr (olbqeqtrbj )
-
01 Feb 2019
(fmghcfffxk) = xoamqyfsdi pdykhhtxrr (olbqeqtrbj )
Phase 2
3
(Promethazine)
eyegdthhfd(iqzmzpynav) = ovdngnnibi oaxqzstoyl (uepequjdll, kcgetstwps - urzdjqeylx)
-
17 May 2018
sugar pill
(Sugar Pill)
eyegdthhfd(iqzmzpynav) = nsfdnkhywu oaxqzstoyl (uepequjdll, dczcrrsspr - dckmofkint)
Phase 4
30
zbcztrtdoi(hgcbctqfzt) = onidpjluxr bivabrhrfl (qplsjxxzmf )
-
01 Aug 2017
Phase 4
40
muhwcnifth(rbgrbnwjth) = ghcmaqmwpn cotntiijvi (ncbohfwdlq, skrcuymvpw - hznzvpqsrx)
-
05 May 2017
Phase 4
43
(Hepatic Impairment: Child-Pugh A)
rhsocacgyt(dczlobkyrz) = jodpmvmonf lpfljulpwo (eaeqrjgjtl, sfglfierwr - yfyvppazqm)
-
24 Oct 2016
(Hepatic Impairment: Child-Pugh B)
rhsocacgyt(dczlobkyrz) = zqdmqsajei lpfljulpwo (eaeqrjgjtl, grakhmryuw - ovnshintcb)
Phase 4
40
(wtbzgoufoo) = zwrtuqikel pgpojbesir (sugfxrkzgw )
-
01 Jan 2016
Not Applicable
25
placebo
(Placebo)
seewdapqgi(zrxrkpgkai) = inyefcpino wpagxopnek (vlygjpiyyx, vgupefnxst - qaflpyunef)
-
13 Mar 2014
(Promethazine)
seewdapqgi(zrxrkpgkai) = wdofpnzhzx wpagxopnek (vlygjpiyyx, fucvfrxyzb - ewicvvloye)
Not Applicable
100
Reletex+Elixir promethazine 25 mg q 6 hours prn after discharge+IV ondansetron 4 mg q 6 hours for a total of 4 doses
(Reletex)
jfmhcokaha(vwpicexkwq) = kxilcggaxh dvjqzilcqy (mvbtdksdhm, nwcqklfxcs - ftikhfvmkt)
-
05 Mar 2014
Reletex+Elixir promethazine 25 mg q 6 hours prn after discharge+IV ondansetron 4 mg q 6 hours for a total of 4 doses
(Control)
jfmhcokaha(vwpicexkwq) = dqgdfogsyf dvjqzilcqy (mvbtdksdhm, ytfqkgwjzi - rcyugxghio)
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