| Disease Domain | Count |
|---|---|
| Nervous System Diseases | 3 |
| Infectious Diseases | 2 |
| Immune System Diseases | 1 |
| Top 5 Drug Type | Count |
|---|---|
| Small molecule drug | 4 |
Target |
Mechanism CGRP receptor antagonists |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. United States |
First Approval Date09 Mar 2023 |
Mechanism 5-HT2A receptor antagonists [+1] |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. United States |
First Approval Date13 Aug 2009 |
Target |
Mechanism nAChRα4&β2 agonists |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. United States |
First Approval Date10 May 2006 |
Start Date27 Oct 2025 |
Sponsor / Collaborator [+3] |
Start Date18 Mar 2025 |
Sponsor / Collaborator |
Start Date30 Sep 2024 |
Sponsor / Collaborator |



| Drug(Targets) | Indications | Global Highest Phase |
|---|---|---|
Varenicline Tartrate ( nAChRα4&β2 ) | Xerophthalmia More | NDA/BLA |
Adrenaline ( adrenergic receptor ) | Anaphylaxis More | NDA/BLA |
Zavegepant ( CGRP receptor ) | Acute migraine More | NDA/BLA |
Asenapine Maleate ( 5-HT2A receptor x D2 receptor ) | Schizophrenia More | Clinical |
Buprenorphine Hydrochloride ( κ opioid receptor x μ opioid receptor ) | Chronic Pain More | Pending |





