Shanghai Bozhiyanxin Pharmaceutical Co., Ltd.

Primary Objective: To observe the pharmacokinetic process of BCM476 capsules in healthy Chinese subjects after a single oral administration, estimate the corresponding pharmacokinetic parameters, and conduct a pharmacokinetic comparison study with nebivolol hydrochloride tablets (NEBILET™) and amlodipine besylate tablets (Norvasc®) to determine that there are no pharmacokinetic interactions between the active ingredients in this product. Secondary Objective: To observe the safety of the test formulation (T) and control formulations (R1) nebivolol hydrochloride tablets and (R2) amlodipine besylate tablets in healthy Chinese subjects.

Comparative study on the pharmacokinetics of BCM863 tablets and other single drugs

Main purpose To study the pharmacokinetics of a single oral dose of the test preparation of sildenafil citrate orodispersible film (specification: 50 mg) and the reference preparation of sildenafil citrate orodispersible film (trade name: Viagra®, specification: 50 mg) in healthy male subjects in China under fasting and fed conditions, and to evaluate the bioequivalence of the two preparations when taken orally under fasting and fed conditions. Secondary purpose 1. To observe the safety of the test preparation of sildenafil citrate orodispersible film and the reference preparation in healthy male subjects. 2. To evaluate the taste (palatability), oral dissolution time, mucosal adhesion and irritation of the test preparation of sildenafil citrate orodispersible film and the reference preparation.